eF-site ID 1azy-AB PDB Code 1azy Chain A, B click to enlarge Title STRUCTURAL AND THEORETICAL STUDIES SUGGEST DOMAIN MOVEMENT PRODUCES AN ACTIVE CONFORMATION OF THYMIDINE PHOSPHORYLASE Classification GLYCOSYLTRANSFERASE Compound THYMIDINE PHOSPHORYLASE Source ORGANISM_SCIENTIFIC: Escherichia coli; Sequence A:  LFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIA ALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLHLNGP IVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHT GGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSL APADKRFYATRDITATVDSIPLITASILAKKLAEGLDALV MDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLT DMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALC VEMLISGKLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQ KGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALG MAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLA VIHAKDENNWQEAAKAVKAAIKLADKAPESTPTVYRRISE B:  LFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIA ALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLHLNGP IVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHT GGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSL APADKRFYATRDITATVDSIPLITASILAKKLAEGLDALV MDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLT DMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALC VEMLISGKLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQ KGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALG MAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLA VIHAKDENNWQEAAKAVKAAIKLADKAPESTPTVYRRISE Description Functional site 1) chain A residue 84 type sequence K description PHOSPHATE BINDING SITE. source : P4A 2) chain A residue 85 type sequence H description PHOSPHATE BINDING SITE. source : P4A 3) chain A residue 86 type sequence S description PHOSPHATE BINDING SITE. source : P4A 4) chain A residue 95 type sequence S description PHOSPHATE BINDING SITE. source : P4A 5) chain A residue 113 type sequence S description PHOSPHATE BINDING SITE. source : P4A 6) chain A residue 123 type sequence T description PHOSPHATE BINDING SITE. source : P4A 7) chain A residue 171 type sequence R description THYMIDINE BINDING SITE. source : TYA 8) chain A residue 186 type sequence S description THYMIDINE BINDING SITE. source : TYA 9) chain A residue 190 type sequence K description THYMIDINE BINDING SITE. source : TYA 10) chain B residue 84 type sequence K description PHOSPHATE BINDING SITE. source : P4B 11) chain B residue 85 type sequence H description PHOSPHATE BINDING SITE. source : P4B 12) chain B residue 86 type sequence S description PHOSPHATE BINDING SITE. source : P4B 13) chain B residue 95 type sequence S description PHOSPHATE BINDING SITE. source : P4B 14) chain B residue 113 type sequence S description PHOSPHATE BINDING SITE. source : P4B 15) chain B residue 123 type sequence T description PHOSPHATE BINDING SITE. source : P4B 16) chain B residue 171 type sequence R description THYMIDINE BINDING SITE. source : TYB 17) chain B residue 186 type sequence S description THYMIDINE BINDING SITE. source : TYB 18) chain B residue 190 type sequence K description THYMIDINE BINDING SITE. source : TYB 19) chain A residue 83 type catalytic sequence D description 413 source MCSA : MCSA1 20) chain A residue 84 type catalytic sequence K description 413 source MCSA : MCSA1 21) chain A residue 85 type catalytic sequence H description 413 source MCSA : MCSA1 22) chain A residue 86 type catalytic sequence S description 413 source MCSA : MCSA1 23) chain A residue 123 type catalytic sequence T description 413 source MCSA : MCSA1 24) chain A residue 171 type catalytic sequence R description 413 source MCSA : MCSA1 25) chain A residue 186 type catalytic sequence S description 413 source MCSA : MCSA1 26) chain A residue 190 type catalytic sequence K description 413 source MCSA : MCSA1 27) chain A residue 191 type catalytic sequence K description 413 source MCSA : MCSA1 28) chain B residue 83 type catalytic sequence D description 413 source MCSA : MCSA2 29) chain B residue 84 type catalytic sequence K description 413 source MCSA : MCSA2 30) chain B residue 85 type catalytic sequence H description 413 source MCSA : MCSA2 31) chain B residue 86 type catalytic sequence S description 413 source MCSA : MCSA2 32) chain B residue 123 type catalytic sequence T description 413 source MCSA : MCSA2 33) chain B residue 171 type catalytic sequence R description 413 source MCSA : MCSA2 34) chain B residue 186 type catalytic sequence S description 413 source MCSA : MCSA2 35) chain B residue 190 type catalytic sequence K description 413 source MCSA : MCSA2 36) chain B residue 191 type catalytic sequence K description 413 source MCSA : MCSA2 37) chain A residue 113-128 type prosite sequence SGRGLGHTGGTLDKLE description THYMID_PHOSPHORYLASE Thymidine and pyrimidine-nucleoside phosphorylases signature. SGRGLghTGGTlDkLE source prosite : PS00647

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