eF-site ID 1b6p-AB PDB Code 1b6p Chain A, B click to enlarge Title HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 7 Classification HYDROLASE/HYDROLASE INHIBITOR Compound RETROPEPSIN Source ORGANISM_SCIENTIFIC: Human immunodeficiency virus 1; Sequence A:  PQITLWKRPLVTIRIGGQLKEALLDTGADDTVIEEMNLPG KWKPKMIGGIGGFIKVRQYDQIPVEIXGHKAIGTVLVGPT PVNIIGRNLLTQIGXTLNF B:  PQITLWKRPLVTIRIGGQLKEALLDTGADDTVIEEMNLPG KWKPKMIGGIGGFIKVRQYDQIPVEIXGHKAIGTVLVGPT PVNIIGRNLLTQIGXTLNF Description Functional site 1) chain A residue 68 type sequence G description BINDING SITE FOR RESIDUE SO4 B 501 source : AC1 2) chain A residue 70 type sequence K description BINDING SITE FOR RESIDUE SO4 B 501 source : AC1 3) chain B residue 101 type sequence P description BINDING SITE FOR RESIDUE SO4 B 501 source : AC1 4) chain B residue 155 type sequence K description BINDING SITE FOR RESIDUE SO4 B 501 source : AC1 5) chain A residue 1 type sequence P description BINDING SITE FOR RESIDUE SO4 A 502 source : AC2 6) chain A residue 57 type sequence R description BINDING SITE FOR RESIDUE SO4 A 502 source : AC2 7) chain A residue 69 type sequence H description BINDING SITE FOR RESIDUE SO4 A 502 source : AC2 8) chain A residue 14 type sequence R description BINDING SITE FOR RESIDUE SO4 A 503 source : AC3 9) chain A residue 17 type sequence G description BINDING SITE FOR RESIDUE SO4 A 503 source : AC3 10) chain B residue 116 type sequence G description BINDING SITE FOR RESIDUE SO4 A 503 source : AC3 11) chain B residue 117 type sequence G description BINDING SITE FOR RESIDUE SO4 A 503 source : AC3 12) chain A residue 8 type sequence R description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 13) chain A residue 25 type sequence D description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 14) chain A residue 27 type sequence G description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 15) chain A residue 29 type sequence D description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 16) chain A residue 32 type sequence V description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 17) chain A residue 48 type sequence G description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 18) chain A residue 49 type sequence G description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 19) chain A residue 50 type sequence I description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 20) chain A residue 81 type sequence P description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 21) chain A residue 82 type sequence V description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 22) chain A residue 84 type sequence I description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 23) chain B residue 108 type sequence R description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 24) chain B residue 125 type sequence D description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 25) chain B residue 127 type sequence G description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 26) chain B residue 129 type sequence D description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 27) chain B residue 130 type sequence D description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 28) chain B residue 132 type sequence V description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 29) chain B residue 147 type sequence I description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 30) chain B residue 148 type sequence G description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 31) chain B residue 149 type sequence G description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 32) chain B residue 150 type sequence I description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 33) chain B residue 181 type sequence P description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 34) chain B residue 184 type sequence I description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 35) chain A residue 78 type SITE sequence G description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 36) chain B residue 178 type SITE sequence G description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 37) chain A residue 78 type MOD_RES sequence G description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 38) chain B residue 178 type MOD_RES sequence G description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 39) chain A residue 22-33 type prosite sequence ALLDTGADDTVI description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI source prosite : PS00141

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