eF-site/Summary 1adb-A

eF-site ID	1adb-A
PDB Code	1adb
Chain	A

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Title	CRYSTALLOGRAPHIC STUDIES OF ISOSTERIC NAD ANALOGUES BOUND TO ALCOHOL DEHYDROGENASE: SPECIFICITY AND SUBSTRATE BINDING IN TWO TERNARY COMPLEXES
Classification	OXIDOREDUCTASE (NAD(A)-CHOH(D))
Compound	ALCOHOL DEHYDROGENASE
Source	Equus caballus (Horse) (ADHE_HORSE)

Sequence	A:	STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKM VATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGV TTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPR GTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKI DAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGL GGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATEC VNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALS CCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFG GFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFD LLRSGESIRTILTF

Description

Functional site


1)	chain	A
	residue	46
	type
	sequence	C
	description
	source	: DMA

2)	chain	A
	residue	48
	type
	sequence	S
	description
	source	: DMA

3)	chain	A
	residue	67
	type
	sequence	H
	description
	source	: DMA

4)	chain	A
	residue	93
	type
	sequence	F
	description
	source	: DMA

5)	chain	A
	residue	141
	type
	sequence	L
	description
	source	: DMA

6)	chain	A
	residue	174
	type
	sequence	C
	description
	source	: DMA

7)	chain	A
	residue	1
	type
	sequence	S
	description
	source	: DMA

8)	chain	A
	residue	3
	type
	sequence	A
	description
	source	: DMA

9)	chain	A
	residue	47
	type
	sequence	R
	description
	source	: NAA

10)	chain	A
	residue	51
	type
	sequence	H
	description
	source	: NAA

11)	chain	A
	residue	178
	type
	sequence	T
	description
	source	: NAA

12)	chain	A
	residue	198
	type
	sequence	F
	description
	source	: NAA

13)	chain	A
	residue	199
	type
	sequence	G
	description
	source	: NAA

14)	chain	A
	residue	200
	type
	sequence	L
	description
	source	: NAA

15)	chain	A
	residue	202
	type
	sequence	G
	description
	source	: NAA

16)	chain	A
	residue	203
	type
	sequence	V
	description
	source	: NAA

17)	chain	A
	residue	222
	type
	sequence	V
	description
	source	: NAA

18)	chain	A
	residue	223
	type
	sequence	D
	description
	source	: NAA

19)	chain	A
	residue	224
	type
	sequence	I
	description
	source	: NAA

20)	chain	A
	residue	228
	type
	sequence	K
	description
	source	: NAA

21)	chain	A
	residue	269
	type
	sequence	I
	description
	source	: NAA

22)	chain	A
	residue	270
	type
	sequence	G
	description
	source	: NAA

23)	chain	A
	residue	271
	type
	sequence	R
	description
	source	: NAA

24)	chain	A
	residue	292
	type
	sequence	V
	description
	source	: NAA

25)	chain	A
	residue	293
	type
	sequence	G
	description
	source	: NAA

26)	chain	A
	residue	294
	type
	sequence	V
	description
	source	: NAA

27)	chain	A
	residue	319
	type
	sequence	F
	description
	source	: NAA

28)	chain	A
	residue	369
	type
	sequence	R
	description
	source	: NAA

29)	chain	A
	residue	46
	type
	sequence	C
	description	BINDING SITE FOR RESIDUE ZN A 375
	source	: AC1

30)	chain	A
	residue	67
	type
	sequence	H
	description	BINDING SITE FOR RESIDUE ZN A 375
	source	: AC1

31)	chain	A
	residue	174
	type
	sequence	C
	description	BINDING SITE FOR RESIDUE ZN A 375
	source	: AC1

32)	chain	A
	residue	97
	type
	sequence	C
	description	BINDING SITE FOR RESIDUE ZN A 376
	source	: AC2

33)	chain	A
	residue	100
	type
	sequence	C
	description	BINDING SITE FOR RESIDUE ZN A 376
	source	: AC2

34)	chain	A
	residue	103
	type
	sequence	C
	description	BINDING SITE FOR RESIDUE ZN A 376
	source	: AC2

35)	chain	A
	residue	111
	type
	sequence	C
	description	BINDING SITE FOR RESIDUE ZN A 376
	source	: AC2

36)	chain	A
	residue	46
	type
	sequence	C
	description	BINDING SITE FOR RESIDUE CND A 377
	source	: AC5

37)	chain	A
	residue	47
	type
	sequence	R
	description	BINDING SITE FOR RESIDUE CND A 377
	source	: AC5

38)	chain	A
	residue	48
	type
	sequence	S
	description	BINDING SITE FOR RESIDUE CND A 377
	source	: AC5

39)	chain	A
	residue	51
	type
	sequence	H
	description	BINDING SITE FOR RESIDUE CND A 377
	source	: AC5

40)	chain	A
	residue	174
	type
	sequence	C
	description	BINDING SITE FOR RESIDUE CND A 377
	source	: AC5

41)	chain	A
	residue	199
	type
	sequence	G
	description	BINDING SITE FOR RESIDUE CND A 377
	source	: AC5

42)	chain	A
	residue	201
	type
	sequence	G
	description	BINDING SITE FOR RESIDUE CND A 377
	source	: AC5

43)	chain	A
	residue	202
	type
	sequence	G
	description	BINDING SITE FOR RESIDUE CND A 377
	source	: AC5

44)	chain	A
	residue	203
	type
	sequence	V
	description	BINDING SITE FOR RESIDUE CND A 377
	source	: AC5

45)	chain	A
	residue	223
	type
	sequence	D
	description	BINDING SITE FOR RESIDUE CND A 377
	source	: AC5

46)	chain	A
	residue	224
	type
	sequence	I
	description	BINDING SITE FOR RESIDUE CND A 377
	source	: AC5

47)	chain	A
	residue	228
	type
	sequence	K
	description	BINDING SITE FOR RESIDUE CND A 377
	source	: AC5

48)	chain	A
	residue	268
	type
	sequence	V
	description	BINDING SITE FOR RESIDUE CND A 377
	source	: AC5

49)	chain	A
	residue	269
	type
	sequence	I
	description	BINDING SITE FOR RESIDUE CND A 377
	source	: AC5

50)	chain	A
	residue	292
	type
	sequence	V
	description	BINDING SITE FOR RESIDUE CND A 377
	source	: AC5

51)	chain	A
	residue	293
	type
	sequence	G
	description	BINDING SITE FOR RESIDUE CND A 377
	source	: AC5

52)	chain	A
	residue	294
	type
	sequence	V
	description	BINDING SITE FOR RESIDUE CND A 377
	source	: AC5

53)	chain	A
	residue	317
	type
	sequence	A
	description	BINDING SITE FOR RESIDUE CND A 377
	source	: AC5

54)	chain	A
	residue	318
	type
	sequence	I
	description	BINDING SITE FOR RESIDUE CND A 377
	source	: AC5

55)	chain	A
	residue	319
	type
	sequence	F
	description	BINDING SITE FOR RESIDUE CND A 377
	source	: AC5

56)	chain	A
	residue	369
	type
	sequence	R
	description	BINDING SITE FOR RESIDUE CND A 377
	source	: AC5

57)	chain	A
	residue	48
	type
	sequence	S
	description	BINDING SITE FOR RESIDUE EOH A 378
	source	: AC7

58)	chain	A
	residue	93
	type
	sequence	F
	description	BINDING SITE FOR RESIDUE EOH A 378
	source	: AC7

59)	chain	A
	residue	47
	type	catalytic
	sequence	R
	description	256
	source	MCSA : MCSA1

60)	chain	A
	residue	49
	type	catalytic
	sequence	D
	description	256
	source	MCSA : MCSA1

61)	chain	A
	residue	52
	type	catalytic
	sequence	V
	description	256
	source	MCSA : MCSA1

62)	chain	A
	residue	68
	type	catalytic
	sequence	E
	description	256
	source	MCSA : MCSA1

63)	chain	A
	residue	175
	type	catalytic
	sequence	G
	description	256
	source	MCSA : MCSA1

64)	chain	A
	residue	229
	type	BINDING
	sequence	F
	description	BINDING => ECO:0000269\|PubMed:15299346, ECO:0007744\|PDB:1A71, ECO:0007744\|PDB:1ADB, ECO:0007744\|PDB:1AXE, ECO:0007744\|PDB:1AXG, ECO:0007744\|PDB:1BTO, ECO:0007744\|PDB:1HET, ECO:0007744\|PDB:1HEU, ECO:0007744\|PDB:1HF3, ECO:0007744\|PDB:1HLD, ECO:0007744\|PDB:1JU9, ECO:0007744\|PDB:1LDE, ECO:0007744\|PDB:1MGO, ECO:0007744\|PDB:1N8K, ECO:0007744\|PDB:1N92, ECO:0007744\|PDB:1QLH, ECO:0007744\|PDB:2JHF, ECO:0007744\|PDB:2JHG, ECO:0007744\|PDB:2OHX, ECO:0007744\|PDB:2OXI, ECO:0007744\|PDB:3OQ6, ECO:0007744\|PDB:4DWV, ECO:0007744\|PDB:4DXH, ECO:0007744\|PDB:4NFH, ECO:0007744\|PDB:4NFS, ECO:0007744\|PDB:4NG5, ECO:0007744\|PDB:4XD2, ECO:0007744\|PDB:5ADH, ECO:0007744\|PDB:6ADH
	source	Swiss-Prot : SWS_FT_FI7

65)	chain	A
	residue	47
	type	BINDING
	sequence	R
	description	BINDING => ECO:0000269\|PubMed:15299346, ECO:0000269\|PubMed:178875, ECO:0007744\|PDB:1A71, ECO:0007744\|PDB:1A72, ECO:0007744\|PDB:1ADB, ECO:0007744\|PDB:1ADC, ECO:0007744\|PDB:1ADF, ECO:0007744\|PDB:1ADG, ECO:0007744\|PDB:1AXE, ECO:0007744\|PDB:1AXG, ECO:0007744\|PDB:1BTO, ECO:0007744\|PDB:1HET, ECO:0007744\|PDB:1HLD, ECO:0007744\|PDB:1JU9, ECO:0007744\|PDB:1LDE, ECO:0007744\|PDB:1LDY, ECO:0007744\|PDB:1MG0, ECO:0007744\|PDB:1MGO, ECO:0007744\|PDB:1N8K, ECO:0007744\|PDB:1N92, ECO:0007744\|PDB:1P1R, ECO:0007744\|PDB:1QLH, ECO:0007744\|PDB:1QLJ, ECO:0007744\|PDB:1QV6, ECO:0007744\|PDB:1QV7, ECO:0007744\|PDB:1YE3, ECO:0007744\|PDB:2JHG, ECO:0007744\|PDB:2OHX, ECO:0007744\|PDB:3BTO, ECO:0007744\|PDB:3OQ6, ECO:0007744\|PDB:4DWV, ECO:0007744\|PDB:4DXH, ECO:0007744\|PDB:4NFH, ECO:0007744\|PDB:4NFS, ECO:0007744\|PDB:4NG5, ECO:0007744\|PDB:4XD2, ECO:0007744\|PDB:5ADH, ECO:0007744\|PDB:6ADH, ECO:0007744\|PDB:7ADH, ECO:0007744\|PDB:8ADH
	source	Swiss-Prot : SWS_FT_FI1

66)	chain	A
	residue	68
	type	BINDING
	sequence	E
	description	BINDING => ECO:0000269\|PubMed:15299346, ECO:0000269\|PubMed:178875, ECO:0007744\|PDB:1A71, ECO:0007744\|PDB:1A72, ECO:0007744\|PDB:1ADB, ECO:0007744\|PDB:1ADC, ECO:0007744\|PDB:1ADF, ECO:0007744\|PDB:1ADG, ECO:0007744\|PDB:1AXE, ECO:0007744\|PDB:1AXG, ECO:0007744\|PDB:1BTO, ECO:0007744\|PDB:1HET, ECO:0007744\|PDB:1HLD, ECO:0007744\|PDB:1JU9, ECO:0007744\|PDB:1LDE, ECO:0007744\|PDB:1LDY, ECO:0007744\|PDB:1MG0, ECO:0007744\|PDB:1MGO, ECO:0007744\|PDB:1N8K, ECO:0007744\|PDB:1N92, ECO:0007744\|PDB:1P1R, ECO:0007744\|PDB:1QLH, ECO:0007744\|PDB:1QLJ, ECO:0007744\|PDB:1QV6, ECO:0007744\|PDB:1QV7, ECO:0007744\|PDB:1YE3, ECO:0007744\|PDB:2JHG, ECO:0007744\|PDB:2OHX, ECO:0007744\|PDB:3BTO, ECO:0007744\|PDB:3OQ6, ECO:0007744\|PDB:4DWV, ECO:0007744\|PDB:4DXH, ECO:0007744\|PDB:4NFH, ECO:0007744\|PDB:4NFS, ECO:0007744\|PDB:4NG5, ECO:0007744\|PDB:4XD2, ECO:0007744\|PDB:5ADH, ECO:0007744\|PDB:6ADH, ECO:0007744\|PDB:7ADH, ECO:0007744\|PDB:8ADH
	source	Swiss-Prot : SWS_FT_FI1

67)	chain	A
	residue	98
	type	BINDING
	sequence	G
	description	BINDING => ECO:0000269\|PubMed:15299346, ECO:0000269\|PubMed:178875, ECO:0007744\|PDB:1A71, ECO:0007744\|PDB:1A72, ECO:0007744\|PDB:1ADB, ECO:0007744\|PDB:1ADC, ECO:0007744\|PDB:1ADF, ECO:0007744\|PDB:1ADG, ECO:0007744\|PDB:1AXE, ECO:0007744\|PDB:1AXG, ECO:0007744\|PDB:1BTO, ECO:0007744\|PDB:1HET, ECO:0007744\|PDB:1HLD, ECO:0007744\|PDB:1JU9, ECO:0007744\|PDB:1LDE, ECO:0007744\|PDB:1LDY, ECO:0007744\|PDB:1MG0, ECO:0007744\|PDB:1MGO, ECO:0007744\|PDB:1N8K, ECO:0007744\|PDB:1N92, ECO:0007744\|PDB:1P1R, ECO:0007744\|PDB:1QLH, ECO:0007744\|PDB:1QLJ, ECO:0007744\|PDB:1QV6, ECO:0007744\|PDB:1QV7, ECO:0007744\|PDB:1YE3, ECO:0007744\|PDB:2JHG, ECO:0007744\|PDB:2OHX, ECO:0007744\|PDB:2OXI, ECO:0007744\|PDB:3BTO, ECO:0007744\|PDB:3OQ6, ECO:0007744\|PDB:4DWV, ECO:0007744\|PDB:4DXH, ECO:0007744\|PDB:4NFH, ECO:0007744\|PDB:4NFS, ECO:0007744\|PDB:4NG5, ECO:0007744\|PDB:4XD2, ECO:0007744\|PDB:5ADH, ECO:0007744\|PDB:6ADH, ECO:0007744\|PDB:7ADH, ECO:0007744\|PDB:8ADH
	source	Swiss-Prot : SWS_FT_FI3

68)	chain	A
	residue	101
	type	BINDING
	sequence	R
	description	BINDING => ECO:0000269\|PubMed:15299346, ECO:0000269\|PubMed:178875, ECO:0007744\|PDB:1A71, ECO:0007744\|PDB:1A72, ECO:0007744\|PDB:1ADB, ECO:0007744\|PDB:1ADC, ECO:0007744\|PDB:1ADF, ECO:0007744\|PDB:1ADG, ECO:0007744\|PDB:1AXE, ECO:0007744\|PDB:1AXG, ECO:0007744\|PDB:1BTO, ECO:0007744\|PDB:1HET, ECO:0007744\|PDB:1HLD, ECO:0007744\|PDB:1JU9, ECO:0007744\|PDB:1LDE, ECO:0007744\|PDB:1LDY, ECO:0007744\|PDB:1MG0, ECO:0007744\|PDB:1MGO, ECO:0007744\|PDB:1N8K, ECO:0007744\|PDB:1N92, ECO:0007744\|PDB:1P1R, ECO:0007744\|PDB:1QLH, ECO:0007744\|PDB:1QLJ, ECO:0007744\|PDB:1QV6, ECO:0007744\|PDB:1QV7, ECO:0007744\|PDB:1YE3, ECO:0007744\|PDB:2JHG, ECO:0007744\|PDB:2OHX, ECO:0007744\|PDB:2OXI, ECO:0007744\|PDB:3BTO, ECO:0007744\|PDB:3OQ6, ECO:0007744\|PDB:4DWV, ECO:0007744\|PDB:4DXH, ECO:0007744\|PDB:4NFH, ECO:0007744\|PDB:4NFS, ECO:0007744\|PDB:4NG5, ECO:0007744\|PDB:4XD2, ECO:0007744\|PDB:5ADH, ECO:0007744\|PDB:6ADH, ECO:0007744\|PDB:7ADH, ECO:0007744\|PDB:8ADH
	source	Swiss-Prot : SWS_FT_FI3

69)	chain	A
	residue	104
	type	BINDING
	sequence	K
	description	BINDING => ECO:0000269\|PubMed:15299346, ECO:0000269\|PubMed:178875, ECO:0007744\|PDB:1A71, ECO:0007744\|PDB:1A72, ECO:0007744\|PDB:1ADB, ECO:0007744\|PDB:1ADC, ECO:0007744\|PDB:1ADF, ECO:0007744\|PDB:1ADG, ECO:0007744\|PDB:1AXE, ECO:0007744\|PDB:1AXG, ECO:0007744\|PDB:1BTO, ECO:0007744\|PDB:1HET, ECO:0007744\|PDB:1HLD, ECO:0007744\|PDB:1JU9, ECO:0007744\|PDB:1LDE, ECO:0007744\|PDB:1LDY, ECO:0007744\|PDB:1MG0, ECO:0007744\|PDB:1MGO, ECO:0007744\|PDB:1N8K, ECO:0007744\|PDB:1N92, ECO:0007744\|PDB:1P1R, ECO:0007744\|PDB:1QLH, ECO:0007744\|PDB:1QLJ, ECO:0007744\|PDB:1QV6, ECO:0007744\|PDB:1QV7, ECO:0007744\|PDB:1YE3, ECO:0007744\|PDB:2JHG, ECO:0007744\|PDB:2OHX, ECO:0007744\|PDB:2OXI, ECO:0007744\|PDB:3BTO, ECO:0007744\|PDB:3OQ6, ECO:0007744\|PDB:4DWV, ECO:0007744\|PDB:4DXH, ECO:0007744\|PDB:4NFH, ECO:0007744\|PDB:4NFS, ECO:0007744\|PDB:4NG5, ECO:0007744\|PDB:4XD2, ECO:0007744\|PDB:5ADH, ECO:0007744\|PDB:6ADH, ECO:0007744\|PDB:7ADH, ECO:0007744\|PDB:8ADH
	source	Swiss-Prot : SWS_FT_FI3

70)	chain	A
	residue	112
	type	BINDING
	sequence	L
	description	BINDING => ECO:0000269\|PubMed:15299346, ECO:0000269\|PubMed:178875, ECO:0007744\|PDB:1A71, ECO:0007744\|PDB:1A72, ECO:0007744\|PDB:1ADB, ECO:0007744\|PDB:1ADC, ECO:0007744\|PDB:1ADF, ECO:0007744\|PDB:1ADG, ECO:0007744\|PDB:1AXE, ECO:0007744\|PDB:1AXG, ECO:0007744\|PDB:1BTO, ECO:0007744\|PDB:1HET, ECO:0007744\|PDB:1HLD, ECO:0007744\|PDB:1JU9, ECO:0007744\|PDB:1LDE, ECO:0007744\|PDB:1LDY, ECO:0007744\|PDB:1MG0, ECO:0007744\|PDB:1MGO, ECO:0007744\|PDB:1N8K, ECO:0007744\|PDB:1N92, ECO:0007744\|PDB:1P1R, ECO:0007744\|PDB:1QLH, ECO:0007744\|PDB:1QLJ, ECO:0007744\|PDB:1QV6, ECO:0007744\|PDB:1QV7, ECO:0007744\|PDB:1YE3, ECO:0007744\|PDB:2JHG, ECO:0007744\|PDB:2OHX, ECO:0007744\|PDB:2OXI, ECO:0007744\|PDB:3BTO, ECO:0007744\|PDB:3OQ6, ECO:0007744\|PDB:4DWV, ECO:0007744\|PDB:4DXH, ECO:0007744\|PDB:4NFH, ECO:0007744\|PDB:4NFS, ECO:0007744\|PDB:4NG5, ECO:0007744\|PDB:4XD2, ECO:0007744\|PDB:5ADH, ECO:0007744\|PDB:6ADH, ECO:0007744\|PDB:7ADH, ECO:0007744\|PDB:8ADH
	source	Swiss-Prot : SWS_FT_FI3

71)	chain	A
	residue	200
	type	BINDING
	sequence	L
	description	BINDING => ECO:0000269\|PubMed:15299346, ECO:0007744\|PDB:1ADB, ECO:0007744\|PDB:1AXE, ECO:0007744\|PDB:1BTO, ECO:0007744\|PDB:1HET, ECO:0007744\|PDB:1HEU, ECO:0007744\|PDB:1HF3, ECO:0007744\|PDB:1HLD, ECO:0007744\|PDB:1JU9, ECO:0007744\|PDB:1LDE, ECO:0007744\|PDB:1LDY, ECO:0007744\|PDB:1MG0, ECO:0007744\|PDB:1MGO, ECO:0007744\|PDB:1N8K, ECO:0007744\|PDB:1N92, ECO:0007744\|PDB:1P1R, ECO:0007744\|PDB:1QV6, ECO:0007744\|PDB:1QV7, ECO:0007744\|PDB:2JHF, ECO:0007744\|PDB:2JHG, ECO:0007744\|PDB:2OHX, ECO:0007744\|PDB:2OXI, ECO:0007744\|PDB:3BTO, ECO:0007744\|PDB:3OQ6, ECO:0007744\|PDB:4DWV, ECO:0007744\|PDB:4DXH, ECO:0007744\|PDB:4NFH, ECO:0007744\|PDB:4XD2, ECO:0007744\|PDB:6ADH
	source	Swiss-Prot : SWS_FT_FI5

72)	chain	A
	residue	224
	type	BINDING
	sequence	I
	description	BINDING => ECO:0000269\|PubMed:15299346, ECO:0007744\|PDB:1A71, ECO:0007744\|PDB:1ADB, ECO:0007744\|PDB:1AXE, ECO:0007744\|PDB:1AXG, ECO:0007744\|PDB:1BTO, ECO:0007744\|PDB:1HET, ECO:0007744\|PDB:1HEU, ECO:0007744\|PDB:1HF3, ECO:0007744\|PDB:1HLD, ECO:0007744\|PDB:1JU9, ECO:0007744\|PDB:1LDE, ECO:0007744\|PDB:1LDY, ECO:0007744\|PDB:1MG0, ECO:0007744\|PDB:1MGO, ECO:0007744\|PDB:1N8K, ECO:0007744\|PDB:1N92, ECO:0007744\|PDB:1P1R, ECO:0007744\|PDB:1QLH, ECO:0007744\|PDB:1QV6, ECO:0007744\|PDB:1QV7, ECO:0007744\|PDB:2JHF, ECO:0007744\|PDB:2JHG, ECO:0007744\|PDB:2OHX, ECO:0007744\|PDB:2OXI, ECO:0007744\|PDB:3BTO, ECO:0007744\|PDB:3OQ6, ECO:0007744\|PDB:4DWV, ECO:0007744\|PDB:4DXH, ECO:0007744\|PDB:4NFH, ECO:0007744\|PDB:4NFS, ECO:0007744\|PDB:4NG5, ECO:0007744\|PDB:4XD2, ECO:0007744\|PDB:5ADH, ECO:0007744\|PDB:6ADH
	source	Swiss-Prot : SWS_FT_FI6

73)	chain	A
	residue	2
	type	MOD_RES
	sequence	T
	description	N-acetylserine => ECO:0000269\|PubMed:5466062
	source	Swiss-Prot : SWS_FT_FI9

74)	chain	A
	residue	66-80
	type	prosite
	sequence	GHEAAGIVESIGEGV
	description	ADH_ZINC Zinc-containing alcohol dehydrogenases signature. GHEaAGIvesiGegV
	source	prosite : PS00059

75)	chain	A
	residue	49
	type	BINDING
	sequence	D
	description	BINDING => ECO:0000250\|UniProtKB:P06525
	source	Swiss-Prot : SWS_FT_FI2

76)	chain	A
	residue	293
	type	BINDING
	sequence	G
	description	BINDING => ECO:0000250\|UniProtKB:P06525
	source	Swiss-Prot : SWS_FT_FI2

77)	chain	A
	residue	320
	type	BINDING
	sequence	G
	description	BINDING => ECO:0000250\|UniProtKB:P06525
	source	Swiss-Prot : SWS_FT_FI2

78)	chain	A
	residue	175
	type	BINDING
	sequence	G
	description	BINDING => ECO:0000269\|PubMed:15299346, ECO:0007744\|PDB:1A71, ECO:0007744\|PDB:1A72, ECO:0007744\|PDB:1ADB, ECO:0007744\|PDB:1ADC, ECO:0007744\|PDB:1ADF, ECO:0007744\|PDB:1ADG, ECO:0007744\|PDB:1AXE, ECO:0007744\|PDB:1AXG, ECO:0007744\|PDB:1BTO, ECO:0007744\|PDB:1HET, ECO:0007744\|PDB:1HLD, ECO:0007744\|PDB:1JU9, ECO:0007744\|PDB:1LDE, ECO:0007744\|PDB:1LDY, ECO:0007744\|PDB:1MG0, ECO:0007744\|PDB:1MGO, ECO:0007744\|PDB:1N8K, ECO:0007744\|PDB:1N92, ECO:0007744\|PDB:1P1R, ECO:0007744\|PDB:1QLH, ECO:0007744\|PDB:1QLJ, ECO:0007744\|PDB:1QV6, ECO:0007744\|PDB:1QV7, ECO:0007744\|PDB:1YE3, ECO:0007744\|PDB:2JHG, ECO:0007744\|PDB:2OHX, ECO:0007744\|PDB:3BTO, ECO:0007744\|PDB:3OQ6, ECO:0007744\|PDB:4DWV, ECO:0007744\|PDB:4DXH, ECO:0007744\|PDB:4NFH, ECO:0007744\|PDB:4NFS, ECO:0007744\|PDB:4NG5, ECO:0007744\|PDB:4XD2, ECO:0007744\|PDB:5ADH, ECO:0007744\|PDB:6ADH, ECO:0007744\|PDB:7ADH, ECO:0007744\|PDB:8ADH
	source	Swiss-Prot : SWS_FT_FI4

79)	chain	A
	residue	370
	type	BINDING
	sequence	T
	description	BINDING => ECO:0000269\|PubMed:15299346, ECO:0007744\|PDB:1A71, ECO:0007744\|PDB:1ADB, ECO:0007744\|PDB:1AXE, ECO:0007744\|PDB:1AXG, ECO:0007744\|PDB:1BTO, ECO:0007744\|PDB:1HET, ECO:0007744\|PDB:1HEU, ECO:0007744\|PDB:1HF3, ECO:0007744\|PDB:1HLD, ECO:0007744\|PDB:1LDE, ECO:0007744\|PDB:1LDY, ECO:0007744\|PDB:1MG0, ECO:0007744\|PDB:1MGO, ECO:0007744\|PDB:1N8K, ECO:0007744\|PDB:1N92, ECO:0007744\|PDB:1P1R, ECO:0007744\|PDB:1QV6, ECO:0007744\|PDB:1QV7, ECO:0007744\|PDB:2JHF, ECO:0007744\|PDB:2JHG, ECO:0007744\|PDB:2OHX, ECO:0007744\|PDB:2OXI, ECO:0007744\|PDB:3BTO, ECO:0007744\|PDB:3OQ6, ECO:0007744\|PDB:4DWV, ECO:0007744\|PDB:4DXH, ECO:0007744\|PDB:4NFH, ECO:0007744\|PDB:4NFS, ECO:0007744\|PDB:4NG5, ECO:0007744\|PDB:4XD2, ECO:0007744\|PDB:6ADH
	source	Swiss-Prot : SWS_FT_FI8