eF-site ID 1b6s-ABCD PDB Code 1b6s Chain A, B, C, D click to enlarge Title STRUCTURE OF N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE SYNTHETASE Classification LYASE Compound PROTEIN (N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE SYNTHETASE) Source ORGANISM_SCIENTIFIC: Escherichia coli; Sequence A:  MKQVCVLGNGQLGRMLRQAGEPLGIAVWPVGLDAEPAAVP FQQSVITAEIERWPETALTRELARHPAFVNRDVFPIIADR LTQKQLFDKLHLPTAPWQLLAERSEWPAVFDRLGELAIVK RRTGGGQWRLRANETEQLPAECYGECIVEQGINFSGEVSL VGARGFDGSTVFYPLTHNLHQDGILRTSVAFPQANAQQQA RAEEMLSAIMQELGYVGVMAMECFVTPQGLLINELAPRVH NSGHWTQNGASISQFELHLRAITDLPLPQPVVNNPSVMIN LIGSDVNYDWLKLPLVHLHWYDKEVRPGRKVGHLNLTDSD TSRLTATLEALIPLLPPEYASGVIWAQSKFG B:  MKQVCVLGNGQLGRMLRQAGEPLGIAVWPVGLDAEPAAVP FQQSVITAEIERWPETALTRELARHPAFVNRDVFPIIADR LTQKQLFDKLHLPTAPWQLLAERSEWPAVFDRLGELAIVK RRTGGYDGRGQWRLRANETEQLPAECYGECIVEQGINFSG EVSLVGARGFDGSTVFYPLTHNLHQDGILRTSVAFPQANA QQQARAEEMLSAIMQELGYVGVMAMECFVTPQGLLINELA PRVHNSGHWTQNGASISQFELHLRAITDLPLPQPVVNNPS VMINLIGSDVNYDWLKLPLVHLHWYDKEVRPGRKVGHLNL TDSDTSRLTATLEALIPLLPPEYASGVIWAQSKFG C:  MKQVCVLGNGQLGRMLRQAGEPLGIAVWPVGLDAEPAAVP FQQSVITAEIERWPETALTRELARHPAFVNRDVFPIIADR LTQKQLFDKLHLPTAPWQLLAERSEWPAVFDRLGELAIVK RRTGGQWRLRANETEQLPAECYGECIVEQGINFSGEVSLV GARGFDGSTVFYPLTHNLHQDGILRTSVAFPQANAQQQAR AEEMLSAIMQELGYVGVMAMECFVTPQGLLINELAPRVHN SGHWTQNGASISQFELHLRAITDLPLPQPVVNNPSVMINL IGSDVNYDWLKLPLVHLHWYDKEVRPGRKVGHLNLTDSDT SRLTATLEALIPLLPPEYASGVIWAQSKFG D:  MKQVCVLGNGQLGRMLRQAGEPLGIAVWPVGLDAEPAAVP FQQSVITAEIERWPETALTRELARHPAFVNRDVFPIIADR LTQKQLFDKLHLPTAPWQLLAERSEWPAVFDRLGELAIVK RRTGGQWRLRANETEQLPAECYGECIVEQGINFSGEVSLV GARGFDGSTVFYPLTHNLHQDGILRTSVAFPQANAQQQAR AEEMLSAIMQELGYVGVMAMECFVTPQGLLINELAPRVHN SGHWTQNGASISQFELHLRAITDLPLPQPVVNNPSVMINL IGSDVNYDWLKLPLVHLHWYDKEVRPGRKVGHLNLTDSDT SRLTATLEALIPLLPPEYASGVIWAQSKFG Description Functional site 1) chain A residue 184 type sequence H description BINDING SITE FOR RESIDUE MG A 1101 source : AC1 2) chain A residue 226 type sequence E description BINDING SITE FOR RESIDUE MG A 1101 source : AC1 3) chain A residue 238 type sequence E description BINDING SITE FOR RESIDUE MG A 1101 source : AC1 4) chain B residue 226 type sequence E description BINDING SITE FOR RESIDUE MG B 1201 source : AC2 5) chain B residue 238 type sequence E description BINDING SITE FOR RESIDUE MG B 1201 source : AC2 6) chain C residue 226 type sequence E description BINDING SITE FOR RESIDUE MG C 1301 source : AC3 7) chain C residue 238 type sequence E description BINDING SITE FOR RESIDUE MG C 1301 source : AC3 8) chain D residue 226 type sequence E description BINDING SITE FOR RESIDUE MG D 1401 source : AC4 9) chain D residue 238 type sequence E description BINDING SITE FOR RESIDUE MG D 1401 source : AC4 10) chain A residue 80 type sequence R description BINDING SITE FOR RESIDUE ADP A 1100 source : AC5 11) chain A residue 120 type sequence K description BINDING SITE FOR RESIDUE ADP A 1100 source : AC5 12) chain A residue 131 type sequence Q description BINDING SITE FOR RESIDUE ADP A 1100 source : AC5 13) chain A residue 153 type sequence E description BINDING SITE FOR RESIDUE ADP A 1100 source : AC5 14) chain A residue 154 type sequence Q description BINDING SITE FOR RESIDUE ADP A 1100 source : AC5 15) chain A residue 156 type sequence I description BINDING SITE FOR RESIDUE ADP A 1100 source : AC5 16) chain A residue 158 type sequence F description BINDING SITE FOR RESIDUE ADP A 1100 source : AC5 17) chain A residue 161 type sequence E description BINDING SITE FOR RESIDUE ADP A 1100 source : AC5 18) chain A residue 184 type sequence H description BINDING SITE FOR RESIDUE ADP A 1100 source : AC5 19) chain A residue 228 type sequence F description BINDING SITE FOR RESIDUE ADP A 1100 source : AC5 20) chain A residue 237 type sequence N description BINDING SITE FOR RESIDUE ADP A 1100 source : AC5 21) chain A residue 238 type sequence E description BINDING SITE FOR RESIDUE ADP A 1100 source : AC5 22) chain B residue 80 type sequence R description BINDING SITE FOR RESIDUE ADP B 1200 source : AC6 23) chain B residue 118 type sequence I description BINDING SITE FOR RESIDUE ADP B 1200 source : AC6 24) chain B residue 120 type sequence K description BINDING SITE FOR RESIDUE ADP B 1200 source : AC6 25) chain B residue 125 type sequence G description BINDING SITE FOR RESIDUE ADP B 1200 source : AC6 26) chain B residue 126 type sequence Y description BINDING SITE FOR RESIDUE ADP B 1200 source : AC6 27) chain B residue 127 type sequence D description BINDING SITE FOR RESIDUE ADP B 1200 source : AC6 28) chain B residue 128 type sequence G description BINDING SITE FOR RESIDUE ADP B 1200 source : AC6 29) chain B residue 131 type sequence Q description BINDING SITE FOR RESIDUE ADP B 1200 source : AC6 30) chain B residue 133 type sequence R description BINDING SITE FOR RESIDUE ADP B 1200 source : AC6 31) chain B residue 153 type sequence E description BINDING SITE FOR RESIDUE ADP B 1200 source : AC6 32) chain B residue 154 type sequence Q description BINDING SITE FOR RESIDUE ADP B 1200 source : AC6 33) chain B residue 156 type sequence I description BINDING SITE FOR RESIDUE ADP B 1200 source : AC6 34) chain B residue 158 type sequence F description BINDING SITE FOR RESIDUE ADP B 1200 source : AC6 35) chain B residue 161 type sequence E description BINDING SITE FOR RESIDUE ADP B 1200 source : AC6 36) chain B residue 184 type sequence H description BINDING SITE FOR RESIDUE ADP B 1200 source : AC6 37) chain B residue 228 type sequence F description BINDING SITE FOR RESIDUE ADP B 1200 source : AC6 38) chain B residue 237 type sequence N description BINDING SITE FOR RESIDUE ADP B 1200 source : AC6 39) chain B residue 238 type sequence E description BINDING SITE FOR RESIDUE ADP B 1200 source : AC6 40) chain C residue 80 type sequence R description BINDING SITE FOR RESIDUE ADP C 1300 source : AC7 41) chain C residue 118 type sequence I description BINDING SITE FOR RESIDUE ADP C 1300 source : AC7 42) chain C residue 120 type sequence K description BINDING SITE FOR RESIDUE ADP C 1300 source : AC7 43) chain C residue 131 type sequence Q description BINDING SITE FOR RESIDUE ADP C 1300 source : AC7 44) chain C residue 153 type sequence E description BINDING SITE FOR RESIDUE ADP C 1300 source : AC7 45) chain C residue 154 type sequence Q description BINDING SITE FOR RESIDUE ADP C 1300 source : AC7 46) chain C residue 156 type sequence I description BINDING SITE FOR RESIDUE ADP C 1300 source : AC7 47) chain C residue 158 type sequence F description BINDING SITE FOR RESIDUE ADP C 1300 source : AC7 48) chain C residue 161 type sequence E description BINDING SITE FOR RESIDUE ADP C 1300 source : AC7 49) chain C residue 184 type sequence H description BINDING SITE FOR RESIDUE ADP C 1300 source : AC7 50) chain C residue 228 type sequence F description BINDING SITE FOR RESIDUE ADP C 1300 source : AC7 51) chain C residue 237 type sequence N description BINDING SITE FOR RESIDUE ADP C 1300 source : AC7 52) chain C residue 238 type sequence E description BINDING SITE FOR RESIDUE ADP C 1300 source : AC7 53) chain D residue 80 type sequence R description BINDING SITE FOR RESIDUE ADP D 1400 source : AC8 54) chain D residue 120 type sequence K description BINDING SITE FOR RESIDUE ADP D 1400 source : AC8 55) chain D residue 131 type sequence Q description BINDING SITE FOR RESIDUE ADP D 1400 source : AC8 56) chain D residue 133 type sequence R description BINDING SITE FOR RESIDUE ADP D 1400 source : AC8 57) chain D residue 153 type sequence E description BINDING SITE FOR RESIDUE ADP D 1400 source : AC8 58) chain D residue 154 type sequence Q description BINDING SITE FOR RESIDUE ADP D 1400 source : AC8 59) chain D residue 156 type sequence I description BINDING SITE FOR RESIDUE ADP D 1400 source : AC8 60) chain D residue 158 type sequence F description BINDING SITE FOR RESIDUE ADP D 1400 source : AC8 61) chain D residue 161 type sequence E description BINDING SITE FOR RESIDUE ADP D 1400 source : AC8 62) chain D residue 184 type sequence H description BINDING SITE FOR RESIDUE ADP D 1400 source : AC8 63) chain D residue 228 type sequence F description BINDING SITE FOR RESIDUE ADP D 1400 source : AC8 64) chain D residue 237 type sequence N description BINDING SITE FOR RESIDUE ADP D 1400 source : AC8 65) chain D residue 238 type sequence E description BINDING SITE FOR RESIDUE ADP D 1400 source : AC8 66) chain A residue 80 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 67) chain A residue 120 type BINDING sequence K description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 68) chain A residue 125 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 69) chain A residue 153 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 70) chain A residue 161 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 71) chain A residue 184 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 72) chain A residue 237 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 73) chain B residue 80 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 74) chain B residue 120 type BINDING sequence K description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 75) chain B residue 125 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 76) chain B residue 153 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 77) chain B residue 161 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 78) chain B residue 184 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 79) chain B residue 237 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 80) chain C residue 80 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 81) chain C residue 120 type BINDING sequence K description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 82) chain C residue 153 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 83) chain C residue 161 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 84) chain C residue 184 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 85) chain C residue 237 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 86) chain D residue 80 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 87) chain D residue 120 type BINDING sequence K description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 88) chain D residue 153 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 89) chain D residue 161 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 90) chain D residue 184 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1 91) chain D residue 237 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:10569930, ECO:0000269|PubMed:19053251 source Swiss-Prot : SWS_FT_FI1

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