eF-site ID 1ajv-A PDB Code 1ajv Chain A click to enlarge Title HIV-1 PROTEASE IN COMPLEX WITH THE CYCLIC SULFAMIDE INHIBITOR AHA006 Classification ASPARTYL PROTEASE Compound HIV-1 PROTEASE Source Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) (POL_HV1B1) Sequence A:  PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPG RWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPT PVNIIGRNLLTQIGCTLNF Description Functional site 1) chain A residue 25 type sequence D description BINDING SITE FOR RESIDUE NMB A 501 source : AC1 2) chain A residue 27 type sequence G description BINDING SITE FOR RESIDUE NMB A 501 source : AC1 3) chain A residue 28 type sequence A description BINDING SITE FOR RESIDUE NMB A 501 source : AC1 4) chain A residue 48 type sequence G description BINDING SITE FOR RESIDUE NMB A 501 source : AC1 5) chain A residue 49 type sequence G description BINDING SITE FOR RESIDUE NMB A 501 source : AC1 6) chain A residue 50 type sequence I description BINDING SITE FOR RESIDUE NMB A 501 source : AC1 7) chain A residue 82 type sequence V description BINDING SITE FOR RESIDUE NMB A 501 source : AC1 8) chain A residue 64 type SITE sequence I description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 9) chain A residue 64 type MOD_RES sequence I description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 10) chain A residue 22-33 type prosite sequence ALLDTGADDTVL description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL source prosite : PS00141

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