eF-site ID 1a9x-C PDB Code 1a9x Chain C click to enlarge Title CARBAMOYL PHOSPHATE SYNTHETASE: CAUGHT IN THE ACT OF GLUTAMINE HYDROLYSIS Classification AMIDOTRANSFERASE Compound CARBAMOYL PHOSPHATE SYNTHETASE (LARGE CHAIN) Source Escherichia coli (strain K12) (CARA_ECOLI) Sequence C:  MPKRTDIKSILILGAGPIVIGQACEFDYSGAQACKALREE GYRVINVNSNPATIMTDPEMADATYIEPIHWEVVRKIIEK ERPDAVLPTMGGQTALNCALELERQGVLEEFGVTMIGATA DAIDKAEDRRRFDVAMKKIGLETARSGIAHTMEEALAVAA DVGFPCIIRPSFTMGGSGGGIAYNREEFEEICARGLDLSP TKELLIDESLIGWKEYEMEVVRDKNDNCIIVCSIENFDAM GIHTGDSITVAPAQTLTDKEYQIMRNASMAVLREIGVETG GSNVQFAVNPKNGRLIVIEMNPRVSRSSALASKATGFPIA KVAAKLAVGYTLDELMNDITGGRTPASFEPSIDYVVTKIP RFNFEKFAGANDRLTTQMKSVGEVMAIGRTQQESLQKALR GLEVGATGFDPKVSLDDPEALTKIRRELKDAGADRIWYIA DAFRAGLSVDGVFNLTNIDRWFLVQIEELVRLEEKVAEVG ITGLNADFLRQLKRKGFADARLAKLAGVREAEIRKLRDQY DLHPVYKRVDTCAAEFATDTAYMYSTYEEECEANPSTDRE KIMVLGGGPNRIGQGIEFDYCCVHASLALREDGYETIMVN CNPETVSTDYDTSDRLYFEPVTLEDVLEIVRIEKPKGVIV QYGGQTPLKLARALEAAGVPVIGTSPDAIDRAEDRERFQH AVERLKLKQPANATVTAIEMAVEKAKEIGYPLVVRAAMEI VYDEADLRRYFQTAVLLDHFLDDAVEVDVDAICDGEMVLI GGIMEHIEQAGVHSGDSACSLPAYTLSQEIQDVMRQQVQK LAFELQVRGLMNVQFAVKNNEVYLIEVNPRAARTVPFVSK ATGVPLAKVAARVMAGKSLAEQGVTKEVIPPYYSVKEVVL PFNKFPGVDPLLGPEMRSTGEVMGVGRTFAEAFAKAQLGS NSTMKKHGRALLSVREGDKERVVDLAAKLLKQGFELDATH GTAIVLGEAGINPRLVNKVHEGRPHIQDRIKNGEYTYIIN TTSGRRAIEDSRVIRRSALQYKVHYDTTLNGGFATAMALN ADATEKVISVQEMHAQIK Description Functional site 1) chain C residue 2129 type sequence R description ADP BINDING SITE. source : AD3 2) chain C residue 2169 type sequence R description ADP BINDING SITE. source : AD3 3) chain C residue 2176 type sequence G description ADP BINDING SITE. source : AD3 4) chain C residue 2208 type sequence E description ADP BINDING SITE. source : AD3 5) chain C residue 2210 type sequence L description ADP BINDING SITE. source : AD3 6) chain C residue 2215 type sequence E description ADP BINDING SITE. source : AD3 7) chain C residue 2241 type sequence G description ADP BINDING SITE. source : AD3 8) chain C residue 2242 type sequence I description ADP BINDING SITE. source : AD3 9) chain C residue 2243 type sequence H description ADP BINDING SITE. source : AD3 10) chain C residue 2285 type sequence Q description ADP BINDING SITE. source : AD3 11) chain C residue 2299 type sequence E description ADP BINDING SITE. source : AD3 12) chain C residue 2715 type sequence R description ADP BINDING SITE. source : AD4 13) chain C residue 2754 type sequence H description ADP BINDING SITE. source : AD4 14) chain C residue 2756 type sequence L description ADP BINDING SITE. source : AD4 15) chain C residue 2761 type sequence E description ADP BINDING SITE. source : AD4 16) chain C residue 2786 type sequence G description ADP BINDING SITE. source : AD4 17) chain C residue 2787 type sequence V description ADP BINDING SITE. source : AD4 18) chain C residue 2788 type sequence H description ADP BINDING SITE. source : AD4 19) chain C residue 2841 type sequence E description ADP BINDING SITE. source : AD4 20) chain C residue 2791 type sequence D description ORNITHINE BINDING SITE. source : OR2 21) chain C residue 2783 type sequence E description ORNITHINE BINDING SITE. source : OR2 22) chain C residue 2892 type sequence E description ORNITHINE BINDING SITE. source : OR2 23) chain C residue 3040 type sequence Y description ORNITHINE BINDING SITE. source : OR2 24) chain C residue 3042 type sequence T description ORNITHINE BINDING SITE. source : OR2 25) chain C residue 2299 type sequence E description BINDING SITE FOR RESIDUE MN C 3901 source : CC4 26) chain C residue 2301 type sequence N description BINDING SITE FOR RESIDUE MN C 3901 source : CC4 27) chain C residue 2285 type sequence Q description BINDING SITE FOR RESIDUE MN C 3902 source : CC5 28) chain C residue 2299 type sequence E description BINDING SITE FOR RESIDUE MN C 3902 source : CC5 29) chain C residue 2215 type sequence E description BINDING SITE FOR RESIDUE K C 3903 source : CC6 30) chain C residue 2236 type sequence N description BINDING SITE FOR RESIDUE K C 3903 source : CC6 31) chain C residue 2238 type sequence D description BINDING SITE FOR RESIDUE K C 3903 source : CC6 32) chain C residue 2239 type sequence A description BINDING SITE FOR RESIDUE K C 3903 source : CC6 33) chain C residue 2242 type sequence I description BINDING SITE FOR RESIDUE K C 3903 source : CC6 34) chain C residue 2247 type sequence S description BINDING SITE FOR RESIDUE K C 3903 source : CC6 35) chain C residue 2126 type sequence A description BINDING SITE FOR RESIDUE K C 3904 source : CC7 36) chain C residue 2127 type sequence E description BINDING SITE FOR RESIDUE K C 3904 source : CC7 37) chain C residue 2299 type sequence E description BINDING SITE FOR RESIDUE K C 3904 source : CC7 38) chain C residue 2300 type sequence M description BINDING SITE FOR RESIDUE K C 3904 source : CC7 39) chain C residue 2301 type sequence N description BINDING SITE FOR RESIDUE K C 3904 source : CC7 40) chain C residue 2174 type sequence M description BINDING SITE FOR RESIDUE PO4 C 3906 source : CC8 41) chain C residue 2175 type sequence G description BINDING SITE FOR RESIDUE PO4 C 3906 source : CC8 42) chain C residue 2243 type sequence H description BINDING SITE FOR RESIDUE PO4 C 3906 source : CC8 43) chain C residue 2285 type sequence Q description BINDING SITE FOR RESIDUE PO4 C 3906 source : CC8 44) chain C residue 2299 type sequence E description BINDING SITE FOR RESIDUE PO4 C 3906 source : CC8 45) chain C residue 2301 type sequence N description BINDING SITE FOR RESIDUE PO4 C 3906 source : CC8 46) chain C residue 2303 type sequence R description BINDING SITE FOR RESIDUE PO4 C 3906 source : CC8 47) chain C residue 2306 type sequence R description BINDING SITE FOR RESIDUE PO4 C 3906 source : CC8 48) chain C residue 2829 type sequence Q description BINDING SITE FOR RESIDUE MN C 3911 source : CC9 49) chain C residue 2841 type sequence E description BINDING SITE FOR RESIDUE MN C 3911 source : CC9 50) chain C residue 2841 type sequence E description BINDING SITE FOR RESIDUE K C 3912 source : DC1 51) chain C residue 2843 type sequence N description BINDING SITE FOR RESIDUE K C 3912 source : DC1 52) chain C residue 2761 type sequence E description BINDING SITE FOR RESIDUE K C 3913 source : DC2 53) chain C residue 2781 type sequence H description BINDING SITE FOR RESIDUE K C 3913 source : DC2 54) chain C residue 2783 type sequence E description BINDING SITE FOR RESIDUE K C 3913 source : DC2 55) chain C residue 2784 type sequence Q description BINDING SITE FOR RESIDUE K C 3913 source : DC2 56) chain C residue 2787 type sequence V description BINDING SITE FOR RESIDUE K C 3913 source : DC2 57) chain C residue 2792 type sequence S description BINDING SITE FOR RESIDUE K C 3913 source : DC2 58) chain C residue 2173 type sequence T description BINDING SITE FOR RESIDUE CL C 3930 source : DC3 59) chain C residue 2174 type sequence M description BINDING SITE FOR RESIDUE CL C 3930 source : DC3 60) chain C residue 2289 type sequence N description BINDING SITE FOR RESIDUE CL C 3931 source : DC4 61) chain C residue 2292 type sequence N description BINDING SITE FOR RESIDUE CL C 3931 source : DC4 62) chain C residue 2294 type sequence R description BINDING SITE FOR RESIDUE CL C 3931 source : DC4 63) chain C residue 2370 type sequence A description BINDING SITE FOR RESIDUE CL C 3932 source : DC5 64) chain C residue 2371 type sequence N description BINDING SITE FOR RESIDUE CL C 3932 source : DC5 65) chain C residue 2900 type sequence F description BINDING SITE FOR RESIDUE CL C 3932 source : DC5 66) chain C residue 2901 type sequence P description BINDING SITE FOR RESIDUE CL C 3932 source : DC5 67) chain C residue 2902 type sequence G description BINDING SITE FOR RESIDUE CL C 3932 source : DC5 68) chain C residue 2578 type sequence F description BINDING SITE FOR RESIDUE CL C 3934 source : DC7 69) chain C residue 2845 type sequence R description BINDING SITE FOR RESIDUE CL C 3934 source : DC7 70) chain C residue 2847 type sequence A description BINDING SITE FOR RESIDUE CL C 3934 source : DC7 71) chain C residue 2848 type sequence R description BINDING SITE FOR RESIDUE CL C 3934 source : DC7 72) chain C residue 2070 type sequence H description BINDING SITE FOR RESIDUE CL C 3935 source : DC8 73) chain C residue 2071 type sequence W description BINDING SITE FOR RESIDUE CL C 3935 source : DC8 74) chain C residue 2475 type sequence K description BINDING SITE FOR RESIDUE CL C 3936 source : DC9 75) chain C residue 2485 type sequence N description BINDING SITE FOR RESIDUE CL C 3936 source : DC9 76) chain C residue 2084 type sequence D description BINDING SITE FOR RESIDUE K C 3940 source : EC1 77) chain C residue 2112 type sequence G description BINDING SITE FOR RESIDUE K C 3940 source : EC1 78) chain C residue 2114 type sequence T description BINDING SITE FOR RESIDUE K C 3940 source : EC1 79) chain C residue 2217 type sequence E description BINDING SITE FOR RESIDUE K C 3942 source : EC3 80) chain C residue 2244 type sequence T description BINDING SITE FOR RESIDUE K C 3942 source : EC3 81) chain C residue 2283 type sequence N description BINDING SITE FOR RESIDUE K C 3942 source : EC3 82) chain C residue 2285 type sequence Q description BINDING SITE FOR RESIDUE K C 3942 source : EC3 83) chain C residue 2143 type sequence T description BINDING SITE FOR RESIDUE K C 3943 source : EC4 84) chain C residue 2144 type sequence A description BINDING SITE FOR RESIDUE K C 3943 source : EC4 85) chain C residue 2518 type sequence D description BINDING SITE FOR RESIDUE PO4 C 3980 source : EC5 86) chain C residue 2519 type sequence Q description BINDING SITE FOR RESIDUE PO4 C 3980 source : EC5 87) chain C residue 2592 type sequence D description BINDING SITE FOR RESIDUE PO4 C 3981 source : EC6 88) chain C residue 2593 type sequence G description BINDING SITE FOR RESIDUE PO4 C 3981 source : EC6 89) chain C residue 2801 type sequence L description BINDING SITE FOR RESIDUE PO4 C 3982 source : EC7 90) chain C residue 2129 type sequence R description BINDING SITE FOR RESIDUE ADP C 3900 source : KC1 91) chain C residue 2167 type sequence I description BINDING SITE FOR RESIDUE ADP C 3900 source : KC1 92) chain C residue 2169 type sequence R description BINDING SITE FOR RESIDUE ADP C 3900 source : KC1 93) chain C residue 2173 type sequence T description BINDING SITE FOR RESIDUE ADP C 3900 source : KC1 94) chain C residue 2174 type sequence M description BINDING SITE FOR RESIDUE ADP C 3900 source : KC1 95) chain C residue 2175 type sequence G description BINDING SITE FOR RESIDUE ADP C 3900 source : KC1 96) chain C residue 2176 type sequence G description BINDING SITE FOR RESIDUE ADP C 3900 source : KC1 97) chain C residue 2208 type sequence E description BINDING SITE FOR RESIDUE ADP C 3900 source : KC1 98) chain C residue 2209 type sequence S description BINDING SITE FOR RESIDUE ADP C 3900 source : KC1 99) chain C residue 2210 type sequence L description BINDING SITE FOR RESIDUE ADP C 3900 source : KC1 100) chain C residue 2211 type sequence I description BINDING SITE FOR RESIDUE ADP C 3900 source : KC1 101) chain C residue 2215 type sequence E description BINDING SITE FOR RESIDUE ADP C 3900 source : KC1 102) chain C residue 2240 type sequence M description BINDING SITE FOR RESIDUE ADP C 3900 source : KC1 103) chain C residue 2241 type sequence G description BINDING SITE FOR RESIDUE ADP C 3900 source : KC1 104) chain C residue 2242 type sequence I description BINDING SITE FOR RESIDUE ADP C 3900 source : KC1 105) chain C residue 2243 type sequence H description BINDING SITE FOR RESIDUE ADP C 3900 source : KC1 106) chain C residue 2244 type sequence T description BINDING SITE FOR RESIDUE ADP C 3900 source : KC1 107) chain C residue 2285 type sequence Q description BINDING SITE FOR RESIDUE ADP C 3900 source : KC1 108) chain C residue 2298 type sequence I description BINDING SITE FOR RESIDUE ADP C 3900 source : KC1 109) chain C residue 2299 type sequence E description BINDING SITE FOR RESIDUE ADP C 3900 source : KC1 110) chain C residue 2376 type sequence T description BINDING SITE FOR RESIDUE ADP C 3900 source : KC1 111) chain C residue 2690 type sequence P description BINDING SITE FOR RESIDUE ADP C 3910 source : KC2 112) chain C residue 2715 type sequence R description BINDING SITE FOR RESIDUE ADP C 3910 source : KC2 113) chain C residue 2725 type sequence M description BINDING SITE FOR RESIDUE ADP C 3910 source : KC2 114) chain C residue 2754 type sequence H description BINDING SITE FOR RESIDUE ADP C 3910 source : KC2 115) chain C residue 2755 type sequence F description BINDING SITE FOR RESIDUE ADP C 3910 source : KC2 116) chain C residue 2756 type sequence L description BINDING SITE FOR RESIDUE ADP C 3910 source : KC2 117) chain C residue 2761 type sequence E description BINDING SITE FOR RESIDUE ADP C 3910 source : KC2 118) chain C residue 2785 type sequence A description BINDING SITE FOR RESIDUE ADP C 3910 source : KC2 119) chain C residue 2786 type sequence G description BINDING SITE FOR RESIDUE ADP C 3910 source : KC2 120) chain C residue 2787 type sequence V description BINDING SITE FOR RESIDUE ADP C 3910 source : KC2 121) chain C residue 2788 type sequence H description BINDING SITE FOR RESIDUE ADP C 3910 source : KC2 122) chain C residue 2789 type sequence S description BINDING SITE FOR RESIDUE ADP C 3910 source : KC2 123) chain C residue 2829 type sequence Q description BINDING SITE FOR RESIDUE ADP C 3910 source : KC2 124) chain C residue 2841 type sequence E description BINDING SITE FOR RESIDUE ADP C 3910 source : KC2 125) chain C residue 2783 type sequence E description BINDING SITE FOR RESIDUE ORN C 3920 source : KC3 126) chain C residue 2791 type sequence D description BINDING SITE FOR RESIDUE ORN C 3920 source : KC3 127) chain C residue 2793 type sequence A description BINDING SITE FOR RESIDUE ORN C 3920 source : KC3 128) chain C residue 2892 type sequence E description BINDING SITE FOR RESIDUE ORN C 3920 source : KC3 129) chain C residue 2893 type sequence V description BINDING SITE FOR RESIDUE ORN C 3920 source : KC3 130) chain C residue 2907 type sequence L description BINDING SITE FOR RESIDUE ORN C 3920 source : KC3 131) chain C residue 3040 type sequence Y description BINDING SITE FOR RESIDUE ORN C 3920 source : KC3 132) chain C residue 3041 type sequence D description BINDING SITE FOR RESIDUE ORN C 3920 source : KC3 133) chain C residue 3042 type sequence T description BINDING SITE FOR RESIDUE ORN C 3920 source : KC3 134) chain C residue 2094 type sequence T description BINDING SITE FOR RESIDUE NET C 3950 source : KC4 135) chain C residue 2097 type sequence N description BINDING SITE FOR RESIDUE NET C 3950 source : KC4 136) chain C residue 2936 type sequence N description BINDING SITE FOR RESIDUE NET C 3950 source : KC4 137) chain C residue 2304 type catalytic sequence V description 435 source MCSA : MCSA2 138) chain C residue 2716 type catalytic sequence A description 435 source MCSA : MCSA2 139) chain C residue 2762 type catalytic sequence V description 435 source MCSA : MCSA2 140) chain C residue 2830 type catalytic sequence F description 435 source MCSA : MCSA2 141) chain C residue 2842 type catalytic sequence V description 435 source MCSA : MCSA2 142) chain C residue 2844 type catalytic sequence P description 435 source MCSA : MCSA2 143) chain C residue 2849 type catalytic sequence T description 435 source MCSA : MCSA2 144) chain C residue 2216 type catalytic sequence Y description 435 source MCSA : MCSA2 145) chain C residue 2244 type catalytic sequence T description 435 source MCSA : MCSA2 146) chain C residue 2284 type catalytic sequence V description 435 source MCSA : MCSA2 147) chain C residue 2286 type catalytic sequence F description 435 source MCSA : MCSA2 148) chain C residue 2300 type catalytic sequence M description 435 source MCSA : MCSA2 149) chain C residue 2302 type catalytic sequence P description 435 source MCSA : MCSA2 150) chain C residue 2130 type ACT_SITE sequence R description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 151) chain C residue 2170 type ACT_SITE sequence P description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 152) chain C residue 2176 type ACT_SITE sequence G description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 153) chain C residue 2177 type ACT_SITE sequence S description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 154) chain C residue 2209 type ACT_SITE sequence S description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 155) chain C residue 2211 type ACT_SITE sequence I description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 156) chain C residue 2216 type ACT_SITE sequence Y description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 157) chain C residue 2242 type ACT_SITE sequence I description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 158) chain C residue 2243 type ACT_SITE sequence H description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 159) chain C residue 2244 type ACT_SITE sequence T description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 160) chain C residue 2716 type ACT_SITE sequence A description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 161) chain C residue 2755 type ACT_SITE sequence F description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 162) chain C residue 2757 type ACT_SITE sequence D description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 163) chain C residue 2762 type ACT_SITE sequence V description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 164) chain C residue 2787 type ACT_SITE sequence V description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 165) chain C residue 2788 type ACT_SITE sequence H description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 166) chain C residue 2789 type ACT_SITE sequence S description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 167) chain C residue 2790 type ACT_SITE sequence G description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 168) chain C residue 2830 type BINDING sequence F description BINDING => ECO:0000255|HAMAP-Rule:MF_01210, ECO:0000269|PubMed:10428826, ECO:0000269|PubMed:9636022, ECO:0007744|PDB:1CE8 source Swiss-Prot : SWS_FT_FI4 169) chain C residue 2842 type BINDING sequence V description BINDING => ECO:0000255|HAMAP-Rule:MF_01210, ECO:0000269|PubMed:10029528, ECO:0000269|PubMed:10089390, ECO:0000269|PubMed:10428826, ECO:0000269|PubMed:9636022, ECO:0007744|PDB:1CE8 source Swiss-Prot : SWS_FT_FI5 170) chain C residue 2844 type BINDING sequence P description BINDING => ECO:0000255|HAMAP-Rule:MF_01210, ECO:0000269|PubMed:10029528, ECO:0000269|PubMed:10089390 source Swiss-Prot : SWS_FT_FI6

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