eF-site ID 1a9p-A PDB Code 1a9p Chain A click to enlarge Title BOVINE PURINE NUCLEOSIDE PHOSPHORYLASE COMPLEXED WITH 9-DEAZAINOSINE AND PHOSPHATE Classification PENTOSYLTRANSFERASE Compound PURINE NUCLEOSIDE PHOSPHORYLASE Source ORGANISM_COMMON: cattle; ORGANISM_SCIENTIFIC: Bos taurus; Sequence A:  MQNGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVN KLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVM MQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGL NPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFP AMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNF ETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSL ITNKVIMDTESQGKANHEEVLEAGKQAAQKLEQFVSLLMA SIPVSGHTG Description Functional site 1) chain A residue 88 type sequence Y description source : 9NE 2) chain A residue 201 type sequence E description source : 9NE 3) chain A residue 219 type sequence M description source : 9NE 4) chain A residue 243 type sequence N description source : 9NE 5) chain A residue 257 type sequence H description source : 9NE 6) chain A residue 259 type sequence E description source : 9NE 7) chain A residue 33 type sequence S description source : PNG 8) chain A residue 64 type sequence H description source : PNG 9) chain A residue 84 type sequence R description source : PNG 10) chain A residue 86 type sequence H description source : PNG 11) chain A residue 116 type sequence A description source : PNG 12) chain A residue 220 type sequence S description source : PNG 13) chain A residue 32 type sequence G description BINDING SITE FOR RESIDUE PO4 A 291 source : AC1 14) chain A residue 33 type sequence S description BINDING SITE FOR RESIDUE PO4 A 291 source : AC1 15) chain A residue 64 type sequence H description BINDING SITE FOR RESIDUE PO4 A 291 source : AC1 16) chain A residue 84 type sequence R description BINDING SITE FOR RESIDUE PO4 A 291 source : AC1 17) chain A residue 86 type sequence H description BINDING SITE FOR RESIDUE PO4 A 291 source : AC1 18) chain A residue 115 type sequence N description BINDING SITE FOR RESIDUE PO4 A 291 source : AC1 19) chain A residue 116 type sequence A description BINDING SITE FOR RESIDUE PO4 A 291 source : AC1 20) chain A residue 220 type sequence S description BINDING SITE FOR RESIDUE PO4 A 291 source : AC1 21) chain A residue 86 type sequence H description BINDING SITE FOR RESIDUE 9DI A 290 source : AC2 22) chain A residue 88 type sequence Y description BINDING SITE FOR RESIDUE 9DI A 290 source : AC2 23) chain A residue 116 type sequence A description BINDING SITE FOR RESIDUE 9DI A 290 source : AC2 24) chain A residue 118 type sequence G description BINDING SITE FOR RESIDUE 9DI A 290 source : AC2 25) chain A residue 200 type sequence F description BINDING SITE FOR RESIDUE 9DI A 290 source : AC2 26) chain A residue 201 type sequence E description BINDING SITE FOR RESIDUE 9DI A 290 source : AC2 27) chain A residue 219 type sequence M description BINDING SITE FOR RESIDUE 9DI A 290 source : AC2 28) chain A residue 242 type sequence T description BINDING SITE FOR RESIDUE 9DI A 290 source : AC2 29) chain A residue 243 type sequence N description BINDING SITE FOR RESIDUE 9DI A 290 source : AC2 30) chain A residue 257 type sequence H description BINDING SITE FOR RESIDUE 9DI A 290 source : AC2 31) chain A residue 259 type sequence E description BINDING SITE FOR RESIDUE 9DI A 290 source : AC2 32) chain A residue 64 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9T, ECO:0007744|PDB:3PNP, ECO:0007744|PDB:4PNP source Swiss-Prot : SWS_FT_FI2 33) chain A residue 84 type BINDING sequence R description BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9O, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9Q, ECO:0007744|PDB:1A9R, ECO:0007744|PDB:1A9S, ECO:0007744|PDB:1A9T, ECO:0007744|PDB:3PNP, ECO:0007744|PDB:4PNP source Swiss-Prot : SWS_FT_FI3 34) chain A residue 116 type BINDING sequence A description BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9O, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9Q, ECO:0007744|PDB:1A9R, ECO:0007744|PDB:1A9S, ECO:0007744|PDB:1A9T, ECO:0007744|PDB:3PNP, ECO:0007744|PDB:4PNP source Swiss-Prot : SWS_FT_FI3 35) chain A residue 220 type BINDING sequence S description BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9O, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9Q, ECO:0007744|PDB:1A9R, ECO:0007744|PDB:1A9S, ECO:0007744|PDB:1A9T, ECO:0007744|PDB:3PNP, ECO:0007744|PDB:4PNP source Swiss-Prot : SWS_FT_FI3 36) chain A residue 88 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9S, ECO:0007744|PDB:1A9T source Swiss-Prot : SWS_FT_FI4 37) chain A residue 219 type BINDING sequence M description BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9S, ECO:0007744|PDB:1A9T source Swiss-Prot : SWS_FT_FI4 38) chain A residue 257 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9S, ECO:0007744|PDB:1A9T source Swiss-Prot : SWS_FT_FI4 39) chain A residue 243 type SITE sequence N description Important for substrate specificity => ECO:0000250|UniProtKB:P00491 source Swiss-Prot : SWS_FT_FI6 40) chain A residue 79-120 type prosite sequence VMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAG GL description PNP_MTAP_2 Purine and other phosphorylases family 2 signature. VmmqGrfHmYegypFwkvTfpVrVfrllGvet.LVvtNAaGGL source prosite : PS01240 41) chain A residue 33 type BINDING sequence S description BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9O, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9S, ECO:0007744|PDB:1A9T, ECO:0007744|PDB:3PNP, ECO:0007744|PDB:4PNP source Swiss-Prot : SWS_FT_FI1 42) chain A residue 201 type BINDING sequence E description BINDING => ECO:0000269|PubMed:9585525, ECO:0000305|PubMed:9020983, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9Q, ECO:0007744|PDB:1A9R, ECO:0007744|PDB:1VFN source Swiss-Prot : SWS_FT_FI5 43) chain A residue 243 type BINDING sequence N description BINDING => ECO:0000269|PubMed:9585525, ECO:0000305|PubMed:9020983, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9Q, ECO:0007744|PDB:1A9R, ECO:0007744|PDB:1VFN source Swiss-Prot : SWS_FT_FI5 44) chain A residue 1 type MOD_RES sequence M description N-acetylmethionine => ECO:0000250|UniProtKB:P00491 source Swiss-Prot : SWS_FT_FI7 45) chain A residue 251 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P00491 source Swiss-Prot : SWS_FT_FI8

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