eF-site ID 1aix-H PDB Code 1aix Chain H click to enlarge Title HUMAN ALPHA-THROMBIN TERNARY COMPLEX WITH EXOSITE INHIBITOR HIRUGEN AND ACTIVE SITE INHIBITOR PHCH2OCO-D-DPA-PRO-BOROVAL Classification BLOOD COAGULATION/HYDROLASE INHIBITOR Compound ALPHA-THROMBIN (SMALL SUBUNIT) Source ORGANISM_COMMON: human; ORGANISM_SCIENTIFIC: Homo sapiens; Sequence H:  IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLT AAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISM LEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCL PDRETAASLLQAGYKGRVTGWGNLKETKGQPSVLQVVNLP IVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSG GPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRL KKWIQKVIDQF Description (1)  ALPHA-THROMBIN, HIRUGEN, PHENYLMETHYLENECARBOXY-(METHYLENEAMINO-FORMYL-DIPHENYLMETHYL)METHY-PRO-BOROVAL Functional site 1) chain H residue 57 type sequence H description BINDING SITE FOR RESIDUE T19 H 3 source : AC1 2) chain H residue 60 type sequence L description BINDING SITE FOR RESIDUE T19 H 3 source : AC1 3) chain H residue 97 type sequence R description BINDING SITE FOR RESIDUE T19 H 3 source : AC1 4) chain H residue 98 type sequence N description BINDING SITE FOR RESIDUE T19 H 3 source : AC1 5) chain H residue 191 type sequence C description BINDING SITE FOR RESIDUE T19 H 3 source : AC1 6) chain H residue 192 type sequence E description BINDING SITE FOR RESIDUE T19 H 3 source : AC1 7) chain H residue 195 type sequence S description BINDING SITE FOR RESIDUE T19 H 3 source : AC1 8) chain H residue 214 type sequence S description BINDING SITE FOR RESIDUE T19 H 3 source : AC1 9) chain H residue 215 type sequence W description BINDING SITE FOR RESIDUE T19 H 3 source : AC1 10) chain H residue 216 type sequence G description BINDING SITE FOR RESIDUE T19 H 3 source : AC1 11) chain H residue 217 type sequence E description BINDING SITE FOR RESIDUE T19 H 3 source : AC1 12) chain H residue 219 type sequence G description BINDING SITE FOR RESIDUE T19 H 3 source : AC1 13) chain H residue 34 type sequence F description BINDING SITE FOR CHAIN I OF HIRUGEN source : AC2 14) chain H residue 38 type sequence Q description BINDING SITE FOR CHAIN I OF HIRUGEN source : AC2 15) chain H residue 65 type sequence L description BINDING SITE FOR CHAIN I OF HIRUGEN source : AC2 16) chain H residue 67 type sequence R description BINDING SITE FOR CHAIN I OF HIRUGEN source : AC2 17) chain H residue 73 type sequence R description BINDING SITE FOR CHAIN I OF HIRUGEN source : AC2 18) chain H residue 74 type sequence T description BINDING SITE FOR CHAIN I OF HIRUGEN source : AC2 19) chain H residue 75 type sequence R description BINDING SITE FOR CHAIN I OF HIRUGEN source : AC2 20) chain H residue 76 type sequence Y description BINDING SITE FOR CHAIN I OF HIRUGEN source : AC2 21) chain H residue 80 type sequence E description BINDING SITE FOR CHAIN I OF HIRUGEN source : AC2 22) chain H residue 81 type sequence K description BINDING SITE FOR CHAIN I OF HIRUGEN source : AC2 23) chain H residue 82 type sequence I description BINDING SITE FOR CHAIN I OF HIRUGEN source : AC2 24) chain H residue 84 type sequence M description BINDING SITE FOR CHAIN I OF HIRUGEN source : AC2 25) chain H residue 195 type MOD_RES sequence S description Sulfotyrosine => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 26) chain H residue 60 type CARBOHYD sequence L description N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:873923 source Swiss-Prot : SWS_FT_FI2 27) chain H residue 53-58 type prosite sequence LTAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC source prosite : PS00134 28) chain H residue 189-200 type prosite sequence DACEGDSGGPFV description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV source prosite : PS00135

Display surface Download Links