eF-site ID 1afw-A PDB Code 1afw Chain A click to enlarge Title THE 1.8 ANGSTROM CRYSTAL STRUCTURE OF THE DIMERIC PEROXISOMAL THIOLASE OF SACCHAROMYCES CEREVISIAE Classification THIOLASE Compound 3-KETOACETYL-COA THIOLASE Source ORGANISM_COMMON: baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; Sequence A:  KNSLLEKRPEDVVIVAANRSAIGKGFKGAFKDVNTDYLLY NFLNEFIGRFPEPLRADLNLIEEVACGNVLNVGAGATEHR AACLASGIPYSTPFVALNRQCSSGLTAVNDIANKIKVGQI DIGLALGVESMTNNYKNVNPLGMISSEELQKNREAKKCLI PMGITNENVAANFKISRKDQDEFAANSYQKAYKAKNEGLF EDEILPIKLPDGSICQSDEGPRPNVTAESLSSIRPAFIGT TTAGNASQVSDGVAGVLLARRSVANQLNLPVLGRYIDFQT VGVPPEIMGVGPAYAIPKVLEATGLQVQDIDIFEINEAFA AQALYCIHKLGIDLNKVNPRGGAIALGHPLGCTGARQVAT ILRELKKDQIGVVSMCIGTGMGAAAIFIKE Description Functional site 1) chain A residue 125 type sequence C description ACTIVE SITE IN CHAIN A. source : AVA 2) chain A residue 375 type sequence H description ACTIVE SITE IN CHAIN A. source : AVA 3) chain A residue 403 type sequence C description ACTIVE SITE IN CHAIN A. source : AVA 4) chain A residue 124 type sequence Q description BINDING SITE FOR RESIDUE MRD A 501 source : AC1 5) chain A residue 182 type sequence C description BINDING SITE FOR RESIDUE MRD A 501 source : AC1 6) chain A residue 183 type sequence L description BINDING SITE FOR RESIDUE MRD A 501 source : AC1 7) chain A residue 184 type sequence I description BINDING SITE FOR RESIDUE MRD A 501 source : AC1 8) chain A residue 125 type catalytic sequence C description 77 source MCSA : MCSA1 9) chain A residue 375 type catalytic sequence H description 77 source MCSA : MCSA1 10) chain A residue 403 type catalytic sequence C description 77 source MCSA : MCSA1 11) chain A residue 405 type catalytic sequence G description 77 source MCSA : MCSA1 12) chain A residue 121-139 type prosite sequence LNRQCSSGLTAVNDIANKI description THIOLASE_1 Thiolases acyl-enzyme intermediate signature. LNRqCSSGLtAVndiankI source prosite : PS00098 13) chain A residue 398-411 type prosite sequence GVVSMCIGTGMGAA description THIOLASE_3 Thiolases active site. GVVSMCIGtGmGaA source prosite : PS00099 14) chain A residue 365-381 type prosite sequence NPRGGAIALGHPLGCTG description THIOLASE_2 Thiolases signature 2. NprGGaIAlGHPlGcTG source prosite : PS00737 15) chain A residue 125 type ACT_SITE sequence C description Acyl-thioester intermediate source Swiss-Prot : SWS_FT_FI1 16) chain A residue 375 type ACT_SITE sequence H description Proton acceptor source Swiss-Prot : SWS_FT_FI2 17) chain A residue 403 type ACT_SITE sequence C description Proton acceptor source Swiss-Prot : SWS_FT_FI2

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