eF-site ID 1avr-A PDB Code 1avr Chain A click to enlarge Title CRYSTAL AND MOLECULAR STRUCTURE OF HUMAN ANNEXIN V AFTER REFINEMENT. IMPLICATIONS FOR STRUCTURE, MEMBRANE BINDING AND ION CHANNEL FORMATION OF THE ANNEXIN FAMILY OF PROTEINS Classification CALCIUM/PHOSPHOLIPID BINDING Compound ANNEXIN V Source (ANXA5_HUMAN) Sequence A:  QVLRGTVTDFPGFDERADAETLRKAMKGLGTDEESILTLL TSRSNAQRQEISAAFKTLFGRDLLDDLKSELTGKFEKLIV ALMKPSRLYDAYELKHALKGAGTNEKVLTEIIASRTPEEL RAIKQVYEEEYGSSLEDDVVGDTSGYYQRMLVVLLQANRD PDAGIDEAQVEQDAQALFQAGELKWGTDEEKFITIFGTRS VSHLRKVFDKYMTISGFQIEETIDRETSGNLEQLLLAVVK SIRSIPAYLAETLYYAMKGAGTDDHTLIRVMVSRSEIDLF NIRKEFRKNFATSLYSMIKGDTSGDYKKALLLLCGED Description Functional site 1) chain A residue 100 type sequence L description BINDING SITE FOR RESIDUE CA A 321 source : AC1 2) chain A residue 102 type sequence G description BINDING SITE FOR RESIDUE CA A 321 source : AC1 3) chain A residue 104 type sequence G description BINDING SITE FOR RESIDUE CA A 321 source : AC1 4) chain A residue 144 type sequence D description BINDING SITE FOR RESIDUE CA A 321 source : AC1 5) chain A residue 259 type sequence M description BINDING SITE FOR RESIDUE CA A 322 source : AC2 6) chain A residue 261 type sequence G description BINDING SITE FOR RESIDUE CA A 322 source : AC2 7) chain A residue 263 type sequence G description BINDING SITE FOR RESIDUE CA A 322 source : AC2 8) chain A residue 303 type sequence D description BINDING SITE FOR RESIDUE CA A 322 source : AC2 9) chain A residue 28 type sequence M description BINDING SITE FOR RESIDUE CA A 323 source : AC3 10) chain A residue 30 type sequence G description BINDING SITE FOR RESIDUE CA A 323 source : AC3 11) chain A residue 32 type sequence G description BINDING SITE FOR RESIDUE CA A 323 source : AC3 12) chain A residue 72 type sequence E description BINDING SITE FOR RESIDUE CA A 323 source : AC3 13) chain A residue 33 type sequence T description BINDING SITE FOR RESIDUE CA A 324 source : AC4 14) chain A residue 35 type sequence E description BINDING SITE FOR RESIDUE CA A 324 source : AC4 15) chain A residue 70 type sequence K description BINDING SITE FOR RESIDUE CA A 325 source : AC5 16) chain A residue 73 type sequence L description BINDING SITE FOR RESIDUE CA A 325 source : AC5 17) chain A residue 78 type sequence E description BINDING SITE FOR RESIDUE CA A 325 source : AC5 18) chain A residue 25 type sequence R description BINDING SITE FOR RESIDUE SO4 A 550 source : AC6 19) chain A residue 30 type sequence G description BINDING SITE FOR RESIDUE SO4 A 550 source : AC6 20) chain A residue 63 type sequence R description BINDING SITE FOR RESIDUE SO4 A 550 source : AC6 21) chain A residue 285 type sequence R description BINDING SITE FOR RESIDUE SO4 A 551 source : AC7 22) chain A residue 286 type sequence K description BINDING SITE FOR RESIDUE SO4 A 551 source : AC7 23) chain A residue 32-84 type prosite sequence GTDEESILTLLTSRSNAQRQEISAAFKTLFGRDLLDDLKS ELTGKFEKLIVAL description ANNEXIN_1 Annexin repeat signature. GTdeesiltlLtsRsnaQrqEisaaFktlfgrdLlddLkseltGkfeklIvaL source prosite : PS00223 24) chain A residue 104-156 type prosite sequence GTNEKVLTEIIASRTPEELRAIKQVYEEEYGSSLEDDVVG DTSGYYQRMLVVL description ANNEXIN_1 Annexin repeat signature. GTdeesiltlLtsRsnaQrqEisaaFktlfgrdLlddLkseltGkfeklIvaL source prosite : PS00223 25) chain A residue 188-240 type prosite sequence GTDEEKFITIFGTRSVSHLRKVFDKYMTISGFQIEETIDR ETSGNLEQLLLAV description ANNEXIN_1 Annexin repeat signature. GTdeesiltlLtsRsnaQrqEisaaFktlfgrdLlddLkseltGkfeklIvaL source prosite : PS00223 26) chain A residue 263-315 type prosite sequence GTDDHTLIRVMVSRSEIDLFNIRKEFRKNFATSLYSMIKG DTSGDYKKALLLL description ANNEXIN_1 Annexin repeat signature. GTdeesiltlLtsRsnaQrqEisaaFktlfgrdLlddLkseltGkfeklIvaL source prosite : PS00223 27) chain A residue 30 type CROSSLNK sequence G description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI6 28) chain A residue 3 type MOD_RES sequence Q description N-acetylalanine => ECO:0007744|PubMed:19413330 source Swiss-Prot : SWS_FT_FI1 29) chain A residue 38 type MOD_RES sequence I description Phosphoserine => ECO:0000250|UniProtKB:P48036 source Swiss-Prot : SWS_FT_FI2 30) chain A residue 71 type MOD_RES sequence S description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI3 31) chain A residue 77 type MOD_RES sequence F description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI3 32) chain A residue 80 type MOD_RES sequence L description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI3 33) chain A residue 98 type MOD_RES sequence H description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI3 34) chain A residue 102 type MOD_RES sequence G description N6-acetyllysine => ECO:0007744|PubMed:16916647 source Swiss-Prot : SWS_FT_FI4 35) chain A residue 291 type MOD_RES sequence N description N6-succinyllysine => ECO:0000250|UniProtKB:P48036 source Swiss-Prot : SWS_FT_FI5

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