eF-site ID 1acj-A PDB Code 1acj Chain A click to enlarge Title QUATERNARY LIGAND BINDING TO AROMATIC RESIDUES IN THE ACTIVE-SITE GORGE OF ACETYLCHOLINESTERASE Classification HYDROLASE(CARBOXYLIC ESTERASE) Compound ACETYLCHOLINESTERASE Source Tetronarce californica (Pacific electric ray) (Torpedo californica) (ACES_TORCA) Sequence A:  SELLVNTKSGKVMGTRVPVLSSHISAFLGIPFAEPPVGNM RFRRPEPKKPWSGVWNASTYPNNCQQYVDEQFPGFSGSEM WNPNREMSEDCLYLNIWVPSPRPKSTTVMVWIYGGGFYSG SSTLDVYNGKYLAYTEEVVLVSLSYRVGAFGFLALHGSQE APGNVGLLDQRMALQWVHDNIQFFGGDPKTVTIFGESAGG ASVGMHILSPGSRDLFRRAILQSGSPNCPWASVSVAEGRR RAVELGRNLNCNLNSDEELIHCLREKKPQELIDVEWNVLP FDSIFRFSFVPVIDGEFFPTSLESMLNSGNFKKTQILLGV NKDEGSFFLLYGAPGFSKDSESKISREDFMSGVKLSVPHA NDLGLDAVTLQYTDWMDDNNGIKNRDGLDDIVGDHNVICP LMHFVNKYTKFGNGTYLYFFNHRASNLVWPEWMGVIHGYE IEFVFGLPLVKELNYTAEEEALSRRIMHYWATFAKTGNPN EPSKWPLFTTKEQKFIDLNTEPMKVHQRLRVQMCVFWNQF LPKLLNAT Description Functional site 1) chain A residue 200 type sequence S description source : THA 2) chain A residue 440 type sequence H description source : THA 3) chain A residue 327 type sequence E description source : THA 4) chain A residue 84 type sequence W description BINDING SITE FOR RESIDUE THA A 999 source : AC1 5) chain A residue 118 type sequence G description BINDING SITE FOR RESIDUE THA A 999 source : AC1 6) chain A residue 199 type sequence E description BINDING SITE FOR RESIDUE THA A 999 source : AC1 7) chain A residue 330 type sequence F description BINDING SITE FOR RESIDUE THA A 999 source : AC1 8) chain A residue 432 type sequence W description BINDING SITE FOR RESIDUE THA A 999 source : AC1 9) chain A residue 440 type sequence H description BINDING SITE FOR RESIDUE THA A 999 source : AC1 10) chain A residue 441 type sequence G description BINDING SITE FOR RESIDUE THA A 999 source : AC1 11) chain A residue 187-202 type prosite sequence FGGDPKTVTIFGESAG description CARBOXYLESTERASE_B_1 Carboxylesterases type-B serine active site. FGGdpktVtIfGeSAG source prosite : PS00122 12) chain A residue 92-102 type prosite sequence EDCLYLNIWVP description CARBOXYLESTERASE_B_2 Carboxylesterases type-B signature 2. EDCLYLNIWvP source prosite : PS00941 13) chain A residue 200 type ACT_SITE sequence S description Acyl-ester intermediate source Swiss-Prot : SWS_FT_FI1 14) chain A residue 327 type ACT_SITE sequence E description Charge relay system source Swiss-Prot : SWS_FT_FI2 15) chain A residue 440 type ACT_SITE sequence H description Charge relay system source Swiss-Prot : SWS_FT_FI2 16) chain A residue 59 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10368299, ECO:0000269|PubMed:16763558 source Swiss-Prot : SWS_FT_FI3 17) chain A residue 416 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10368299, ECO:0000269|PubMed:16763558, ECO:0000269|PubMed:1678899 source Swiss-Prot : SWS_FT_FI4 18) chain A residue 457 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10368299 source Swiss-Prot : SWS_FT_FI5 19) chain A residue 533 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10368299 source Swiss-Prot : SWS_FT_FI5

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