eF-site ID 1axa-A PDB Code 1axa Chain A click to enlarge Title ACTIVE-SITE MOBILITY IN HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE AS DEMONSTRATED BY CRYSTAL STRUCTURE OF A28S MUTANT Classification ASPARTYL PROTEASE Compound HIV-1 PROTEASE Source (POL_HV1B1) Sequence A:  PQITLWQRPLVTIKIGGQLKEALLDTGSDDTVLEEMSLPG RWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPT PVNIIGRNLLTQIGCTLNF Description Functional site 1) chain A residue 8 type sequence R description BINDING SITE FOR RESIDUE U0E A 100 source : AC1 2) chain A residue 25 type sequence D description BINDING SITE FOR RESIDUE U0E A 100 source : AC1 3) chain A residue 27 type sequence G description BINDING SITE FOR RESIDUE U0E A 100 source : AC1 4) chain A residue 28 type sequence S description BINDING SITE FOR RESIDUE U0E A 100 source : AC1 5) chain A residue 49 type sequence G description BINDING SITE FOR RESIDUE U0E A 100 source : AC1 6) chain A residue 50 type sequence I description BINDING SITE FOR RESIDUE U0E A 100 source : AC1 7) chain A residue 84 type sequence I description BINDING SITE FOR RESIDUE U0E A 100 source : AC1 8) chain A residue 25 type sequence D description BINDING SITE FOR RESIDUE U0E A 101 source : AC2 9) chain A residue 27 type sequence G description BINDING SITE FOR RESIDUE U0E A 101 source : AC2 10) chain A residue 28 type sequence S description BINDING SITE FOR RESIDUE U0E A 101 source : AC2 11) chain A residue 29 type sequence D description BINDING SITE FOR RESIDUE U0E A 101 source : AC2 12) chain A residue 30 type sequence D description BINDING SITE FOR RESIDUE U0E A 101 source : AC2 13) chain A residue 47 type sequence I description BINDING SITE FOR RESIDUE U0E A 101 source : AC2 14) chain A residue 48 type sequence G description BINDING SITE FOR RESIDUE U0E A 101 source : AC2 15) chain A residue 49 type sequence G description BINDING SITE FOR RESIDUE U0E A 101 source : AC2 16) chain A residue 50 type sequence I description BINDING SITE FOR RESIDUE U0E A 101 source : AC2 17) chain A residue 81 type sequence P description BINDING SITE FOR RESIDUE U0E A 101 source : AC2 18) chain A residue 82 type sequence V description BINDING SITE FOR RESIDUE U0E A 101 source : AC2 19) chain A residue 64 type SITE sequence I description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 20) chain A residue 64 type MOD_RES sequence I description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 21) chain A residue 22-33 type prosite sequence ALLDTGSDDTVL description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGSDDTVL source prosite : PS00141

Display surface Download Links