eF-site ID 1axa-AB PDB Code 1axa Chain A, B click to enlarge Title ACTIVE-SITE MOBILITY IN HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE AS DEMONSTRATED BY CRYSTAL STRUCTURE OF A28S MUTANT Classification ASPARTYL PROTEASE Compound HIV-1 PROTEASE Source (POL_HV1B1) Sequence A:  PQITLWQRPLVTIKIGGQLKEALLDTGSDDTVLEEMSLPG RWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPT PVNIIGRNLLTQIGCTLNF B:  PQITLWQRPLVTIKIGGQLKEALLDTGSDDTVLEEMSLPG RWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPT PVNIIGRNLLTQIGCTLNF Description Functional site 1) chain A residue 8 type sequence R description BINDING SITE FOR RESIDUE U0E A 100 source : AC1 2) chain A residue 25 type sequence D description BINDING SITE FOR RESIDUE U0E A 100 source : AC1 3) chain A residue 27 type sequence G description BINDING SITE FOR RESIDUE U0E A 100 source : AC1 4) chain A residue 28 type sequence S description BINDING SITE FOR RESIDUE U0E A 100 source : AC1 5) chain A residue 49 type sequence G description BINDING SITE FOR RESIDUE U0E A 100 source : AC1 6) chain A residue 50 type sequence I description BINDING SITE FOR RESIDUE U0E A 100 source : AC1 7) chain A residue 84 type sequence I description BINDING SITE FOR RESIDUE U0E A 100 source : AC1 8) chain B residue 8 type sequence R description BINDING SITE FOR RESIDUE U0E A 100 source : AC1 9) chain B residue 25 type sequence D description BINDING SITE FOR RESIDUE U0E A 100 source : AC1 10) chain B residue 27 type sequence G description BINDING SITE FOR RESIDUE U0E A 100 source : AC1 11) chain B residue 28 type sequence S description BINDING SITE FOR RESIDUE U0E A 100 source : AC1 12) chain B residue 29 type sequence D description BINDING SITE FOR RESIDUE U0E A 100 source : AC1 13) chain B residue 30 type sequence D description BINDING SITE FOR RESIDUE U0E A 100 source : AC1 14) chain B residue 47 type sequence I description BINDING SITE FOR RESIDUE U0E A 100 source : AC1 15) chain B residue 48 type sequence G description BINDING SITE FOR RESIDUE U0E A 100 source : AC1 16) chain B residue 49 type sequence G description BINDING SITE FOR RESIDUE U0E A 100 source : AC1 17) chain B residue 50 type sequence I description BINDING SITE FOR RESIDUE U0E A 100 source : AC1 18) chain B residue 81 type sequence P description BINDING SITE FOR RESIDUE U0E A 100 source : AC1 19) chain B residue 82 type sequence V description BINDING SITE FOR RESIDUE U0E A 100 source : AC1 20) chain A residue 25 type sequence D description BINDING SITE FOR RESIDUE U0E A 101 source : AC2 21) chain A residue 27 type sequence G description BINDING SITE FOR RESIDUE U0E A 101 source : AC2 22) chain A residue 28 type sequence S description BINDING SITE FOR RESIDUE U0E A 101 source : AC2 23) chain A residue 29 type sequence D description BINDING SITE FOR RESIDUE U0E A 101 source : AC2 24) chain A residue 30 type sequence D description BINDING SITE FOR RESIDUE U0E A 101 source : AC2 25) chain A residue 47 type sequence I description BINDING SITE FOR RESIDUE U0E A 101 source : AC2 26) chain A residue 48 type sequence G description BINDING SITE FOR RESIDUE U0E A 101 source : AC2 27) chain A residue 49 type sequence G description BINDING SITE FOR RESIDUE U0E A 101 source : AC2 28) chain A residue 50 type sequence I description BINDING SITE FOR RESIDUE U0E A 101 source : AC2 29) chain A residue 81 type sequence P description BINDING SITE FOR RESIDUE U0E A 101 source : AC2 30) chain A residue 82 type sequence V description BINDING SITE FOR RESIDUE U0E A 101 source : AC2 31) chain B residue 25 type sequence D description BINDING SITE FOR RESIDUE U0E A 101 source : AC2 32) chain B residue 27 type sequence G description BINDING SITE FOR RESIDUE U0E A 101 source : AC2 33) chain B residue 28 type sequence S description BINDING SITE FOR RESIDUE U0E A 101 source : AC2 34) chain B residue 49 type sequence G description BINDING SITE FOR RESIDUE U0E A 101 source : AC2 35) chain B residue 50 type sequence I description BINDING SITE FOR RESIDUE U0E A 101 source : AC2 36) chain B residue 81 type sequence P description BINDING SITE FOR RESIDUE U0E A 101 source : AC2 37) chain A residue 64 type SITE sequence I description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 38) chain B residue 64 type SITE sequence I description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 39) chain A residue 64 type MOD_RES sequence I description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 40) chain B residue 64 type MOD_RES sequence I description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 41) chain A residue 22-33 type prosite sequence ALLDTGSDDTVL description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGSDDTVL source prosite : PS00141

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