eF-site ID 1alj-B PDB Code 1alj Chain B click to enlarge Title ALKALINE PHOSPHATASE MUTANT (H412N) Classification HYDROLASE (PHOSPHORIC MONOESTER) Compound ALKALINE PHOSPHATASE Source null (PPB_ECOLI) Sequence B:  MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAK NIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQ YTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVD IHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHV TSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVT LGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASL NSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPA VTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEG ASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTL VIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYG NSEEDSQENTGSQLRIAAYGPHAANVVGLTDQTDLFYTMK AALGLK Description Functional site 1) chain B residue 327 type sequence D description CATALYTICALLY ACTIVE SITE ON B SUBUNIT source : B 2) chain B residue 331 type sequence H description CATALYTICALLY ACTIVE SITE ON B SUBUNIT source : B 3) chain B residue 412 type sequence N description CATALYTICALLY ACTIVE SITE ON B SUBUNIT source : B 4) chain B residue 51 type sequence D description CATALYTICALLY ACTIVE SITE ON B SUBUNIT source : B 5) chain B residue 369 type sequence D description CATALYTICALLY ACTIVE SITE ON B SUBUNIT source : B 6) chain B residue 370 type sequence H description CATALYTICALLY ACTIVE SITE ON B SUBUNIT source : B 7) chain B residue 155 type sequence T description CATALYTICALLY ACTIVE SITE ON B SUBUNIT source : B 8) chain B residue 322 type sequence E description CATALYTICALLY ACTIVE SITE ON B SUBUNIT source : B 9) chain B residue 166 type sequence R description CATALYTICALLY ACTIVE SITE ON B SUBUNIT source : B 10) chain B residue 102 type sequence S description CATALYTICALLY ACTIVE SITE ON B SUBUNIT source : B 11) chain B residue 51 type sequence D description BINDING SITE FOR RESIDUE ZN B 451 source : AC4 12) chain B residue 102 type sequence S description BINDING SITE FOR RESIDUE ZN B 451 source : AC4 13) chain B residue 327 type sequence D description BINDING SITE FOR RESIDUE ZN B 451 source : AC4 14) chain B residue 369 type sequence D description BINDING SITE FOR RESIDUE ZN B 451 source : AC4 15) chain B residue 370 type sequence H description BINDING SITE FOR RESIDUE ZN B 451 source : AC4 16) chain B residue 51 type sequence D description BINDING SITE FOR RESIDUE MG B 452 source : AC5 17) chain B residue 153 type sequence D description BINDING SITE FOR RESIDUE MG B 452 source : AC5 18) chain B residue 155 type sequence T description BINDING SITE FOR RESIDUE MG B 452 source : AC5 19) chain B residue 322 type sequence E description BINDING SITE FOR RESIDUE MG B 452 source : AC5 20) chain B residue 101 type sequence D description BINDING SITE FOR RESIDUE PO4 B 453 source : AC6 21) chain B residue 102 type sequence S description BINDING SITE FOR RESIDUE PO4 B 453 source : AC6 22) chain B residue 166 type sequence R description BINDING SITE FOR RESIDUE PO4 B 453 source : AC6 23) chain B residue 327 type sequence D description BINDING SITE FOR RESIDUE PO4 B 453 source : AC6 24) chain B residue 331 type sequence H description BINDING SITE FOR RESIDUE PO4 B 453 source : AC6 25) chain B residue 370 type sequence H description BINDING SITE FOR RESIDUE PO4 B 453 source : AC6 26) chain B residue 412 type sequence N description BINDING SITE FOR RESIDUE PO4 B 453 source : AC6 27) chain B residue 51 type catalytic sequence D description 44 source MCSA : MCSA2 28) chain B residue 102 type catalytic sequence S description 44 source MCSA : MCSA2 29) chain B residue 153 type catalytic sequence D description 44 source MCSA : MCSA2 30) chain B residue 155 type catalytic sequence T description 44 source MCSA : MCSA2 31) chain B residue 166 type catalytic sequence R description 44 source MCSA : MCSA2 32) chain B residue 322 type catalytic sequence E description 44 source MCSA : MCSA2 33) chain B residue 327 type catalytic sequence D description 44 source MCSA : MCSA2 34) chain B residue 328 type catalytic sequence K description 44 source MCSA : MCSA2 35) chain B residue 331 type catalytic sequence H description 44 source MCSA : MCSA2 36) chain B residue 369 type catalytic sequence D description 44 source MCSA : MCSA2 37) chain B residue 370 type catalytic sequence H description 44 source MCSA : MCSA2 38) chain B residue 412 type catalytic sequence N description 44 source MCSA : MCSA2 39) chain B residue 102 type ACT_SITE sequence S description Phosphoserine intermediate source Swiss-Prot : SWS_FT_FI1 40) chain B residue 51 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 41) chain B residue 153 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 42) chain B residue 155 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI2 43) chain B residue 322 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 44) chain B residue 327 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 45) chain B residue 331 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 46) chain B residue 369 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 47) chain B residue 370 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 48) chain B residue 412 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI2

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