eF-site ID 1afw-AB PDB Code 1afw Chain A, B click to enlarge Title THE 1.8 ANGSTROM CRYSTAL STRUCTURE OF THE DIMERIC PEROXISOMAL THIOLASE OF SACCHAROMYCES CEREVISIAE Classification THIOLASE Compound 3-KETOACETYL-COA THIOLASE Source ORGANISM_COMMON: baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; Sequence A:  KNSLLEKRPEDVVIVAANRSAIGKGFKGAFKDVNTDYLLY NFLNEFIGRFPEPLRADLNLIEEVACGNVLNVGAGATEHR AACLASGIPYSTPFVALNRQCSSGLTAVNDIANKIKVGQI DIGLALGVESMTNNYKNVNPLGMISSEELQKNREAKKCLI PMGITNENVAANFKISRKDQDEFAANSYQKAYKAKNEGLF EDEILPIKLPDGSICQSDEGPRPNVTAESLSSIRPAFIGT TTAGNASQVSDGVAGVLLARRSVANQLNLPVLGRYIDFQT VGVPPEIMGVGPAYAIPKVLEATGLQVQDIDIFEINEAFA AQALYCIHKLGIDLNKVNPRGGAIALGHPLGCTGARQVAT ILRELKKDQIGVVSMCIGTGMGAAAIFIKE B:  KNSLLEKRPEDVVIVAANRSAIGKGFKGAFKDVNTDYLLY NFLNEFIGRFPEPLRADLNLIEEVACGNVLNVGAGATEHR AACLASGIPYSTPFVALNRQCSSGLTAVNDIANKIKVGQI DIGLALGVESMTNNYKNVNPLGMISSEELQKNREAKKCLI PMGITNENVAANFKISRKDQDEFAANSYQKAYKAKNEGLF EDEILPIKLPDGSICQSDEGPRPNVTAESLSSIRPAFIKD RGTTTAGNASQVSDGVAGVLLARRSVANQLNLPVLGRYID FQTVGVPPEIMGVGPAYAIPKVLEATGLQVQDIDIFEINE AFAAQALYCIHKLGIDLNKVNPRGGAIALGHPLGCTGARQ VATILRELKKDQIGVVSMCIGTGMGAAAIFIKE Description Functional site 1) chain A residue 125 type sequence C description ACTIVE SITE IN CHAIN A. source : AVA 2) chain A residue 375 type sequence H description ACTIVE SITE IN CHAIN A. source : AVA 3) chain A residue 403 type sequence C description ACTIVE SITE IN CHAIN A. source : AVA 4) chain B residue 125 type sequence C description ACTIVE SITE IN CHAIN B. source : AVB 5) chain B residue 375 type sequence H description ACTIVE SITE IN CHAIN B. source : AVB 6) chain B residue 403 type sequence C description ACTIVE SITE IN CHAIN B. source : AVB 7) chain A residue 124 type sequence Q description BINDING SITE FOR RESIDUE MRD A 501 source : AC1 8) chain A residue 182 type sequence C description BINDING SITE FOR RESIDUE MRD A 501 source : AC1 9) chain A residue 183 type sequence L description BINDING SITE FOR RESIDUE MRD A 501 source : AC1 10) chain A residue 184 type sequence I description BINDING SITE FOR RESIDUE MRD A 501 source : AC1 11) chain B residue 124 type sequence Q description BINDING SITE FOR RESIDUE MRD B 502 source : AC2 12) chain B residue 182 type sequence C description BINDING SITE FOR RESIDUE MRD B 502 source : AC2 13) chain B residue 183 type sequence L description BINDING SITE FOR RESIDUE MRD B 502 source : AC2 14) chain B residue 184 type sequence I description BINDING SITE FOR RESIDUE MRD B 502 source : AC2 15) chain A residue 125 type ACT_SITE sequence C description Acyl-thioester intermediate source Swiss-Prot : SWS_FT_FI1 16) chain B residue 125 type ACT_SITE sequence C description Acyl-thioester intermediate source Swiss-Prot : SWS_FT_FI1 17) chain A residue 125 type catalytic sequence C description 77 source MCSA : MCSA1 18) chain A residue 375 type catalytic sequence H description 77 source MCSA : MCSA1 19) chain A residue 403 type catalytic sequence C description 77 source MCSA : MCSA1 20) chain A residue 405 type catalytic sequence G description 77 source MCSA : MCSA1 21) chain B residue 125 type catalytic sequence C description 77 source MCSA : MCSA2 22) chain B residue 375 type catalytic sequence H description 77 source MCSA : MCSA2 23) chain B residue 403 type catalytic sequence C description 77 source MCSA : MCSA2 24) chain B residue 405 type catalytic sequence G description 77 source MCSA : MCSA2 25) chain A residue 375 type ACT_SITE sequence H description Proton acceptor source Swiss-Prot : SWS_FT_FI2 26) chain A residue 403 type ACT_SITE sequence C description Proton acceptor source Swiss-Prot : SWS_FT_FI2 27) chain B residue 375 type ACT_SITE sequence H description Proton acceptor source Swiss-Prot : SWS_FT_FI2 28) chain B residue 403 type ACT_SITE sequence C description Proton acceptor source Swiss-Prot : SWS_FT_FI2 29) chain A residue 121-139 type prosite sequence LNRQCSSGLTAVNDIANKI description THIOLASE_1 Thiolases acyl-enzyme intermediate signature. LNRqCSSGLtAVndiankI source prosite : PS00098 30) chain A residue 398-411 type prosite sequence GVVSMCIGTGMGAA description THIOLASE_3 Thiolases active site. GVVSMCIGtGmGaA source prosite : PS00099 31) chain A residue 365-381 type prosite sequence NPRGGAIALGHPLGCTG description THIOLASE_2 Thiolases signature 2. NprGGaIAlGHPlGcTG source prosite : PS00737

Display surface Download Links