eF-site ID 1aec-A PDB Code 1aec Chain A click to enlarge Title CRYSTAL STRUCTURE OF ACTINIDIN-E-64 COMPLEX+ Classification HYDROLASE Compound ACTINIDIN Source Actinidia chinensis (Kiwi) (Yangtao) (ACTN_ACTCH) Sequence A:  LPSYVDWRSAGAVVDIKSQGECGGCWAFSAIATVEGINKI VTGVLISLSEQELIDCGRTQNTRGCNGGYITDGFQFIINN GGINTEENYPYTAQDGECNVDLQNEKYVTIDTYENVPYNN EWALQTAVTYQPVSVALDAAGDAFKQYSSGIFTGPCGTAI DHAVTIVGYGTEGGIDYWIVKNSWDTTWGEEGYMRILRNV GGAGTCGIATMPSYPVKY Description (1)  ACTINIDIN (E.C.3.4.22.14) COMPLEX WITH THE INHIBITOR ([N-(L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYL]-AMIDO(4-GUANIDO)BUTANE) (E-64) Functional site 1) chain A residue 19 type sequence Q description BINDING SITE FOR RESIDUE E64 A 219 source : AC1 2) chain A residue 23 type sequence G description BINDING SITE FOR RESIDUE E64 A 219 source : AC1 3) chain A residue 24 type sequence G description BINDING SITE FOR RESIDUE E64 A 219 source : AC1 4) chain A residue 25 type sequence C description BINDING SITE FOR RESIDUE E64 A 219 source : AC1 5) chain A residue 26 type sequence W description BINDING SITE FOR RESIDUE E64 A 219 source : AC1 6) chain A residue 61 type sequence N description BINDING SITE FOR RESIDUE E64 A 219 source : AC1 7) chain A residue 63 type sequence R description BINDING SITE FOR RESIDUE E64 A 219 source : AC1 8) chain A residue 66 type sequence N description BINDING SITE FOR RESIDUE E64 A 219 source : AC1 9) chain A residue 67 type sequence G description BINDING SITE FOR RESIDUE E64 A 219 source : AC1 10) chain A residue 68 type sequence G description BINDING SITE FOR RESIDUE E64 A 219 source : AC1 11) chain A residue 69 type sequence Y description BINDING SITE FOR RESIDUE E64 A 219 source : AC1 12) chain A residue 88 type sequence N description BINDING SITE FOR RESIDUE E64 A 219 source : AC1 13) chain A residue 161 type sequence D description BINDING SITE FOR RESIDUE E64 A 219 source : AC1 14) chain A residue 162 type sequence H description BINDING SITE FOR RESIDUE E64 A 219 source : AC1 15) chain A residue 162 type ACT_SITE sequence H description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10089 source Swiss-Prot : SWS_FT_FI2 16) chain A residue 182 type ACT_SITE sequence N description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10090 source Swiss-Prot : SWS_FT_FI3 17) chain A residue 25 type BINDING sequence C description covalent => ECO:0000269|PubMed:1606141, ECO:0007744|PDB:1AEC source Swiss-Prot : SWS_FT_FI4 18) chain A residue 25 type ACT_SITE sequence C description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10088, ECO:0000305|PubMed:1606141, ECO:0007744|PDB:1AEC source Swiss-Prot : SWS_FT_FI1 19) chain A residue 19-30 type prosite sequence QGECGGCWAFSA description THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGeCGGCWAfSA source prosite : PS00139 20) chain A residue 160-170 type prosite sequence IDHAVTIVGYG description THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. IDHAVTIVGYG source prosite : PS00639 21) chain A residue 177-196 type prosite sequence YWIVKNSWDTTWGEEGYMRI description THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWIvKNSWdttWGeeGYMrI source prosite : PS00640

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