eF-site ID 1ako-A PDB Code 1ako Chain A click to enlarge Title EXONUCLEASE III FROM ESCHERICHIA COLI Classification NUCLEASE Compound EXONUCLEASE III Source Escherichia coli (strain K12) (EX3_ECOLI) Sequence A:  MKFVSFNINGLRARPHQLEAIVEKHQPDVIGLQETKVHDD MFPLEEVAKLGYNVFYHGQKGHYGVALLTKETPIAVRRGF PGDDEEAQRRIIMAEIPSLLGNVTVINGYFPQGESRDHPI KFPAKAQFYQNLQNYLETELKRDNPVLIMGDMNISPTDLD IGIGEENRKRWLRTGKCSFLPEEREWMDRLMSWGLVDTFR HANPQTADRFSWFDYRSKGFDDNRGLRIDLLLASQPLAEC CVETGIDYEIRSMEKPSDHAPVWATFRR Description Functional site 1) chain A residue 34 type sequence E description MG BINDING SITE. source : MG1 2) chain A residue 7 type catalytic sequence N description 160 source MCSA : MCSA1 3) chain A residue 34 type catalytic sequence E description 160 source MCSA : MCSA1 4) chain A residue 151 type catalytic sequence D description 160 source MCSA : MCSA1 5) chain A residue 153 type catalytic sequence N description 160 source MCSA : MCSA1 6) chain A residue 229 type catalytic sequence D description 160 source MCSA : MCSA1 7) chain A residue 258 type catalytic sequence D description 160 source MCSA : MCSA1 8) chain A residue 259 type catalytic sequence H description 160 source MCSA : MCSA1 9) chain A residue 27-36 type prosite sequence PDVIGLQETK description AP_NUCLEASE_F1_1 AP endonucleases family 1 signature 1. PDVIGLQETK source prosite : PS00726 10) chain A residue 197-213 type prosite sequence DTFRHANPQTADRFSWF description AP_NUCLEASE_F1_2 AP endonucleases family 1 signature 2. DTFRHanpqtadrFSWF source prosite : PS00727 11) chain A residue 223-234 type prosite sequence NRGLRIDLLLAS description AP_NUCLEASE_F1_3 AP endonucleases family 1 signature 3. NrGlRIDLlLaS source prosite : PS00728 12) chain A residue 109 type ACT_SITE sequence Y description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 13) chain A residue 151 type ACT_SITE sequence D description Proton donor/acceptor => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 14) chain A residue 34 type BINDING sequence E description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 15) chain A residue 151 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 16) chain A residue 153 type BINDING sequence N description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 17) chain A residue 258 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 18) chain A residue 153 type SITE sequence N description Transition state stabilizer => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 19) chain A residue 229 type SITE sequence D description Important for catalytic activity => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 20) chain A residue 259 type SITE sequence H description Interaction with DNA substrate => ECO:0000250 source Swiss-Prot : SWS_FT_FI6

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