eF-site ID 1b6p-A PDB Code 1b6p Chain A click to enlarge Title HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 7 Classification HYDROLASE/HYDROLASE INHIBITOR Compound RETROPEPSIN Source ORGANISM_SCIENTIFIC: Human immunodeficiency virus 1; Sequence A:  PQITLWKRPLVTIRIGGQLKEALLDTGADDTVIEEMNLPG KWKPKMIGGIGGFIKVRQYDQIPVEIXGHKAIGTVLVGPT PVNIIGRNLLTQIGXTLNF Description Functional site 1) chain A residue 68 type sequence G description BINDING SITE FOR RESIDUE SO4 B 501 source : AC1 2) chain A residue 70 type sequence K description BINDING SITE FOR RESIDUE SO4 B 501 source : AC1 3) chain A residue 1 type sequence P description BINDING SITE FOR RESIDUE SO4 A 502 source : AC2 4) chain A residue 57 type sequence R description BINDING SITE FOR RESIDUE SO4 A 502 source : AC2 5) chain A residue 69 type sequence H description BINDING SITE FOR RESIDUE SO4 A 502 source : AC2 6) chain A residue 14 type sequence R description BINDING SITE FOR RESIDUE SO4 A 503 source : AC3 7) chain A residue 17 type sequence G description BINDING SITE FOR RESIDUE SO4 A 503 source : AC3 8) chain A residue 8 type sequence R description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 9) chain A residue 25 type sequence D description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 10) chain A residue 27 type sequence G description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 11) chain A residue 29 type sequence D description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 12) chain A residue 32 type sequence V description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 13) chain A residue 48 type sequence G description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 14) chain A residue 49 type sequence G description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 15) chain A residue 50 type sequence I description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 16) chain A residue 81 type sequence P description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 17) chain A residue 82 type sequence V description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 18) chain A residue 84 type sequence I description BINDING SITE FOR RESIDUE PI7 A 201 source : AC4 19) chain A residue 78 type SITE sequence G description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 20) chain A residue 78 type MOD_RES sequence G description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 21) chain A residue 22-33 type prosite sequence ALLDTGADDTVI description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI source prosite : PS00141

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