eF-site ID 1ay6-H
PDB Code 1ay6
Chain H

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Title THROMBIN INHIBITOR FROM THEONALLA, CYCLOTHEANAMIDE-BASED MACROCYCLIC TRIPEPTIDE MOTIF
Classification HYDROLASE/HYDROLASE INHIBITOR
Compound THROMBIN LIGHT CHAIN
Source ORGANISM_COMMON: human; ORGANISM_SCIENTIFIC: Homo sapiens;
Sequence H:  IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLT
AAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISM
LEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCL
PDRETAASLLQAGYKGRVTGWGNLKETGQPSVLQVVNLPI
VERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLK
KWIQKVIDQFGE
Description


Functional site

1) chain H
residue 34
type
sequence F
description BINDING SITE FOR CHAIN I OF HIRUGEN
source : AC1

2) chain H
residue 36
type
sequence K
description BINDING SITE FOR CHAIN I OF HIRUGEN
source : AC1

3) chain H
residue 38
type
sequence Q
description BINDING SITE FOR CHAIN I OF HIRUGEN
source : AC1

4) chain H
residue 67
type
sequence R
description BINDING SITE FOR CHAIN I OF HIRUGEN
source : AC1

5) chain H
residue 73
type
sequence R
description BINDING SITE FOR CHAIN I OF HIRUGEN
source : AC1

6) chain H
residue 74
type
sequence T
description BINDING SITE FOR CHAIN I OF HIRUGEN
source : AC1

7) chain H
residue 75
type
sequence R
description BINDING SITE FOR CHAIN I OF HIRUGEN
source : AC1

8) chain H
residue 76
type
sequence Y
description BINDING SITE FOR CHAIN I OF HIRUGEN
source : AC1

9) chain H
residue 80
type
sequence E
description BINDING SITE FOR CHAIN I OF HIRUGEN
source : AC1

10) chain H
residue 81
type
sequence K
description BINDING SITE FOR CHAIN I OF HIRUGEN
source : AC1

11) chain H
residue 82
type
sequence I
description BINDING SITE FOR CHAIN I OF HIRUGEN
source : AC1

12) chain H
residue 57
type
sequence H
description BINDING SITE FOR RESIDUE 1ZV H 5
source : AC2

13) chain H
residue 98
type
sequence N
description BINDING SITE FOR RESIDUE 1ZV H 5
source : AC2

14) chain H
residue 174
type
sequence I
description BINDING SITE FOR RESIDUE 1ZV H 5
source : AC2

15) chain H
residue 189
type
sequence D
description BINDING SITE FOR RESIDUE 1ZV H 5
source : AC2

16) chain H
residue 190
type
sequence A
description BINDING SITE FOR RESIDUE 1ZV H 5
source : AC2

17) chain H
residue 192
type
sequence E
description BINDING SITE FOR RESIDUE 1ZV H 5
source : AC2

18) chain H
residue 193
type
sequence G
description BINDING SITE FOR RESIDUE 1ZV H 5
source : AC2

19) chain H
residue 195
type
sequence S
description BINDING SITE FOR RESIDUE 1ZV H 5
source : AC2

20) chain H
residue 214
type
sequence S
description BINDING SITE FOR RESIDUE 1ZV H 5
source : AC2

21) chain H
residue 215
type
sequence W
description BINDING SITE FOR RESIDUE 1ZV H 5
source : AC2

22) chain H
residue 216
type
sequence G
description BINDING SITE FOR RESIDUE 1ZV H 5
source : AC2

23) chain H
residue 219
type
sequence G
description BINDING SITE FOR RESIDUE 1ZV H 5
source : AC2

24) chain H
residue 226
type
sequence G
description BINDING SITE FOR RESIDUE 1ZV H 5
source : AC2

25) chain H
residue 57
type
sequence H
description ACTIVE SITE
source : CAT

26) chain H
residue 102
type
sequence D
description ACTIVE SITE
source : CAT

27) chain H
residue 195
type
sequence S
description ACTIVE SITE
source : CAT

28) chain H
residue 102
type MOD_RES
sequence D
description Sulfotyrosine => ECO:0000269|PubMed:17685615, ECO:0000269|PubMed:8251938
source Swiss-Prot : SWS_FT_FI1

29) chain H
residue 195
type MOD_RES
sequence S
description Sulfotyrosine => ECO:0000269|PubMed:17685615, ECO:0000269|PubMed:8251938
source Swiss-Prot : SWS_FT_FI1

30) chain H
residue 60
type CARBOHYD
sequence L
description N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:873923
source Swiss-Prot : SWS_FT_FI2

31) chain H
residue 53-58
type prosite
sequence LTAAHC
description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC
source prosite : PS00134

32) chain H
residue 189-200
type prosite
sequence DACEGDSGGPFV
description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV
source prosite : PS00135


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