|
|
eF-site ID
|
1aui-AB |
|
PDB Code
|
1aui |
|
Chain
|
A, B |
|
click to enlarge
|
|
|
Title
|
HUMAN CALCINEURIN HETERODIMER |
|
Classification
|
HYDROLASE |
|
Compound
|
SERINE/THREONINE PHOSPHATASE 2B |
|
Source
|
Homo sapiens (Human) (CANB1_HUMAN) |
|
|
Sequence
|
A: |
TDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKE
GRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHG
QFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYL
WALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSER
VYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIR
KLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTV
RGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRK
SQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQ
FNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICS
SFEEAKGLDRINERMPPR
|
| B: |
SYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMS
LPELQQNPLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVK
GDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLK
DTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGLDIHKK
MVVDV
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
90 |
| type |
|
| sequence |
D
|
| description |
FE BINDING SITE.
|
| source |
: FEB
|
|
|
2)
|
chain |
A |
| residue |
92 |
| type |
|
| sequence |
H
|
| description |
FE BINDING SITE.
|
| source |
: FEB
|
|
|
3)
|
chain |
A |
| residue |
118 |
| type |
|
| sequence |
D
|
| description |
FE BINDING SITE.
|
| source |
: FEB
|
|
|
4)
|
chain |
A |
| residue |
118 |
| type |
|
| sequence |
D
|
| description |
ZN BINDING SITE.
|
| source |
: ZNB
|
|
|
5)
|
chain |
A |
| residue |
150 |
| type |
|
| sequence |
N
|
| description |
ZN BINDING SITE.
|
| source |
: ZNB
|
|
|
6)
|
chain |
A |
| residue |
199 |
| type |
|
| sequence |
H
|
| description |
ZN BINDING SITE.
|
| source |
: ZNB
|
|
|
7)
|
chain |
A |
| residue |
281 |
| type |
|
| sequence |
H
|
| description |
ZN BINDING SITE.
|
| source |
: ZNB
|
|
|
8)
|
chain |
B |
| residue |
30 |
| type |
|
| sequence |
D
|
| description |
CALCIUM BINDING SITE.
|
| source |
: CA1
|
|
|
9)
|
chain |
B |
| residue |
32 |
| type |
|
| sequence |
D
|
| description |
CALCIUM BINDING SITE.
|
| source |
: CA1
|
|
|
10)
|
chain |
B |
| residue |
34 |
| type |
|
| sequence |
S
|
| description |
CALCIUM BINDING SITE.
|
| source |
: CA1
|
|
|
11)
|
chain |
B |
| residue |
36 |
| type |
|
| sequence |
S
|
| description |
CALCIUM BINDING SITE.
|
| source |
: CA1
|
|
|
12)
|
chain |
B |
| residue |
41 |
| type |
|
| sequence |
E
|
| description |
CALCIUM BINDING SITE.
|
| source |
: CA1
|
|
|
13)
|
chain |
B |
| residue |
62 |
| type |
|
| sequence |
D
|
| description |
CALCIUM BINDING SITE.
|
| source |
: CA2
|
|
|
14)
|
chain |
B |
| residue |
64 |
| type |
|
| sequence |
D
|
| description |
CALCIUM BINDING SITE.
|
| source |
: CA2
|
|
|
15)
|
chain |
B |
| residue |
66 |
| type |
|
| sequence |
N
|
| description |
CALCIUM BINDING SITE.
|
| source |
: CA2
|
|
|
16)
|
chain |
B |
| residue |
68 |
| type |
|
| sequence |
E
|
| description |
CALCIUM BINDING SITE.
|
| source |
: CA2
|
|
|
17)
|
chain |
B |
| residue |
73 |
| type |
|
| sequence |
E
|
| description |
CALCIUM BINDING SITE.
|
| source |
: CA2
|
|
|
18)
|
chain |
B |
| residue |
99 |
| type |
|
| sequence |
D
|
| description |
CALCIUM BINDING SITE.
|
| source |
: CA3
|
|
|
19)
|
chain |
B |
| residue |
101 |
| type |
|
| sequence |
D
|
| description |
CALCIUM BINDING SITE.
|
| source |
: CA3
|
|
|
20)
|
chain |
B |
| residue |
103 |
| type |
|
| sequence |
D
|
| description |
CALCIUM BINDING SITE.
|
| source |
: CA3
|
|
|
21)
|
chain |
B |
| residue |
105 |
| type |
|
| sequence |
Y
|
| description |
CALCIUM BINDING SITE.
|
| source |
: CA3
|
|
|
22)
|
chain |
B |
| residue |
110 |
| type |
|
| sequence |
E
|
| description |
CALCIUM BINDING SITE.
|
| source |
: CA3
|
|
|
23)
|
chain |
B |
| residue |
140 |
| type |
|
| sequence |
D
|
| description |
CALCIUM BINDING SITE.
|
| source |
: CA4
|
|
|
24)
|
chain |
B |
| residue |
142 |
| type |
|
| sequence |
D
|
| description |
CALCIUM BINDING SITE.
|
| source |
: CA4
|
|
|
25)
|
chain |
B |
| residue |
144 |
| type |
|
| sequence |
D
|
| description |
CALCIUM BINDING SITE.
|
| source |
: CA4
|
|
|
26)
|
chain |
B |
| residue |
146 |
| type |
|
| sequence |
R
|
| description |
CALCIUM BINDING SITE.
|
| source |
: CA4
|
|
|
27)
|
chain |
B |
| residue |
151 |
| type |
|
| sequence |
E
|
| description |
CALCIUM BINDING SITE.
|
| source |
: CA4
|
|
|
28)
|
chain |
B |
| residue |
30 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE CA B 500
|
| source |
: AC1
|
|
|
29)
|
chain |
B |
| residue |
32 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE CA B 500
|
| source |
: AC1
|
|
|
30)
|
chain |
B |
| residue |
34 |
| type |
|
| sequence |
S
|
| description |
BINDING SITE FOR RESIDUE CA B 500
|
| source |
: AC1
|
|
|
31)
|
chain |
B |
| residue |
36 |
| type |
|
| sequence |
S
|
| description |
BINDING SITE FOR RESIDUE CA B 500
|
| source |
: AC1
|
|
|
32)
|
chain |
B |
| residue |
41 |
| type |
|
| sequence |
E
|
| description |
BINDING SITE FOR RESIDUE CA B 500
|
| source |
: AC1
|
|
|
33)
|
chain |
B |
| residue |
62 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE CA B 501
|
| source |
: AC2
|
|
|
34)
|
chain |
B |
| residue |
64 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE CA B 501
|
| source |
: AC2
|
|
|
35)
|
chain |
B |
| residue |
66 |
| type |
|
| sequence |
N
|
| description |
BINDING SITE FOR RESIDUE CA B 501
|
| source |
: AC2
|
|
|
36)
|
chain |
B |
| residue |
68 |
| type |
|
| sequence |
E
|
| description |
BINDING SITE FOR RESIDUE CA B 501
|
| source |
: AC2
|
|
|
37)
|
chain |
B |
| residue |
73 |
| type |
|
| sequence |
E
|
| description |
BINDING SITE FOR RESIDUE CA B 501
|
| source |
: AC2
|
|
|
38)
|
chain |
B |
| residue |
99 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE CA B 502
|
| source |
: AC3
|
|
|
39)
|
chain |
B |
| residue |
101 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE CA B 502
|
| source |
: AC3
|
|
|
40)
|
chain |
B |
| residue |
103 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE CA B 502
|
| source |
: AC3
|
|
|
41)
|
chain |
B |
| residue |
105 |
| type |
|
| sequence |
Y
|
| description |
BINDING SITE FOR RESIDUE CA B 502
|
| source |
: AC3
|
|
|
42)
|
chain |
B |
| residue |
110 |
| type |
|
| sequence |
E
|
| description |
BINDING SITE FOR RESIDUE CA B 502
|
| source |
: AC3
|
|
|
43)
|
chain |
B |
| residue |
140 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE CA B 503
|
| source |
: AC4
|
|
|
44)
|
chain |
B |
| residue |
142 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE CA B 503
|
| source |
: AC4
|
|
|
45)
|
chain |
B |
| residue |
144 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE CA B 503
|
| source |
: AC4
|
|
|
46)
|
chain |
B |
| residue |
146 |
| type |
|
| sequence |
R
|
| description |
BINDING SITE FOR RESIDUE CA B 503
|
| source |
: AC4
|
|
|
47)
|
chain |
B |
| residue |
151 |
| type |
|
| sequence |
E
|
| description |
BINDING SITE FOR RESIDUE CA B 503
|
| source |
: AC4
|
|
|
48)
|
chain |
A |
| residue |
118 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE ZN A 522
|
| source |
: AC5
|
|
|
49)
|
chain |
A |
| residue |
150 |
| type |
|
| sequence |
N
|
| description |
BINDING SITE FOR RESIDUE ZN A 522
|
| source |
: AC5
|
|
|
50)
|
chain |
A |
| residue |
199 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE ZN A 522
|
| source |
: AC5
|
|
|
51)
|
chain |
A |
| residue |
281 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE ZN A 522
|
| source |
: AC5
|
|
|
52)
|
chain |
A |
| residue |
90 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE FE A 523
|
| source |
: AC6
|
|
|
53)
|
chain |
A |
| residue |
92 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE FE A 523
|
| source |
: AC6
|
|
|
54)
|
chain |
A |
| residue |
118 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE FE A 523
|
| source |
: AC6
|
|
|
55)
|
chain |
A |
| residue |
469 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000250|UniProtKB:P63329
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
56)
|
chain |
A |
| residue |
90 |
| type |
catalytic |
| sequence |
D
|
| description |
406
|
| source |
MCSA : MCSA1
|
|
|
57)
|
chain |
A |
| residue |
281 |
| type |
catalytic |
| sequence |
H
|
| description |
406
|
| source |
MCSA : MCSA1
|
|
|
58)
|
chain |
A |
| residue |
92 |
| type |
catalytic |
| sequence |
H
|
| description |
406
|
| source |
MCSA : MCSA1
|
|
|
59)
|
chain |
A |
| residue |
118 |
| type |
catalytic |
| sequence |
D
|
| description |
406
|
| source |
MCSA : MCSA1
|
|
|
60)
|
chain |
A |
| residue |
121 |
| type |
catalytic |
| sequence |
D
|
| description |
406
|
| source |
MCSA : MCSA1
|
|
|
61)
|
chain |
A |
| residue |
122 |
| type |
catalytic |
| sequence |
R
|
| description |
406
|
| source |
MCSA : MCSA1
|
|
|
62)
|
chain |
A |
| residue |
150 |
| type |
catalytic |
| sequence |
N
|
| description |
406
|
| source |
MCSA : MCSA1
|
|
|
63)
|
chain |
A |
| residue |
151 |
| type |
catalytic |
| sequence |
H
|
| description |
406
|
| source |
MCSA : MCSA1
|
|
|
64)
|
chain |
A |
| residue |
199 |
| type |
catalytic |
| sequence |
H
|
| description |
406
|
| source |
MCSA : MCSA1
|
|
|
65)
|
chain |
A |
| residue |
254 |
| type |
catalytic |
| sequence |
R
|
| description |
406
|
| source |
MCSA : MCSA1
|
|
|
66)
|
chain |
B |
| residue |
30-42 |
| type |
prosite |
| sequence |
DLDNSGSLSVEEF
|
| description |
EF_HAND_1 EF-hand calcium-binding domain. DLDNSGSLSveEF
|
| source |
prosite : PS00018
|
|
|
67)
|
chain |
B |
| residue |
62-74 |
| type |
prosite |
| sequence |
DTDGNGEVDFKEF
|
| description |
EF_HAND_1 EF-hand calcium-binding domain. DLDNSGSLSveEF
|
| source |
prosite : PS00018
|
|
|
68)
|
chain |
B |
| residue |
99-111 |
| type |
prosite |
| sequence |
DMDKDGYISNGEL
|
| description |
EF_HAND_1 EF-hand calcium-binding domain. DLDNSGSLSveEF
|
| source |
prosite : PS00018
|
|
|
69)
|
chain |
B |
| residue |
140-152 |
| type |
prosite |
| sequence |
DKDGDGRISFEEF
|
| description |
EF_HAND_1 EF-hand calcium-binding domain. DLDNSGSLSveEF
|
| source |
prosite : PS00018
|
|
|
70)
|
chain |
B |
| residue |
31 |
| type |
BINDING |
| sequence |
L
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:8524402, ECO:0007744|PDB:1AUI, ECO:0007744|PDB:1M63, ECO:0007744|PDB:1MF8, ECO:0007744|PDB:2P6B, ECO:0007744|PDB:3LL8, ECO:0007744|PDB:4F0Z, ECO:0007744|PDB:4OR9, ECO:0007744|PDB:4ORA, ECO:0007744|PDB:4ORC, ECO:0007744|PDB:5SVE
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
71)
|
chain |
B |
| residue |
74 |
| type |
BINDING |
| sequence |
F
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:8524402, ECO:0007744|PDB:1AUI, ECO:0007744|PDB:1M63, ECO:0007744|PDB:1MF8, ECO:0007744|PDB:2P6B, ECO:0007744|PDB:3LL8, ECO:0007744|PDB:4F0Z, ECO:0007744|PDB:4OR9, ECO:0007744|PDB:4ORA, ECO:0007744|PDB:4ORC, ECO:0007744|PDB:5SVE
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
72)
|
chain |
B |
| residue |
141 |
| type |
BINDING |
| sequence |
K
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:8524402, ECO:0007744|PDB:1AUI, ECO:0007744|PDB:1M63, ECO:0007744|PDB:1MF8, ECO:0007744|PDB:2P6B, ECO:0007744|PDB:3LL8, ECO:0007744|PDB:4F0Z, ECO:0007744|PDB:4OR9, ECO:0007744|PDB:4ORA, ECO:0007744|PDB:4ORC, ECO:0007744|PDB:5SVE
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
73)
|
chain |
B |
| residue |
143 |
| type |
BINDING |
| sequence |
G
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:8524402, ECO:0007744|PDB:1AUI, ECO:0007744|PDB:1M63, ECO:0007744|PDB:1MF8, ECO:0007744|PDB:2P6B, ECO:0007744|PDB:3LL8, ECO:0007744|PDB:4F0Z, ECO:0007744|PDB:4OR9, ECO:0007744|PDB:4ORA, ECO:0007744|PDB:4ORC, ECO:0007744|PDB:5SVE
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
74)
|
chain |
B |
| residue |
145 |
| type |
BINDING |
| sequence |
G
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:8524402, ECO:0007744|PDB:1AUI, ECO:0007744|PDB:1M63, ECO:0007744|PDB:1MF8, ECO:0007744|PDB:2P6B, ECO:0007744|PDB:3LL8, ECO:0007744|PDB:4F0Z, ECO:0007744|PDB:4OR9, ECO:0007744|PDB:4ORA, ECO:0007744|PDB:4ORC, ECO:0007744|PDB:5SVE
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
75)
|
chain |
B |
| residue |
147 |
| type |
BINDING |
| sequence |
I
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:8524402, ECO:0007744|PDB:1AUI, ECO:0007744|PDB:1M63, ECO:0007744|PDB:1MF8, ECO:0007744|PDB:2P6B, ECO:0007744|PDB:3LL8, ECO:0007744|PDB:4F0Z, ECO:0007744|PDB:4OR9, ECO:0007744|PDB:4ORA, ECO:0007744|PDB:4ORC, ECO:0007744|PDB:5SVE
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
76)
|
chain |
B |
| residue |
152 |
| type |
BINDING |
| sequence |
F
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:8524402, ECO:0007744|PDB:1AUI, ECO:0007744|PDB:1M63, ECO:0007744|PDB:1MF8, ECO:0007744|PDB:2P6B, ECO:0007744|PDB:3LL8, ECO:0007744|PDB:4F0Z, ECO:0007744|PDB:4OR9, ECO:0007744|PDB:4ORA, ECO:0007744|PDB:4ORC, ECO:0007744|PDB:5SVE
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
77)
|
chain |
B |
| residue |
33 |
| type |
BINDING |
| sequence |
N
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:8524402, ECO:0007744|PDB:1AUI, ECO:0007744|PDB:1M63, ECO:0007744|PDB:1MF8, ECO:0007744|PDB:2P6B, ECO:0007744|PDB:3LL8, ECO:0007744|PDB:4F0Z, ECO:0007744|PDB:4OR9, ECO:0007744|PDB:4ORA, ECO:0007744|PDB:4ORC, ECO:0007744|PDB:5SVE
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
78)
|
chain |
B |
| residue |
35 |
| type |
BINDING |
| sequence |
G
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:8524402, ECO:0007744|PDB:1AUI, ECO:0007744|PDB:1M63, ECO:0007744|PDB:1MF8, ECO:0007744|PDB:2P6B, ECO:0007744|PDB:3LL8, ECO:0007744|PDB:4F0Z, ECO:0007744|PDB:4OR9, ECO:0007744|PDB:4ORA, ECO:0007744|PDB:4ORC, ECO:0007744|PDB:5SVE
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
79)
|
chain |
B |
| residue |
37 |
| type |
BINDING |
| sequence |
L
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:8524402, ECO:0007744|PDB:1AUI, ECO:0007744|PDB:1M63, ECO:0007744|PDB:1MF8, ECO:0007744|PDB:2P6B, ECO:0007744|PDB:3LL8, ECO:0007744|PDB:4F0Z, ECO:0007744|PDB:4OR9, ECO:0007744|PDB:4ORA, ECO:0007744|PDB:4ORC, ECO:0007744|PDB:5SVE
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
80)
|
chain |
B |
| residue |
42 |
| type |
BINDING |
| sequence |
F
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:8524402, ECO:0007744|PDB:1AUI, ECO:0007744|PDB:1M63, ECO:0007744|PDB:1MF8, ECO:0007744|PDB:2P6B, ECO:0007744|PDB:3LL8, ECO:0007744|PDB:4F0Z, ECO:0007744|PDB:4OR9, ECO:0007744|PDB:4ORA, ECO:0007744|PDB:4ORC, ECO:0007744|PDB:5SVE
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
81)
|
chain |
B |
| residue |
63 |
| type |
BINDING |
| sequence |
T
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:8524402, ECO:0007744|PDB:1AUI, ECO:0007744|PDB:1M63, ECO:0007744|PDB:1MF8, ECO:0007744|PDB:2P6B, ECO:0007744|PDB:3LL8, ECO:0007744|PDB:4F0Z, ECO:0007744|PDB:4OR9, ECO:0007744|PDB:4ORA, ECO:0007744|PDB:4ORC, ECO:0007744|PDB:5SVE
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
82)
|
chain |
B |
| residue |
65 |
| type |
BINDING |
| sequence |
G
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:8524402, ECO:0007744|PDB:1AUI, ECO:0007744|PDB:1M63, ECO:0007744|PDB:1MF8, ECO:0007744|PDB:2P6B, ECO:0007744|PDB:3LL8, ECO:0007744|PDB:4F0Z, ECO:0007744|PDB:4OR9, ECO:0007744|PDB:4ORA, ECO:0007744|PDB:4ORC, ECO:0007744|PDB:5SVE
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
83)
|
chain |
B |
| residue |
67 |
| type |
BINDING |
| sequence |
G
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:8524402, ECO:0007744|PDB:1AUI, ECO:0007744|PDB:1M63, ECO:0007744|PDB:1MF8, ECO:0007744|PDB:2P6B, ECO:0007744|PDB:3LL8, ECO:0007744|PDB:4F0Z, ECO:0007744|PDB:4OR9, ECO:0007744|PDB:4ORA, ECO:0007744|PDB:4ORC, ECO:0007744|PDB:5SVE
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
84)
|
chain |
B |
| residue |
69 |
| type |
BINDING |
| sequence |
V
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:8524402, ECO:0007744|PDB:1AUI, ECO:0007744|PDB:1M63, ECO:0007744|PDB:1MF8, ECO:0007744|PDB:2P6B, ECO:0007744|PDB:3LL8, ECO:0007744|PDB:4F0Z, ECO:0007744|PDB:4OR9, ECO:0007744|PDB:4ORA, ECO:0007744|PDB:4ORC, ECO:0007744|PDB:5SVE
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
85)
|
chain |
B |
| residue |
100 |
| type |
BINDING |
| sequence |
M
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:31375679, ECO:0000269|PubMed:8524402, ECO:0000312|PDB:6NUC, ECO:0007744|PDB:1AUI, ECO:0007744|PDB:1M63, ECO:0007744|PDB:1MF8, ECO:0007744|PDB:2P6B, ECO:0007744|PDB:3LL8, ECO:0007744|PDB:4F0Z, ECO:0007744|PDB:4OR9, ECO:0007744|PDB:4ORA, ECO:0007744|PDB:4ORC, ECO:0007744|PDB:5SVE
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
86)
|
chain |
B |
| residue |
102 |
| type |
BINDING |
| sequence |
K
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:31375679, ECO:0000269|PubMed:8524402, ECO:0000312|PDB:6NUC, ECO:0007744|PDB:1AUI, ECO:0007744|PDB:1M63, ECO:0007744|PDB:1MF8, ECO:0007744|PDB:2P6B, ECO:0007744|PDB:3LL8, ECO:0007744|PDB:4F0Z, ECO:0007744|PDB:4OR9, ECO:0007744|PDB:4ORA, ECO:0007744|PDB:4ORC, ECO:0007744|PDB:5SVE
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
87)
|
chain |
B |
| residue |
104 |
| type |
BINDING |
| sequence |
G
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:31375679, ECO:0000269|PubMed:8524402, ECO:0000312|PDB:6NUC, ECO:0007744|PDB:1AUI, ECO:0007744|PDB:1M63, ECO:0007744|PDB:1MF8, ECO:0007744|PDB:2P6B, ECO:0007744|PDB:3LL8, ECO:0007744|PDB:4F0Z, ECO:0007744|PDB:4OR9, ECO:0007744|PDB:4ORA, ECO:0007744|PDB:4ORC, ECO:0007744|PDB:5SVE
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
88)
|
chain |
B |
| residue |
106 |
| type |
BINDING |
| sequence |
I
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:31375679, ECO:0000269|PubMed:8524402, ECO:0000312|PDB:6NUC, ECO:0007744|PDB:1AUI, ECO:0007744|PDB:1M63, ECO:0007744|PDB:1MF8, ECO:0007744|PDB:2P6B, ECO:0007744|PDB:3LL8, ECO:0007744|PDB:4F0Z, ECO:0007744|PDB:4OR9, ECO:0007744|PDB:4ORA, ECO:0007744|PDB:4ORC, ECO:0007744|PDB:5SVE
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
89)
|
chain |
B |
| residue |
111 |
| type |
BINDING |
| sequence |
L
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:31375679, ECO:0000269|PubMed:8524402, ECO:0000312|PDB:6NUC, ECO:0007744|PDB:1AUI, ECO:0007744|PDB:1M63, ECO:0007744|PDB:1MF8, ECO:0007744|PDB:2P6B, ECO:0007744|PDB:3LL8, ECO:0007744|PDB:4F0Z, ECO:0007744|PDB:4OR9, ECO:0007744|PDB:4ORA, ECO:0007744|PDB:4ORC, ECO:0007744|PDB:5SVE
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
90)
|
chain |
A |
| residue |
281 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:31375679, ECO:0000269|PubMed:8524402, ECO:0000312|PDB:6NUC, ECO:0007744|PDB:1AUI, ECO:0007744|PDB:1M63, ECO:0007744|PDB:1MF8, ECO:0007744|PDB:2P6B, ECO:0007744|PDB:3LL8, ECO:0007744|PDB:4F0Z, ECO:0007744|PDB:4OR9, ECO:0007744|PDB:4ORA, ECO:0007744|PDB:4ORC, ECO:0007744|PDB:5SVE
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
91)
|
chain |
B |
| residue |
118 |
| type |
SITE |
| sequence |
M
|
| description |
Interaction with PxVP motif in substrates of the catalytic subunit => ECO:0000269|PubMed:23468591
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
92)
|
chain |
B |
| residue |
122 |
| type |
SITE |
| sequence |
N
|
| description |
Interaction with PxVP motif in substrates of the catalytic subunit => ECO:0000269|PubMed:23468591
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
93)
|
chain |
B |
| residue |
106 |
| type |
MOD_RES |
| sequence |
I
|
| description |
Phosphotyrosine => ECO:0000250|UniProtKB:Q63810
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
94)
|
chain |
A |
| residue |
147-152 |
| type |
prosite |
| sequence |
LRGNHE
|
| description |
SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE
|
| source |
prosite : PS00125
|
|
|
|