eF-site ID 1axi-AB PDB Code 1axi Chain A, B click to enlarge Title STRUCTURAL PLASTICITY AT THE HGH:HGHBP INTERFACE Classification COMPLEX (HORMONE/RECEPTOR) Compound GROWTH HORMONE Source Homo sapiens (Human) (GHR_HUMAN) Sequence A:  TIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKY SFLQNPSLCFSESIPTPSNREETQQKSNLELLRISLLLIQ SWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEERIQTL MGRLTGQIFKQTYSKFDTALLKNYGLLYCFRRDMTYVATY LRIVQCRSVEGSCGF B:  EPKFTKCRSPERETFSCHWTDEGPIQLFYTRRNEWKECPD YVSAGENSCYFNSSFTSIAIPYCIKLTSNGGTVDEKCFSV DEIVQPDPPIALNWTLLNVSLTGIHADIQVRWEAPRNADI QKGWMVLEYELQYKEVNETKWKMMDPILTTSVPVYSLKVD KEYEVRVRSKQRNSGNYGEFSEVLYVTLPQM Description Functional site 1) chain B residue 148 type sequence G description BINDING SITE FOR RESIDUE SO4 B 237 source : AC1 2) chain B residue 149 type sequence I description BINDING SITE FOR RESIDUE SO4 B 237 source : AC1 3) chain B residue 150 type sequence H description BINDING SITE FOR RESIDUE SO4 B 237 source : AC1 4) chain B residue 97 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 5) chain B residue 138 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 6) chain B residue 143 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 7) chain B residue 182 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 8) chain A residue 106 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:14997482 source Swiss-Prot : SWS_FT_FI2 9) chain A residue 137 type MOD_RES sequence Q description Deamidated glutamine; by deterioration => ECO:0000269|PubMed:7028740 source Swiss-Prot : SWS_FT_FI3 10) chain A residue 53-86 type prosite sequence CFSESIPTPSNREETQQKSNLELLRISLLLIQSW description SOMATOTROPIN_1 Somatotropin, prolactin and related hormones signature 1. CfSesIpTPsnreeTqqksnleLlrisllLiqSW source prosite : PS00266 11) chain B residue 153-231 type prosite sequence IQVRWEAPRNADIQKGWMVLEYELQYKEVNETKWKMMDPI LTTSVPVYSLKVDKEYEVRVRSKQRNSGNYGEFSEVLYV description HEMATOPO_REC_L_F1 Long hematopoietin receptor, single chain family signature. IqVrWeaprnadiqkgwmvleYELqykevnetkwkmmdpilttsvpvys..LkvdkeyevrvRsKqrnsgn...YgeFsevlyV source prosite : PS01352

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