eF-site ID 1a9x-A PDB Code 1a9x Chain A click to enlarge Title CARBAMOYL PHOSPHATE SYNTHETASE: CAUGHT IN THE ACT OF GLUTAMINE HYDROLYSIS Classification AMIDOTRANSFERASE Compound CARBAMOYL PHOSPHATE SYNTHETASE (LARGE CHAIN) Source null (CARA_ECOLI) Sequence A:  MPKRTDIKSILILGAGPIVIGQACEFDYSGAQACKALREE GYRVINVNSNPATIMTDPEMADATYIEPIHWEVVRKIIEK ERPDAVLPTMGGQTALNCALELERQGVLEEFGVTMIGATA DAIDKAEDRRRFDVAMKKIGLETARSGIAHTMEEALAVAA DVGFPCIIRPSFTMGGSGGGIAYNREEFEEICARGLDLSP TKELLIDESLIGWKEYEMEVVRDKNDNCIIVCSIENFDAM GIHTGDSITVAPAQTLTDKEYQIMRNASMAVLREIGVETG GSNVQFAVNPKNGRLIVIEMNPRVSRSSALASKATGFPIA KVAAKLAVGYTLDELMNDITGGRTPASFEPSIDYVVTKIP RFNFEKFAGANDRLTTQMKSVGEVMAIGRTQQESLQKALR GLEVGATGFDPKVSLDDPEALTKIRRELKDAGADRIWYIA DAFRAGLSVDGVFNLTNIDRWFLVQIEELVRLEEKVAEVG ITGLNADFLRQLKRKGFADARLAKLAGVREAEIRKLRDQY DLHPVYKRVDTCAAEFATDTAYMYSTYEEECEANPSTDRE KIMVLGGGPNRIGQGIEFDYCCVHASLALREDGYETIMVN CNPETVSTDYDTSDRLYFEPVTLEDVLEIVRIEKPKGVIV QYGGQTPLKLARALEAAGVPVIGTSPDAIDRAEDRERFQH AVERLKLKQPANATVTAIEMAVEKAKEIGYPLVVRAAMEI VYDEADLRRYFQTAVLLDHFLDDAVEVDVDAICDGEMVLI GGIMEHIEQAGVHSGDSACSLPAYTLSQEIQDVMRQQVQK LAFELQVRGLMNVQFAVKNNEVYLIEVNPRAARTVPFVSK ATGVPLAKVAARVMAGKSLAEQGVTKEVIPPYYSVKEVVL PFNKFPGVDPLLGPEMRSTGEVMGVGRTFAEAFAKAQLGS NSTMKKHGRALLSVREGDKERVVDLAAKLLKQGFELDATH GTAIVLGEAGINPRLVNKVHEGRPHIQDRIKNGEYTYIIN TTSGRRAIEDSRVIRRSALQYKVHYDTTLNGGFATAMALN ADATEKVISVQEMHAQIK Description Functional site 1) chain A residue 129 type sequence R description ADP BINDING SITE. source : AD1 2) chain A residue 169 type sequence R description ADP BINDING SITE. source : AD1 3) chain A residue 176 type sequence G description ADP BINDING SITE. source : AD1 4) chain A residue 208 type sequence E description ADP BINDING SITE. source : AD1 5) chain A residue 210 type sequence L description ADP BINDING SITE. source : AD1 6) chain A residue 215 type sequence E description ADP BINDING SITE. source : AD1 7) chain A residue 241 type sequence G description ADP BINDING SITE. source : AD1 8) chain A residue 242 type sequence I description ADP BINDING SITE. source : AD1 9) chain A residue 243 type sequence H description ADP BINDING SITE. source : AD1 10) chain A residue 285 type sequence Q description ADP BINDING SITE. source : AD1 11) chain A residue 299 type sequence E description ADP BINDING SITE. source : AD1 12) chain A residue 715 type sequence R description ADP BINDING SITE. source : AD2 13) chain A residue 754 type sequence H description ADP BINDING SITE. source : AD2 14) chain A residue 756 type sequence L description ADP BINDING SITE. source : AD2 15) chain A residue 761 type sequence E description ADP BINDING SITE. source : AD2 16) chain A residue 786 type sequence G description ADP BINDING SITE. source : AD2 17) chain A residue 787 type sequence V description ADP BINDING SITE. source : AD2 18) chain A residue 788 type sequence H description ADP BINDING SITE. source : AD2 19) chain A residue 841 type sequence E description ADP BINDING SITE. source : AD2 20) chain A residue 791 type sequence D description ORNITHINE BINDING SITE. source : OR1 21) chain A residue 783 type sequence E description ORNITHINE BINDING SITE. source : OR1 22) chain A residue 892 type sequence E description ORNITHINE BINDING SITE. source : OR1 23) chain A residue 1040 type sequence Y description ORNITHINE BINDING SITE. source : OR1 24) chain A residue 1042 type sequence T description ORNITHINE BINDING SITE. source : OR1 25) chain A residue 798 type sequence A description BINDING SITE FOR RESIDUE PO4 A 1981 source : CC2 26) chain A residue 801 type sequence L description BINDING SITE FOR RESIDUE PO4 A 1981 source : CC2 27) chain A residue 560 type sequence E description BINDING SITE FOR RESIDUE PO4 A 1982 source : CC3 28) chain A residue 592 type sequence D description BINDING SITE FOR RESIDUE PO4 A 1982 source : CC3 29) chain A residue 593 type sequence G description BINDING SITE FOR RESIDUE PO4 A 1982 source : CC3 30) chain A residue 299 type sequence E description BINDING SITE FOR RESIDUE MN A 1901 source : HC5 31) chain A residue 301 type sequence N description BINDING SITE FOR RESIDUE MN A 1901 source : HC5 32) chain A residue 285 type sequence Q description BINDING SITE FOR RESIDUE MN A 1902 source : HC6 33) chain A residue 299 type sequence E description BINDING SITE FOR RESIDUE MN A 1902 source : HC6 34) chain A residue 215 type sequence E description BINDING SITE FOR RESIDUE K A 1903 source : HC7 35) chain A residue 236 type sequence N description BINDING SITE FOR RESIDUE K A 1903 source : HC7 36) chain A residue 238 type sequence D description BINDING SITE FOR RESIDUE K A 1903 source : HC7 37) chain A residue 239 type sequence A description BINDING SITE FOR RESIDUE K A 1903 source : HC7 38) chain A residue 242 type sequence I description BINDING SITE FOR RESIDUE K A 1903 source : HC7 39) chain A residue 247 type sequence S description BINDING SITE FOR RESIDUE K A 1903 source : HC7 40) chain A residue 126 type sequence A description BINDING SITE FOR RESIDUE K A 1904 source : HC8 41) chain A residue 127 type sequence E description BINDING SITE FOR RESIDUE K A 1904 source : HC8 42) chain A residue 299 type sequence E description BINDING SITE FOR RESIDUE K A 1904 source : HC8 43) chain A residue 300 type sequence M description BINDING SITE FOR RESIDUE K A 1904 source : HC8 44) chain A residue 301 type sequence N description BINDING SITE FOR RESIDUE K A 1904 source : HC8 45) chain A residue 174 type sequence M description BINDING SITE FOR RESIDUE PO4 A 1906 source : HC9 46) chain A residue 175 type sequence G description BINDING SITE FOR RESIDUE PO4 A 1906 source : HC9 47) chain A residue 243 type sequence H description BINDING SITE FOR RESIDUE PO4 A 1906 source : HC9 48) chain A residue 285 type sequence Q description BINDING SITE FOR RESIDUE PO4 A 1906 source : HC9 49) chain A residue 299 type sequence E description BINDING SITE FOR RESIDUE PO4 A 1906 source : HC9 50) chain A residue 301 type sequence N description BINDING SITE FOR RESIDUE PO4 A 1906 source : HC9 51) chain A residue 303 type sequence R description BINDING SITE FOR RESIDUE PO4 A 1906 source : HC9 52) chain A residue 306 type sequence R description BINDING SITE FOR RESIDUE PO4 A 1906 source : HC9 53) chain A residue 829 type sequence Q description BINDING SITE FOR RESIDUE MN A 1911 source : IC1 54) chain A residue 841 type sequence E description BINDING SITE FOR RESIDUE MN A 1911 source : IC1 55) chain A residue 841 type sequence E description BINDING SITE FOR RESIDUE K A 1912 source : IC2 56) chain A residue 843 type sequence N description BINDING SITE FOR RESIDUE K A 1912 source : IC2 57) chain A residue 761 type sequence E description BINDING SITE FOR RESIDUE K A 1913 source : IC3 58) chain A residue 781 type sequence H description BINDING SITE FOR RESIDUE K A 1913 source : IC3 59) chain A residue 783 type sequence E description BINDING SITE FOR RESIDUE K A 1913 source : IC3 60) chain A residue 784 type sequence Q description BINDING SITE FOR RESIDUE K A 1913 source : IC3 61) chain A residue 787 type sequence V description BINDING SITE FOR RESIDUE K A 1913 source : IC3 62) chain A residue 792 type sequence S description BINDING SITE FOR RESIDUE K A 1913 source : IC3 63) chain A residue 93 type sequence Q description BINDING SITE FOR RESIDUE CL A 1930 source : IC4 64) chain A residue 173 type sequence T description BINDING SITE FOR RESIDUE CL A 1930 source : IC4 65) chain A residue 174 type sequence M description BINDING SITE FOR RESIDUE CL A 1930 source : IC4 66) chain A residue 289 type sequence N description BINDING SITE FOR RESIDUE CL A 1931 source : IC5 67) chain A residue 292 type sequence N description BINDING SITE FOR RESIDUE CL A 1931 source : IC5 68) chain A residue 294 type sequence R description BINDING SITE FOR RESIDUE CL A 1931 source : IC5 69) chain A residue 370 type sequence A description BINDING SITE FOR RESIDUE CL A 1932 source : IC6 70) chain A residue 371 type sequence N description BINDING SITE FOR RESIDUE CL A 1932 source : IC6 71) chain A residue 900 type sequence F description BINDING SITE FOR RESIDUE CL A 1932 source : IC6 72) chain A residue 901 type sequence P description BINDING SITE FOR RESIDUE CL A 1932 source : IC6 73) chain A residue 902 type sequence G description BINDING SITE FOR RESIDUE CL A 1932 source : IC6 74) chain A residue 578 type sequence F description BINDING SITE FOR RESIDUE CL A 1934 source : IC8 75) chain A residue 845 type sequence R description BINDING SITE FOR RESIDUE CL A 1934 source : IC8 76) chain A residue 847 type sequence A description BINDING SITE FOR RESIDUE CL A 1934 source : IC8 77) chain A residue 848 type sequence R description BINDING SITE FOR RESIDUE CL A 1934 source : IC8 78) chain A residue 71 type sequence W description BINDING SITE FOR RESIDUE CL A 1935 source : IC9 79) chain A residue 475 type sequence K description BINDING SITE FOR RESIDUE CL A 1936 source : JC1 80) chain A residue 485 type sequence N description BINDING SITE FOR RESIDUE CL A 1936 source : JC1 81) chain A residue 488 type sequence F description BINDING SITE FOR RESIDUE CL A 1936 source : JC1 82) chain A residue 84 type sequence D description BINDING SITE FOR RESIDUE K A 1940 source : JC2 83) chain A residue 112 type sequence G description BINDING SITE FOR RESIDUE K A 1940 source : JC2 84) chain A residue 114 type sequence T description BINDING SITE FOR RESIDUE K A 1940 source : JC2 85) chain A residue 217 type sequence E description BINDING SITE FOR RESIDUE K A 1942 source : JC4 86) chain A residue 244 type sequence T description BINDING SITE FOR RESIDUE K A 1942 source : JC4 87) chain A residue 283 type sequence N description BINDING SITE FOR RESIDUE K A 1942 source : JC4 88) chain A residue 285 type sequence Q description BINDING SITE FOR RESIDUE K A 1942 source : JC4 89) chain A residue 307 type sequence S description BINDING SITE FOR RESIDUE K A 1942 source : JC4 90) chain A residue 143 type sequence T description BINDING SITE FOR RESIDUE K A 1943 source : JC5 91) chain A residue 144 type sequence A description BINDING SITE FOR RESIDUE K A 1943 source : JC5 92) chain A residue 129 type sequence R description BINDING SITE FOR RESIDUE ADP A 1900 source : KC9 93) chain A residue 167 type sequence I description BINDING SITE FOR RESIDUE ADP A 1900 source : KC9 94) chain A residue 169 type sequence R description BINDING SITE FOR RESIDUE ADP A 1900 source : KC9 95) chain A residue 174 type sequence M description BINDING SITE FOR RESIDUE ADP A 1900 source : KC9 96) chain A residue 175 type sequence G description BINDING SITE FOR RESIDUE ADP A 1900 source : KC9 97) chain A residue 176 type sequence G description BINDING SITE FOR RESIDUE ADP A 1900 source : KC9 98) chain A residue 208 type sequence E description BINDING SITE FOR RESIDUE ADP A 1900 source : KC9 99) chain A residue 210 type sequence L description BINDING SITE FOR RESIDUE ADP A 1900 source : KC9 100) chain A residue 215 type sequence E description BINDING SITE FOR RESIDUE ADP A 1900 source : KC9 101) chain A residue 240 type sequence M description BINDING SITE FOR RESIDUE ADP A 1900 source : KC9 102) chain A residue 241 type sequence G description BINDING SITE FOR RESIDUE ADP A 1900 source : KC9 103) chain A residue 242 type sequence I description BINDING SITE FOR RESIDUE ADP A 1900 source : KC9 104) chain A residue 243 type sequence H description BINDING SITE FOR RESIDUE ADP A 1900 source : KC9 105) chain A residue 244 type sequence T description BINDING SITE FOR RESIDUE ADP A 1900 source : KC9 106) chain A residue 285 type sequence Q description BINDING SITE FOR RESIDUE ADP A 1900 source : KC9 107) chain A residue 299 type sequence E description BINDING SITE FOR RESIDUE ADP A 1900 source : KC9 108) chain A residue 376 type sequence T description BINDING SITE FOR RESIDUE ADP A 1900 source : KC9 109) chain A residue 690 type sequence P description BINDING SITE FOR RESIDUE ADP A 1910 source : LC1 110) chain A residue 715 type sequence R description BINDING SITE FOR RESIDUE ADP A 1910 source : LC1 111) chain A residue 725 type sequence M description BINDING SITE FOR RESIDUE ADP A 1910 source : LC1 112) chain A residue 754 type sequence H description BINDING SITE FOR RESIDUE ADP A 1910 source : LC1 113) chain A residue 755 type sequence F description BINDING SITE FOR RESIDUE ADP A 1910 source : LC1 114) chain A residue 756 type sequence L description BINDING SITE FOR RESIDUE ADP A 1910 source : LC1 115) chain A residue 761 type sequence E description BINDING SITE FOR RESIDUE ADP A 1910 source : LC1 116) chain A residue 785 type sequence A description BINDING SITE FOR RESIDUE ADP A 1910 source : LC1 117) chain A residue 786 type sequence G description BINDING SITE FOR RESIDUE ADP A 1910 source : LC1 118) chain A residue 787 type sequence V description BINDING SITE FOR RESIDUE ADP A 1910 source : LC1 119) chain A residue 788 type sequence H description BINDING SITE FOR RESIDUE ADP A 1910 source : LC1 120) chain A residue 789 type sequence S description BINDING SITE FOR RESIDUE ADP A 1910 source : LC1 121) chain A residue 829 type sequence Q description BINDING SITE FOR RESIDUE ADP A 1910 source : LC1 122) chain A residue 841 type sequence E description BINDING SITE FOR RESIDUE ADP A 1910 source : LC1 123) chain A residue 783 type sequence E description BINDING SITE FOR RESIDUE ORN A 1920 source : LC2 124) chain A residue 791 type sequence D description BINDING SITE FOR RESIDUE ORN A 1920 source : LC2 125) chain A residue 793 type sequence A description BINDING SITE FOR RESIDUE ORN A 1920 source : LC2 126) chain A residue 892 type sequence E description BINDING SITE FOR RESIDUE ORN A 1920 source : LC2 127) chain A residue 907 type sequence L description BINDING SITE FOR RESIDUE ORN A 1920 source : LC2 128) chain A residue 1040 type sequence Y description BINDING SITE FOR RESIDUE ORN A 1920 source : LC2 129) chain A residue 1041 type sequence D description BINDING SITE FOR RESIDUE ORN A 1920 source : LC2 130) chain A residue 1042 type sequence T description BINDING SITE FOR RESIDUE ORN A 1920 source : LC2 131) chain A residue 22 type sequence Q description BINDING SITE FOR RESIDUE NET A 1950 source : LC3 132) chain A residue 94 type sequence T description BINDING SITE FOR RESIDUE NET A 1950 source : LC3 133) chain A residue 303 type catalytic sequence R description 435 source MCSA : MCSA1 134) chain A residue 715 type catalytic sequence R description 435 source MCSA : MCSA1 135) chain A residue 761 type catalytic sequence E description 435 source MCSA : MCSA1 136) chain A residue 829 type catalytic sequence Q description 435 source MCSA : MCSA1 137) chain A residue 841 type catalytic sequence E description 435 source MCSA : MCSA1 138) chain A residue 215 type catalytic sequence E description 435 source MCSA : MCSA1 139) chain A residue 243 type catalytic sequence H description 435 source MCSA : MCSA1 140) chain A residue 283 type catalytic sequence N description 435 source MCSA : MCSA1 141) chain A residue 285 type catalytic sequence Q description 435 source MCSA : MCSA1 142) chain A residue 299 type catalytic sequence E description 435 source MCSA : MCSA1 143) chain A residue 301 type catalytic sequence N description 435 source MCSA : MCSA1 144) chain A residue 843 type catalytic sequence N description 435 source MCSA : MCSA1 145) chain A residue 848 type catalytic sequence R description 435 source MCSA : MCSA1 146) chain A residue 164-178 type prosite sequence FPCIIRPSFTMGGSG description CPSASE_1 Carbamoyl-phosphate synthase subdomain signature 1. FPCIIRPSftmGGsG source prosite : PS00866 147) chain A residue 710-724 type prosite sequence YPLVVRAA description CPSASE_1 Carbamoyl-phosphate synthase subdomain signature 1. FPCIIRPSftmGGsG source prosite : PS00866 148) chain A residue 297-304 type prosite sequence VIEMNPRV description CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. VIEMNPRV source prosite : PS00867 149) chain A residue 839-846 type prosite sequence LIEVNPRA description CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. VIEMNPRV source prosite : PS00867 150) chain A residue 843 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_01210, ECO:0000269|PubMed:10029528, ECO:0000269|PubMed:10089390 source Swiss-Prot : SWS_FT_FI6 151) chain A residue 829 type BINDING sequence Q description BINDING => ECO:0000255|HAMAP-Rule:MF_01210, ECO:0000269|PubMed:10428826, ECO:0000269|PubMed:9636022, ECO:0007744|PDB:1CE8 source Swiss-Prot : SWS_FT_FI4 152) chain A residue 243 type ACT_SITE sequence H description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 153) chain A residue 715 type ACT_SITE sequence R description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 154) chain A residue 754 type ACT_SITE sequence H description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 155) chain A residue 756 type ACT_SITE sequence L description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 156) chain A residue 761 type ACT_SITE sequence E description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 157) chain A residue 786 type ACT_SITE sequence G description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 158) chain A residue 787 type ACT_SITE sequence V description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 159) chain A residue 788 type ACT_SITE sequence H description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 160) chain A residue 789 type ACT_SITE sequence S description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 161) chain A residue 242 type ACT_SITE sequence I description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 162) chain A residue 210 type ACT_SITE sequence L description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 163) chain A residue 241 type ACT_SITE sequence G description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 164) chain A residue 208 type ACT_SITE sequence E description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 165) chain A residue 215 type ACT_SITE sequence E description Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 source Swiss-Prot : SWS_FT_FI1 166) chain A residue 841 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_01210, ECO:0000269|PubMed:10029528, ECO:0000269|PubMed:10089390, ECO:0000269|PubMed:10428826, ECO:0000269|PubMed:9636022, ECO:0007744|PDB:1CE8 source Swiss-Prot : SWS_FT_FI5

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