eF-site ID 1agn-A PDB Code 1agn Chain A click to enlarge Title X-RAY STRUCTURE OF HUMAN SIGMA ALCOHOL DEHYDROGENASE Classification OXIDOREDUCTASE Compound HUMAN SIGMA ALCOHOL DEHYDROGENASE Source Homo sapiens (Human) (ADH7_HUMAN) Sequence A:  GTAGKVIKCKAAVLWEQKQPFSIEEIEVAPPKTKEVRIKI LATGICRTDDHVIKGTMVSKFPVIVGHEATGIVESIGEGV TTVKPGDKVIPLFLPQCRECNACRNPDGNLCIRSDITGRG VLADGTTRFTCKGKPVHHFMNTSTFTEYTVVDESSVAKID DAAPPEKVCLIGCGFSTGYGAAVKTGKVKPGSTCVVFGLG GVGLSVIMGCKSAGASRIIGIDLNKDKFEKAMAVGATECI SPKDSTKPISEVLSEMTGNNVGYTFEVIGHLETMIDALAS CHMNYGTSVVVGVPPSAKMLTYDPMLLFTGRTWKGCVFGG LKSRDDVPKLVTEFLAKKFDLDQLITHVLPFKKISEGFEL LNSGQSIRTVLTF Description Functional site 1) chain A residue 97 type sequence C description ZINC BINDING SITE source : ZN1 2) chain A residue 100 type sequence C description ZINC BINDING SITE source : ZN1 3) chain A residue 103 type sequence C description ZINC BINDING SITE source : ZN1 4) chain A residue 111 type sequence C description ZINC BINDING SITE source : ZN1 5) chain A residue 46 type sequence C description ZINC BINDING SITE source : ZN2 6) chain A residue 67 type sequence H description ZINC BINDING SITE source : ZN2 7) chain A residue 174 type sequence C description ZINC BINDING SITE source : ZN2 8) chain A residue 97 type sequence C description ZINC BINDING SITE source : ZN5 9) chain A residue 100 type sequence C description ZINC BINDING SITE source : ZN5 10) chain A residue 103 type sequence C description ZINC BINDING SITE source : ZN5 11) chain A residue 111 type sequence C description ZINC BINDING SITE source : ZN5 12) chain A residue 46 type sequence C description ZINC BINDING SITE source : ZN6 13) chain A residue 67 type sequence H description ZINC BINDING SITE source : ZN6 14) chain A residue 174 type sequence C description ZINC BINDING SITE source : ZN6 15) chain A residue 97 type sequence C description BINDING SITE FOR RESIDUE ZN A 375 source : AC1 16) chain A residue 100 type sequence C description BINDING SITE FOR RESIDUE ZN A 375 source : AC1 17) chain A residue 103 type sequence C description BINDING SITE FOR RESIDUE ZN A 375 source : AC1 18) chain A residue 111 type sequence C description BINDING SITE FOR RESIDUE ZN A 375 source : AC1 19) chain A residue 46 type sequence C description BINDING SITE FOR RESIDUE ZN A 376 source : AC2 20) chain A residue 48 type sequence T description BINDING SITE FOR RESIDUE ZN A 376 source : AC2 21) chain A residue 67 type sequence H description BINDING SITE FOR RESIDUE ZN A 376 source : AC2 22) chain A residue 174 type sequence C description BINDING SITE FOR RESIDUE ZN A 376 source : AC2 23) chain A residue 271 type sequence H description BINDING SITE FOR RESIDUE ZN A 401 source : AC3 24) chain A residue 48 type sequence T description BINDING SITE FOR RESIDUE ACT A 378 source : AC4 25) chain A residue 141 type sequence M description BINDING SITE FOR RESIDUE ACT A 378 source : AC4 26) chain A residue 271 type sequence H description BINDING SITE FOR RESIDUE ACT A 501 source : AC5 27) chain A residue 357 type sequence E description BINDING SITE FOR RESIDUE ACT A 502 source : AC6 28) chain A residue 360 type sequence E description BINDING SITE FOR RESIDUE ACT A 502 source : AC6 29) chain A residue 25 type sequence E description BINDING SITE FOR RESIDUE ZN D 402 source : CC5 30) chain A residue 46 type sequence C description BINDING SITE FOR RESIDUE NAD A 377 source : CC9 31) chain A residue 47 type sequence R description BINDING SITE FOR RESIDUE NAD A 377 source : CC9 32) chain A residue 48 type sequence T description BINDING SITE FOR RESIDUE NAD A 377 source : CC9 33) chain A residue 51 type sequence H description BINDING SITE FOR RESIDUE NAD A 377 source : CC9 34) chain A residue 174 type sequence C description BINDING SITE FOR RESIDUE NAD A 377 source : CC9 35) chain A residue 178 type sequence T description BINDING SITE FOR RESIDUE NAD A 377 source : CC9 36) chain A residue 200 type sequence L description BINDING SITE FOR RESIDUE NAD A 377 source : CC9 37) chain A residue 201 type sequence G description BINDING SITE FOR RESIDUE NAD A 377 source : CC9 38) chain A residue 202 type sequence G description BINDING SITE FOR RESIDUE NAD A 377 source : CC9 39) chain A residue 203 type sequence V description BINDING SITE FOR RESIDUE NAD A 377 source : CC9 40) chain A residue 223 type sequence D description BINDING SITE FOR RESIDUE NAD A 377 source : CC9 41) chain A residue 224 type sequence L description BINDING SITE FOR RESIDUE NAD A 377 source : CC9 42) chain A residue 228 type sequence K description BINDING SITE FOR RESIDUE NAD A 377 source : CC9 43) chain A residue 269 type sequence I description BINDING SITE FOR RESIDUE NAD A 377 source : CC9 44) chain A residue 270 type sequence G description BINDING SITE FOR RESIDUE NAD A 377 source : CC9 45) chain A residue 271 type sequence H description BINDING SITE FOR RESIDUE NAD A 377 source : CC9 46) chain A residue 292 type sequence V description BINDING SITE FOR RESIDUE NAD A 377 source : CC9 47) chain A residue 293 type sequence G description BINDING SITE FOR RESIDUE NAD A 377 source : CC9 48) chain A residue 294 type sequence V description BINDING SITE FOR RESIDUE NAD A 377 source : CC9 49) chain A residue 317 type sequence C description BINDING SITE FOR RESIDUE NAD A 377 source : CC9 50) chain A residue 319 type sequence F description BINDING SITE FOR RESIDUE NAD A 377 source : CC9 51) chain A residue 369 type sequence R description BINDING SITE FOR RESIDUE NAD A 377 source : CC9 52) chain A residue 309 type sequence F description BINDING SITE FOR RESIDUE NAD B 377 source : DC1 53) chain A residue 58 type BINDING sequence V description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 54) chain A residue 235 type BINDING sequence V description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 55) chain A residue 240 type BINDING sequence C description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 56) chain A residue 281 type BINDING sequence S description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 57) chain A residue 304 type BINDING sequence D description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 58) chain A residue 329 type BINDING sequence P description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 59) chain A residue 59 type BINDING sequence S description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 60) chain A residue 79 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 61) chain A residue 109 type BINDING sequence N description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 62) chain A residue 112 type BINDING sequence I description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 63) chain A residue 115 type BINDING sequence D description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 64) chain A residue 124 type BINDING sequence A description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 65) chain A residue 186 type BINDING sequence T description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 66) chain A residue 211 type BINDING sequence C description BINDING => ECO:0000269|PubMed:10631979, ECO:0007744|PDB:1AGN, ECO:0007744|PDB:1D1S, ECO:0007744|PDB:1D1T source Swiss-Prot : SWS_FT_FI1 67) chain A residue 66-80 type prosite sequence GHEATGIVESIGEGV description ADH_ZINC Zinc-containing alcohol dehydrogenases signature. GHEaTGIvesiGegV source prosite : PS00059

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