eF-site ID 1aqd-ABCDEFGHIJKL
PDB Code 1aqd
Chain A, B, C, D, E, F, G, H, I, J, K, L

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Title HLA-DR1 (DRA, DRB1 0101) HUMAN CLASS II HISTOCOMPATIBILITY PROTEIN (EXTRACELLULAR DOMAIN) COMPLEXED WITH ENDOGENOUS PEPTIDE
Classification COMPLEX (MHC PROTEIN/ANTIGEN)
Compound HLA-DR1 CLASS II HISTOCOMPATIBILITY PROTEIN
Source Homo sapiens (Human) (1A02_HUMAN)
Sequence A:  EEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETV
WRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPI
TNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWL
RNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYD
CRVEHWGLDEPLLKHWEFD
B:  RPRFLWQLKFECHFFNGTERVRLLERCIYNQEESVRFDSD
VGEYRAVTELGRPDAEYWNSQKDLLEQRRAAVDTYCRHNY
GVGESFTVQRRVEPKVTVYPSKTQPLQHHNLLVCSVSGFY
PGSIEVRWFRNGQEEKAGVVSTGLIQNGDWTFQTLVMLET
VPRSGEVYTCQVEHPSVTSPLTVEWRA
C:  GSDWRFLRGYHQYA
D:  EEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETV
WRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPI
TNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWL
RNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYD
CRVEHWGLDEPLLKHWE
E:  RPRFLWQLKFECHFFNGTERVRLLERCIYNQEESVRFDSD
VGEYRAVTELGRPDAEYWNSQKDLLEQRRAAVDTYCRHNY
GVGESFTVQRRVEPKVTVYPSKTQPLQHHNLLVCSVSGFY
PGSIEVRWFRNGQEEKAGVVSTGLIQNGDWTFQTLVMLET
VPRSGEVYTCQVEHPSVTSPLTVEWRA
F:  SDWRFLRGYHQYA
G:  EEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETV
WRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPI
TNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWL
RNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYD
CRVEHWGLDEPLLKHWE
H:  RPRFLWQLKFECHFFNGTERVRLLERCIYNQEESVRFDSD
VGEYRAVTELGRPDAEYWNSQKDLLEQRRAAVDTYCRHNY
GVGESFTVQRRVEPKVTVYPSKTQPLQHHNLLVCSVSGFY
PGSIEVRWFRNGQEEKAGVVSTGLIQNGDWTFQTLVMLET
VPRSGEVYTCQVEHPSVTSPLTVEWRA
I:  GSDWRFLRGYHQYA
J:  EEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETV
WRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPI
TNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWL
RNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYD
CRVEHWGLDEPLLKHWE
K:  RPRFLWQLKFECHFFNGTERVRLLERCIYNQEESVRFDSD
VGEYRAVTELGRPDAEYWNSQKDLLEQRRAAVDTYCRHNY
GVGESFTVQRRVEPKVTVYPSKTQPLQHHNLLVCSVSGFY
PGSIEVRWFRNGQEEKAGVVSTGLIQNGDWTFQTLVMLET
VPRSGEVYTCQVEHPSVTSPLTVEWRAR
L:  GSDWRFLRGYHQYA
Description


Functional site
1) chain B
residue 171-177
type prosite
sequence YTCQVEH
description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCQVEH
source prosite : PS00290
2) chain A
residue 161-167
type prosite
sequence YDCRVEH
description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCQVEH
source prosite : PS00290
3) chain C
residue 14
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:21543847
source Swiss-Prot : SWS_FT_FI1
4) chain F
residue 14
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:21543847
source Swiss-Prot : SWS_FT_FI1
5) chain I
residue 14
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:21543847
source Swiss-Prot : SWS_FT_FI1
6) chain L
residue 14
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:21543847
source Swiss-Prot : SWS_FT_FI1
7) chain A
residue 78
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400
source Swiss-Prot : SWS_FT_FI10
8) chain A
residue 118
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400
source Swiss-Prot : SWS_FT_FI10
9) chain D
residue 78
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400
source Swiss-Prot : SWS_FT_FI10
10) chain D
residue 118
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400
source Swiss-Prot : SWS_FT_FI10
11) chain G
residue 78
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400
source Swiss-Prot : SWS_FT_FI10
12) chain G
residue 118
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400
source Swiss-Prot : SWS_FT_FI10
13) chain J
residue 78
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400
source Swiss-Prot : SWS_FT_FI10
14) chain J
residue 118
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400
source Swiss-Prot : SWS_FT_FI10
15) chain B
residue 57
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI2
16) chain H
residue 61
type BINDING
sequence W
description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI2
17) chain H
residue 81
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI2
18) chain H
residue 82
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI2
19) chain K
residue 57
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI2
20) chain K
residue 61
type BINDING
sequence W
description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI2
21) chain K
residue 81
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI2
22) chain K
residue 82
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI2
23) chain B
residue 61
type BINDING
sequence W
description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI2
24) chain B
residue 81
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI2
25) chain B
residue 82
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI2
26) chain E
residue 57
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI2
27) chain E
residue 61
type BINDING
sequence W
description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI2
28) chain E
residue 81
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI2
29) chain E
residue 82
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI2
30) chain H
residue 57
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI2
31) chain B
residue 93
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI3
32) chain E
residue 93
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI3
33) chain H
residue 93
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI3
34) chain K
residue 93
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI3
35) chain G
residue 49
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI3
36) chain G
residue 52
type BINDING
sequence A
description BINDING => ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI3
37) chain J
residue 49
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI3
38) chain J
residue 52
type BINDING
sequence A
description BINDING => ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI3
39) chain B
residue 19
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19303388, ECO:0000269|PubMed:24190431
source Swiss-Prot : SWS_FT_FI4
40) chain E
residue 19
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19303388, ECO:0000269|PubMed:24190431
source Swiss-Prot : SWS_FT_FI4
41) chain H
residue 19
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19303388, ECO:0000269|PubMed:24190431
source Swiss-Prot : SWS_FT_FI4
42) chain K
residue 19
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19303388, ECO:0000269|PubMed:24190431
source Swiss-Prot : SWS_FT_FI4
43) chain A
residue 53
type SITE
sequence S
description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI5
44) chain D
residue 53
type SITE
sequence S
description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI5
45) chain G
residue 53
type SITE
sequence S
description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI5
46) chain J
residue 53
type SITE
sequence S
description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI5
47) chain A
residue 55
type SITE
sequence E
description Pathogen-derived peptide antigen => ECO:0000269|PubMed:23260142, ECO:0007744|PDB:4GBX
source Swiss-Prot : SWS_FT_FI6
48) chain D
residue 55
type SITE
sequence E
description Pathogen-derived peptide antigen => ECO:0000269|PubMed:23260142, ECO:0007744|PDB:4GBX
source Swiss-Prot : SWS_FT_FI6
49) chain G
residue 55
type SITE
sequence E
description Pathogen-derived peptide antigen => ECO:0000269|PubMed:23260142, ECO:0007744|PDB:4GBX
source Swiss-Prot : SWS_FT_FI6
50) chain J
residue 55
type SITE
sequence E
description Pathogen-derived peptide antigen => ECO:0000269|PubMed:23260142, ECO:0007744|PDB:4GBX
source Swiss-Prot : SWS_FT_FI6
51) chain A
residue 62
type SITE
sequence N
description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4GBX
source Swiss-Prot : SWS_FT_FI7
52) chain D
residue 62
type SITE
sequence N
description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4GBX
source Swiss-Prot : SWS_FT_FI7
53) chain G
residue 62
type SITE
sequence N
description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4GBX
source Swiss-Prot : SWS_FT_FI7
54) chain J
residue 62
type SITE
sequence N
description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4GBX
source Swiss-Prot : SWS_FT_FI7
55) chain A
residue 69
type SITE
sequence N
description Pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX
source Swiss-Prot : SWS_FT_FI8
56) chain D
residue 69
type SITE
sequence N
description Pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX
source Swiss-Prot : SWS_FT_FI8
57) chain G
residue 69
type SITE
sequence N
description Pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX
source Swiss-Prot : SWS_FT_FI8
58) chain J
residue 69
type SITE
sequence N
description Pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX
source Swiss-Prot : SWS_FT_FI8
59) chain A
residue 76
type SITE
sequence R
description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX
source Swiss-Prot : SWS_FT_FI9
60) chain D
residue 76
type SITE
sequence R
description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX
source Swiss-Prot : SWS_FT_FI9
61) chain G
residue 76
type SITE
sequence R
description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX
source Swiss-Prot : SWS_FT_FI9
62) chain J
residue 76
type SITE
sequence R
description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX
source Swiss-Prot : SWS_FT_FI9

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