eF-site ID 1a9x-G PDB Code 1a9x Chain G click to enlarge Title CARBAMOYL PHOSPHATE SYNTHETASE: CAUGHT IN THE ACT OF GLUTAMINE HYDROLYSIS Classification AMIDOTRANSFERASE Compound CARBAMOYL PHOSPHATE SYNTHETASE (LARGE CHAIN) Source Escherichia coli (strain K12) (CARA_ECOLI) Sequence G:  MPKRTDIKSILILGAGPIVIGQACEFDYSGAQACKALREE GYRVINVNSNPATIMTDPEMADATYIEPIHWEVVRKIIEK ERPDAVLPTMGGQTALNCALELERQGVLEEFGVTMIGATA DAIDKAEDRRRFDVAMKKIGLETARSGIAHTMEEALAVAA DVGFPCIIRPSFTMGGSGGGIAYNREEFEEICARGLDLSP TKELLIDESLIGWKEYEMEVVRDKNDNCIIVCSIENFDAM GIHTGDSITVAPAQTLTDKEYQIMRNASMAVLREIGVETG GSNVQFAVNPKNGRLIVIEMNPRVSRSSALASKATGFPIA KVAAKLAVGYTLDELMNDITGGRTPASFEPSIDYVVTKIP RFNFEKFAGANDRLTTQMKSVGEVMAIGRTQQESLQKALR GLEVGATGFDPKVSLDDPEALTKIRRELKDAGADRIWYIA DAFRAGLSVDGVFNLTNIDRWFLVQIEELVRLEEKVAEVG ITGLNADFLRQLKRKGFADARLAKLAGVREAEIRKLRDQY DLHPVYKRVDTCAAEFATDTAYMYSTYEEECEANPSTDRE KIMVLGGGPNRIGQGIEFDYCCVHASLALREDGYETIMVN CNPETVSTDYDTSDRLYFEPVTLEDVLEIVRIEKPKGVIV QYGGQTPLKLARALEAAGVPVIGTSPDAIDRAEDRERFQH AVERLKLKQPANATVTAIEMAVEKAKEIGYPLVVRAAMEI VYDEADLRRYFQTAVLLDHFLDDAVEVDVDAICDGEMVLI GGIMEHIEQAGVHSGDSACSLPAYTLSQEIQDVMRQQVQK LAFELQVRGLMNVQFAVKNNEVYLIEVNPRAARTVPFVSK ATGVPLAKVAARVMAGKSLAEQGVTKEVIPPYYSVKEVVL PFNKFPGVDPLLGPEMRSTGEVMGVGRTFAEAFAKAQLGS NSTMKKHGRALLSVREGDKERVVDLAAKLLKQGFELDATH GTAIVLGEAGINPRLVNKVHEGRPHIQDRIKNGEYTYIIN TTSGRRAIEDSRVIRRSALQYKVHYDTTLNGGFATAMALN ADATEKVISVQEMHAQIK Description Functional site 1) chain G residue 6129 type sequence R description ADP BINDING SITE. source : AD7 2) chain G residue 6169 type sequence R description ADP BINDING SITE. source : AD7 3) chain G residue 6176 type sequence G description ADP BINDING SITE. source : AD7 4) chain G residue 6208 type sequence E description ADP BINDING SITE. source : AD7 5) chain G residue 6210 type sequence L description ADP BINDING SITE. source : AD7 6) chain G residue 6215 type sequence E description ADP BINDING SITE. source : AD7 7) chain G residue 6241 type sequence G description ADP BINDING SITE. source : AD7 8) chain G residue 6242 type sequence I description ADP BINDING SITE. source : AD7 9) chain G residue 6243 type sequence H description ADP BINDING SITE. source : AD7 10) chain G residue 6285 type sequence Q description ADP BINDING SITE. source : AD7 11) chain G residue 6299 type sequence E description ADP BINDING SITE. source : AD7 12) chain G residue 6715 type sequence R description ADP BINDING SITE. source : AD8 13) chain G residue 6754 type sequence H description ADP BINDING SITE. source : AD8 14) chain G residue 6756 type sequence L description ADP BINDING SITE. source : AD8 15) chain G residue 6761 type sequence E description ADP BINDING SITE. source : AD8 16) chain G residue 6786 type sequence G description ADP BINDING SITE. source : AD8 17) chain G residue 6787 type sequence V description ADP BINDING SITE. source : AD8 18) chain G residue 6788 type sequence H description ADP BINDING SITE. source : AD8 19) chain G residue 6841 type sequence E description ADP BINDING SITE. source : AD8 20) chain G residue 6791 type sequence D description ORNITHINE BINDING SITE. source : OR4 21) chain G residue 6783 type sequence E description ORNITHINE BINDING SITE. source : OR4 22) chain G residue 6892 type sequence E description ORNITHINE BINDING SITE. source : OR4 23) chain G residue 7040 type sequence Y description ORNITHINE BINDING SITE. source : OR4 24) chain G residue 7042 type sequence T description ORNITHINE BINDING SITE. source : OR4 25) chain G residue 6174 type sequence M description BINDING SITE FOR RESIDUE MN G 7901 source : AC1 26) chain G residue 6299 type sequence E description BINDING SITE FOR RESIDUE MN G 7901 source : AC1 27) chain G residue 6301 type sequence N description BINDING SITE FOR RESIDUE MN G 7901 source : AC1 28) chain G residue 6285 type sequence Q description BINDING SITE FOR RESIDUE MN G 7902 source : AC2 29) chain G residue 6299 type sequence E description BINDING SITE FOR RESIDUE MN G 7902 source : AC2 30) chain G residue 6215 type sequence E description BINDING SITE FOR RESIDUE K G 7903 source : AC3 31) chain G residue 6236 type sequence N description BINDING SITE FOR RESIDUE K G 7903 source : AC3 32) chain G residue 6238 type sequence D description BINDING SITE FOR RESIDUE K G 7903 source : AC3 33) chain G residue 6239 type sequence A description BINDING SITE FOR RESIDUE K G 7903 source : AC3 34) chain G residue 6242 type sequence I description BINDING SITE FOR RESIDUE K G 7903 source : AC3 35) chain G residue 6247 type sequence S description BINDING SITE FOR RESIDUE K G 7903 source : AC3 36) chain G residue 6126 type sequence A description BINDING SITE FOR RESIDUE K G 7904 source : AC4 37) chain G residue 6127 type sequence E description BINDING SITE FOR RESIDUE K G 7904 source : AC4 38) chain G residue 6299 type sequence E description BINDING SITE FOR RESIDUE K G 7904 source : AC4 39) chain G residue 6300 type sequence M description BINDING SITE FOR RESIDUE K G 7904 source : AC4 40) chain G residue 6301 type sequence N description BINDING SITE FOR RESIDUE K G 7904 source : AC4 41) chain G residue 6174 type sequence M description BINDING SITE FOR RESIDUE PO4 G 7906 source : AC5 42) chain G residue 6175 type sequence G description BINDING SITE FOR RESIDUE PO4 G 7906 source : AC5 43) chain G residue 6243 type sequence H description BINDING SITE FOR RESIDUE PO4 G 7906 source : AC5 44) chain G residue 6285 type sequence Q description BINDING SITE FOR RESIDUE PO4 G 7906 source : AC5 45) chain G residue 6299 type sequence E description BINDING SITE FOR RESIDUE PO4 G 7906 source : AC5 46) chain G residue 6301 type sequence N description BINDING SITE FOR RESIDUE PO4 G 7906 source : AC5 47) chain G residue 6303 type sequence R description BINDING SITE FOR RESIDUE PO4 G 7906 source : AC5 48) chain G residue 6306 type sequence R description BINDING SITE FOR RESIDUE PO4 G 7906 source : AC5 49) chain G residue 6829 type sequence Q description BINDING SITE FOR RESIDUE MN G 7911 source : AC6 50) chain G residue 6841 type sequence E description BINDING SITE FOR RESIDUE MN G 7911 source : AC6 51) chain G residue 6841 type sequence E description BINDING SITE FOR RESIDUE K G 7912 source : AC7 52) chain G residue 6843 type sequence N description BINDING SITE FOR RESIDUE K G 7912 source : AC7 53) chain G residue 6761 type sequence E description BINDING SITE FOR RESIDUE K G 7913 source : AC8 54) chain G residue 6781 type sequence H description BINDING SITE FOR RESIDUE K G 7913 source : AC8 55) chain G residue 6783 type sequence E description BINDING SITE FOR RESIDUE K G 7913 source : AC8 56) chain G residue 6784 type sequence Q description BINDING SITE FOR RESIDUE K G 7913 source : AC8 57) chain G residue 6787 type sequence V description BINDING SITE FOR RESIDUE K G 7913 source : AC8 58) chain G residue 6792 type sequence S description BINDING SITE FOR RESIDUE K G 7913 source : AC8 59) chain G residue 6093 type sequence Q description BINDING SITE FOR RESIDUE CL G 7930 source : AC9 60) chain G residue 6173 type sequence T description BINDING SITE FOR RESIDUE CL G 7930 source : AC9 61) chain G residue 6174 type sequence M description BINDING SITE FOR RESIDUE CL G 7930 source : AC9 62) chain G residue 6289 type sequence N description BINDING SITE FOR RESIDUE CL G 7931 source : BC1 63) chain G residue 6292 type sequence N description BINDING SITE FOR RESIDUE CL G 7931 source : BC1 64) chain G residue 6294 type sequence R description BINDING SITE FOR RESIDUE CL G 7931 source : BC1 65) chain G residue 6370 type sequence A description BINDING SITE FOR RESIDUE CL G 7932 source : BC2 66) chain G residue 6371 type sequence N description BINDING SITE FOR RESIDUE CL G 7932 source : BC2 67) chain G residue 6900 type sequence F description BINDING SITE FOR RESIDUE CL G 7932 source : BC2 68) chain G residue 6901 type sequence P description BINDING SITE FOR RESIDUE CL G 7932 source : BC2 69) chain G residue 6902 type sequence G description BINDING SITE FOR RESIDUE CL G 7932 source : BC2 70) chain G residue 6845 type sequence R description BINDING SITE FOR RESIDUE CL G 7934 source : BC4 71) chain G residue 6847 type sequence A description BINDING SITE FOR RESIDUE CL G 7934 source : BC4 72) chain G residue 6848 type sequence R description BINDING SITE FOR RESIDUE CL G 7934 source : BC4 73) chain G residue 6071 type sequence W description BINDING SITE FOR RESIDUE CL G 7935 source : BC5 74) chain G residue 6475 type sequence K description BINDING SITE FOR RESIDUE CL G 7936 source : BC6 75) chain G residue 6485 type sequence N description BINDING SITE FOR RESIDUE CL G 7936 source : BC6 76) chain G residue 6084 type sequence D description BINDING SITE FOR RESIDUE K G 7940 source : BC7 77) chain G residue 6112 type sequence G description BINDING SITE FOR RESIDUE K G 7940 source : BC7 78) chain G residue 6114 type sequence T description BINDING SITE FOR RESIDUE K G 7940 source : BC7 79) chain G residue 6217 type sequence E description BINDING SITE FOR RESIDUE K G 7942 source : BC9 80) chain G residue 6244 type sequence T description BINDING SITE FOR RESIDUE K G 7942 source : BC9 81) chain G residue 6283 type sequence N description BINDING SITE FOR RESIDUE K G 7942 source : BC9 82) chain G residue 6285 type sequence Q description BINDING SITE FOR RESIDUE K G 7942 source : BC9 83) chain G residue 6307 type sequence S description BINDING SITE FOR RESIDUE K G 7942 source : BC9 84) chain G residue 6143 type sequence T description BINDING SITE FOR RESIDUE K G 7943 source : CC1 85) chain G residue 6144 type sequence A description BINDING SITE FOR RESIDUE K G 7943 source : CC1 86) chain G residue 6475 type sequence K description BINDING SITE FOR RESIDUE PO4 G 7980 source : HC2 87) chain G residue 6491 type sequence Q description BINDING SITE FOR RESIDUE PO4 G 7980 source : HC2 88) chain G residue 6798 type sequence A description BINDING SITE FOR RESIDUE PO4 G 7981 source : HC3 89) chain G residue 6799 type sequence Y description BINDING SITE FOR RESIDUE PO4 G 7981 source : HC3 90) chain G residue 6800 type sequence T description BINDING SITE FOR RESIDUE PO4 G 7981 source : HC3 91) chain G residue 6801 type sequence L description BINDING SITE FOR RESIDUE PO4 G 7981 source : HC3 92) chain G residue 6592 type sequence D description BINDING SITE FOR RESIDUE PO4 G 7982 source : HC4 93) chain G residue 6593 type sequence G description BINDING SITE FOR RESIDUE PO4 G 7982 source : HC4 94) chain G residue 6129 type sequence R description BINDING SITE FOR RESIDUE ADP G 7900 source : JC6 95) chain G residue 6167 type sequence I description BINDING SITE FOR RESIDUE ADP G 7900 source : JC6 96) chain G residue 6169 type sequence R description BINDING SITE FOR RESIDUE ADP G 7900 source : JC6 97) chain G residue 6173 type sequence T description BINDING SITE FOR RESIDUE ADP G 7900 source : JC6 98) chain G residue 6174 type sequence M description BINDING SITE FOR RESIDUE ADP G 7900 source : JC6 99) chain G residue 6175 type sequence G description BINDING SITE FOR RESIDUE ADP G 7900 source : JC6 100) chain G residue 6176 type sequence G description BINDING SITE FOR RESIDUE ADP G 7900 source : JC6 101) chain G residue 6208 type sequence E description BINDING SITE FOR RESIDUE ADP G 7900 source : JC6 102) chain G residue 6210 type sequence L description BINDING SITE FOR RESIDUE ADP G 7900 source : JC6 103) chain G residue 6215 type sequence E description BINDING SITE FOR RESIDUE ADP G 7900 source : JC6 104) chain G residue 6240 type sequence M description BINDING SITE FOR RESIDUE ADP G 7900 source : JC6 105) chain G residue 6241 type sequence G description BINDING SITE FOR RESIDUE ADP G 7900 source : JC6 106) chain G residue 6242 type sequence I description BINDING SITE FOR RESIDUE ADP G 7900 source : JC6 107) chain G residue 6243 type sequence H description BINDING SITE FOR RESIDUE ADP G 7900 source : JC6 108) chain G residue 6244 type sequence T description BINDING SITE FOR RESIDUE ADP G 7900 source : JC6 109) chain G residue 6285 type sequence Q description BINDING SITE FOR RESIDUE ADP G 7900 source : JC6 110) chain G residue 6299 type sequence E description BINDING SITE FOR RESIDUE ADP G 7900 source : JC6 111) chain G residue 6376 type sequence T description BINDING SITE FOR RESIDUE ADP G 7900 source : JC6 112) chain G residue 6690 type sequence P description BINDING SITE FOR RESIDUE ADP G 7910 source : JC7 113) chain G residue 6715 type sequence R description BINDING SITE FOR RESIDUE ADP G 7910 source : JC7 114) chain G residue 6725 type sequence M description BINDING SITE FOR RESIDUE ADP G 7910 source : JC7 115) chain G residue 6754 type sequence H description BINDING SITE FOR RESIDUE ADP G 7910 source : JC7 116) chain G residue 6755 type sequence F description BINDING SITE FOR RESIDUE ADP G 7910 source : JC7 117) chain G residue 6756 type sequence L description BINDING SITE FOR RESIDUE ADP G 7910 source : JC7 118) chain G residue 6761 type sequence E description BINDING SITE FOR RESIDUE ADP G 7910 source : JC7 119) chain G residue 6785 type sequence A description BINDING SITE FOR RESIDUE ADP G 7910 source : JC7 120) chain G residue 6786 type sequence G description BINDING SITE FOR RESIDUE ADP G 7910 source : JC7 121) chain G residue 6787 type sequence V description BINDING SITE FOR RESIDUE ADP G 7910 source : JC7 122) chain G residue 6788 type sequence H description BINDING SITE FOR RESIDUE ADP G 7910 source : JC7 123) chain G residue 6789 type sequence S description BINDING SITE FOR RESIDUE ADP G 7910 source : JC7 124) chain G residue 6829 type sequence Q description BINDING SITE FOR RESIDUE ADP G 7910 source : JC7 125) chain G residue 6841 type sequence E description BINDING SITE FOR RESIDUE ADP G 7910 source : JC7 126) chain G residue 6783 type sequence E description BINDING SITE FOR RESIDUE ORN G 7920 source : JC8 127) chain G residue 6791 type sequence D description BINDING SITE FOR RESIDUE ORN G 7920 source : JC8 128) chain G residue 6892 type sequence E description BINDING SITE FOR RESIDUE ORN G 7920 source : JC8 129) chain G residue 6893 type sequence V description BINDING SITE FOR RESIDUE ORN G 7920 source : JC8 130) chain G residue 6907 type sequence L description BINDING SITE FOR RESIDUE ORN G 7920 source : JC8 131) chain G residue 7040 type sequence Y description BINDING SITE FOR RESIDUE ORN G 7920 source : JC8 132) chain G residue 7041 type sequence D description BINDING SITE FOR RESIDUE ORN G 7920 source : JC8 133) chain G residue 7042 type sequence T description BINDING SITE FOR RESIDUE ORN G 7920 source : JC8 134) chain G residue 6022 type sequence Q description BINDING SITE FOR RESIDUE NET G 7950 source : JC9 135) chain G residue 6093 type sequence Q description BINDING SITE FOR RESIDUE NET G 7950 source : JC9 136) chain G residue 6094 type sequence T description BINDING SITE FOR RESIDUE NET G 7950 source : JC9 137) chain G residue 6097 type sequence N description BINDING SITE FOR RESIDUE NET G 7950 source : JC9 138) chain G residue 6304 type catalytic sequence V description 435 source MCSA : MCSA4 139) chain G residue 6716 type catalytic sequence A description 435 source MCSA : MCSA4 140) chain G residue 6762 type catalytic sequence V description 435 source MCSA : MCSA4 141) chain G residue 6830 type catalytic sequence F description 435 source MCSA : MCSA4 142) chain G residue 6842 type catalytic sequence V description 435 source MCSA : MCSA4 143) chain G residue 6844 type catalytic sequence P description 435 source MCSA : MCSA4 144) chain G residue 6849 type catalytic sequence T description 435 source MCSA : MCSA4 145) chain G residue 6216 type catalytic sequence Y description 435 source MCSA : MCSA4 146) chain G residue 6244 type catalytic sequence T description 435 source MCSA : MCSA4 147) chain G residue 6284 type catalytic sequence V description 435 source MCSA : MCSA4 148) chain G residue 6286 type catalytic sequence F description 435 source MCSA : MCSA4 149) chain G residue 6300 type catalytic sequence M description 435 source MCSA : MCSA4 150) chain G residue 6302 type catalytic sequence P description 435 source MCSA : MCSA4 151) chain G residue 6130 type ACT_SITE sequence R description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 152) chain G residue 6170 type ACT_SITE sequence P description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 153) chain G residue 6176 type ACT_SITE sequence G description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 154) chain G residue 6177 type ACT_SITE sequence S description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 155) chain G residue 6209 type ACT_SITE sequence S description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 156) chain G residue 6211 type ACT_SITE sequence I description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 157) chain G residue 6216 type ACT_SITE sequence Y description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 158) chain G residue 6242 type ACT_SITE sequence I description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 159) chain G residue 6243 type ACT_SITE sequence H description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 160) chain G residue 6244 type ACT_SITE sequence T description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 161) chain G residue 6716 type ACT_SITE sequence A description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 162) chain G residue 6755 type ACT_SITE sequence F description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 163) chain G residue 6757 type ACT_SITE sequence D description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 164) chain G residue 6762 type ACT_SITE sequence V description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 165) chain G residue 6787 type ACT_SITE sequence V description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 166) chain G residue 6788 type ACT_SITE sequence H description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 167) chain G residue 6789 type ACT_SITE sequence S description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 168) chain G residue 6790 type ACT_SITE sequence G description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 169) chain G residue 6830 type BINDING sequence F description BINDING => ECO:0000255|HAMAP-Rule:MF_01210, ECO:0000269|PubMed:10428826, ECO:0000269|PubMed:9636022, ECO:0007744|PDB:1CE8 source Swiss-Prot : SWS_FT_FI4 170) chain G residue 6842 type BINDING sequence V description BINDING => ECO:0000255|HAMAP-Rule:MF_01210, ECO:0000269|PubMed:10029528, ECO:0000269|PubMed:10089390, ECO:0000269|PubMed:10428826, ECO:0000269|PubMed:9636022, ECO:0007744|PDB:1CE8 source Swiss-Prot : SWS_FT_FI5 171) chain G residue 6844 type BINDING sequence P description BINDING => ECO:0000255|HAMAP-Rule:MF_01210, ECO:0000269|PubMed:10029528, ECO:0000269|PubMed:10089390 source Swiss-Prot : SWS_FT_FI6

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