eF-site ID 1aob-A PDB Code 1aob Chain A click to enlarge Title E. COLI THYMIDYLATE SYNTHASE COMPLEXED WITH DDURD Classification METHYLTRANSFERASE Compound THYMIDYLATE SYNTHASE Source Escherichia coli (strain K12) (TYSY_ECOLI) Sequence A:  MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQD GFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIW DEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLK NDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLS CQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFV WTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIF DYRFEDFEIEGYDPHPGIKAPVAI Description Functional site 1) chain A residue 146 type sequence C description ACTIVE SITE REACTIVE THIOL. source : ACT 2) chain A residue 21 type sequence R description BINDING SITE FOR RESIDUE PO4 A 300 source : AC1 3) chain A residue 126 type sequence R description BINDING SITE FOR RESIDUE PO4 A 300 source : AC1 4) chain A residue 127 type sequence R description BINDING SITE FOR RESIDUE PO4 A 300 source : AC1 5) chain A residue 166 type sequence R description BINDING SITE FOR RESIDUE PO4 A 300 source : AC1 6) chain A residue 146 type sequence C description BINDING SITE FOR RESIDUE DDU A 301 source : AC2 7) chain A residue 147 type sequence H description BINDING SITE FOR RESIDUE DDU A 301 source : AC2 8) chain A residue 165 type sequence Q description BINDING SITE FOR RESIDUE DDU A 301 source : AC2 9) chain A residue 167 type sequence S description BINDING SITE FOR RESIDUE DDU A 301 source : AC2 10) chain A residue 168 type sequence C description BINDING SITE FOR RESIDUE DDU A 301 source : AC2 11) chain A residue 169 type sequence D description BINDING SITE FOR RESIDUE DDU A 301 source : AC2 12) chain A residue 177 type sequence N description BINDING SITE FOR RESIDUE DDU A 301 source : AC2 13) chain A residue 207 type sequence H description BINDING SITE FOR RESIDUE DDU A 301 source : AC2 14) chain A residue 1 type sequence M description BINDING SITE FOR RESIDUE FMT A 302 source : AC3 15) chain A residue 45 type sequence V description BINDING SITE FOR RESIDUE FMT A 302 source : AC3 16) chain A residue 46 type sequence T description BINDING SITE FOR RESIDUE FMT A 302 source : AC3 17) chain A residue 47 type sequence T description BINDING SITE FOR RESIDUE FMT A 302 source : AC3 18) chain A residue 126-154 type prosite sequence RRIIVSAWNVGELDKMALAPCHAFFQFYV description THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RriIvsaWNvgeldkma.....LaPCHaffQFyV source prosite : PS00091 19) chain A residue 146 type ACT_SITE sequence C description Nucleophile => ECO:0000255|HAMAP-Rule:MF_00008, ECO:0000269|PubMed:2223754, ECO:0000269|PubMed:8973201, ECO:0000269|PubMed:9416600 source Swiss-Prot : SWS_FT_FI1 20) chain A residue 21 type BINDING sequence R description in other chain => ECO:0000269|PubMed:2223754, ECO:0000269|PubMed:8973201, ECO:0007744|PDB:1KCE, ECO:0007744|PDB:2TSC source Swiss-Prot : SWS_FT_FI2 21) chain A residue 166 type BINDING sequence R description in other chain => ECO:0000269|PubMed:2223754, ECO:0000269|PubMed:8973201, ECO:0007744|PDB:1KCE, ECO:0007744|PDB:2TSC source Swiss-Prot : SWS_FT_FI2 22) chain A residue 177 type BINDING sequence N description in other chain => ECO:0000269|PubMed:2223754, ECO:0000269|PubMed:8973201, ECO:0007744|PDB:1KCE, ECO:0007744|PDB:2TSC source Swiss-Prot : SWS_FT_FI2 23) chain A residue 207 type BINDING sequence H description in other chain => ECO:0000269|PubMed:2223754, ECO:0000269|PubMed:8973201, ECO:0007744|PDB:1KCE, ECO:0007744|PDB:2TSC source Swiss-Prot : SWS_FT_FI2 24) chain A residue 51 type BINDING sequence H description BINDING => ECO:0000305|PubMed:8312270, ECO:0007744|PDB:1TYS source Swiss-Prot : SWS_FT_FI3 25) chain A residue 169 type BINDING sequence D description BINDING => ECO:0000305|PubMed:8312270, ECO:0007744|PDB:1TYS source Swiss-Prot : SWS_FT_FI3 26) chain A residue 263 type BINDING sequence A description BINDING => ECO:0000305|PubMed:8312270, ECO:0007744|PDB:1TYS source Swiss-Prot : SWS_FT_FI3 27) chain A residue 126 type BINDING sequence R description BINDING => ECO:0000269|PubMed:2223754, ECO:0000269|PubMed:8973201, ECO:0007744|PDB:1KCE, ECO:0007744|PDB:2TSC source Swiss-Prot : SWS_FT_FI4

Display surface Download Links