|
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eF-site ID
|
1a9o-A |
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PDB Code
|
1a9o |
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Chain
|
A |
|
click to enlarge
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Title
|
BOVINE PURINE NUCLEOSIDE PHOSPHORYLASE COMPLEXED WITH PHOSPHATE |
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Classification
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PENTOSYLTRANSFERASE |
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Compound
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PURINE NUCLEOSIDE PHOSPHORYLASE |
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Source
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ORGANISM_COMMON: cattle; ORGANISM_SCIENTIFIC: Bos taurus; |
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Sequence
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A: |
MQNGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVN
KLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVM
MQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGL
NPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFP
AMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNF
ETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDTESQGKANHEEVLEAGKQAAQKLEQFVSLLMA
SIPVSGHTG
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Description
|
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Functional site
|
|
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1)
|
chain |
A |
| residue |
32 |
| type |
|
| sequence |
G
|
| description |
BINDING SITE FOR RESIDUE PO4 A 291
|
| source |
: AC1
|
|
|
2)
|
chain |
A |
| residue |
33 |
| type |
|
| sequence |
S
|
| description |
BINDING SITE FOR RESIDUE PO4 A 291
|
| source |
: AC1
|
|
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3)
|
chain |
A |
| residue |
84 |
| type |
|
| sequence |
R
|
| description |
BINDING SITE FOR RESIDUE PO4 A 291
|
| source |
: AC1
|
|
|
4)
|
chain |
A |
| residue |
86 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE PO4 A 291
|
| source |
: AC1
|
|
|
5)
|
chain |
A |
| residue |
115 |
| type |
|
| sequence |
N
|
| description |
BINDING SITE FOR RESIDUE PO4 A 291
|
| source |
: AC1
|
|
|
6)
|
chain |
A |
| residue |
116 |
| type |
|
| sequence |
A
|
| description |
BINDING SITE FOR RESIDUE PO4 A 291
|
| source |
: AC1
|
|
|
7)
|
chain |
A |
| residue |
220 |
| type |
|
| sequence |
S
|
| description |
BINDING SITE FOR RESIDUE PO4 A 291
|
| source |
: AC1
|
|
|
8)
|
chain |
A |
| residue |
1 |
| type |
MOD_RES |
| sequence |
M
|
| description |
N-acetylmethionine => ECO:0000250|UniProtKB:P00491
|
| source |
Swiss-Prot : SWS_FT_FI7
|
|
|
9)
|
chain |
A |
| residue |
251 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000250|UniProtKB:P00491
|
| source |
Swiss-Prot : SWS_FT_FI8
|
|
|
10)
|
chain |
A |
| residue |
243 |
| type |
SITE |
| sequence |
N
|
| description |
Important for substrate specificity => ECO:0000250|UniProtKB:P00491
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
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11)
|
chain |
A |
| residue |
79-120 |
| type |
prosite |
| sequence |
VMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAG
GL
|
| description |
PNP_MTAP_2 Purine and other phosphorylases family 2 signature. VmmqGrfHmYegypFwkvTfpVrVfrllGvet.LVvtNAaGGL
|
| source |
prosite : PS01240
|
|
|
12)
|
chain |
A |
| residue |
33 |
| type |
BINDING |
| sequence |
S
|
| description |
BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9O, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9S, ECO:0007744|PDB:1A9T, ECO:0007744|PDB:3PNP, ECO:0007744|PDB:4PNP
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
13)
|
chain |
A |
| residue |
64 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9T, ECO:0007744|PDB:3PNP, ECO:0007744|PDB:4PNP
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
14)
|
chain |
A |
| residue |
116 |
| type |
BINDING |
| sequence |
A
|
| description |
BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9O, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9Q, ECO:0007744|PDB:1A9R, ECO:0007744|PDB:1A9S, ECO:0007744|PDB:1A9T, ECO:0007744|PDB:3PNP, ECO:0007744|PDB:4PNP
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
15)
|
chain |
A |
| residue |
220 |
| type |
BINDING |
| sequence |
S
|
| description |
BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9O, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9Q, ECO:0007744|PDB:1A9R, ECO:0007744|PDB:1A9S, ECO:0007744|PDB:1A9T, ECO:0007744|PDB:3PNP, ECO:0007744|PDB:4PNP
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
16)
|
chain |
A |
| residue |
84 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9O, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9Q, ECO:0007744|PDB:1A9R, ECO:0007744|PDB:1A9S, ECO:0007744|PDB:1A9T, ECO:0007744|PDB:3PNP, ECO:0007744|PDB:4PNP
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
17)
|
chain |
A |
| residue |
88 |
| type |
BINDING |
| sequence |
Y
|
| description |
BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9S, ECO:0007744|PDB:1A9T
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
18)
|
chain |
A |
| residue |
219 |
| type |
BINDING |
| sequence |
M
|
| description |
BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9S, ECO:0007744|PDB:1A9T
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
19)
|
chain |
A |
| residue |
257 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9S, ECO:0007744|PDB:1A9T
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
20)
|
chain |
A |
| residue |
243 |
| type |
BINDING |
| sequence |
N
|
| description |
BINDING => ECO:0000269|PubMed:9585525, ECO:0000305|PubMed:9020983, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9Q, ECO:0007744|PDB:1A9R, ECO:0007744|PDB:1VFN
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
21)
|
chain |
A |
| residue |
201 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000269|PubMed:9585525, ECO:0000305|PubMed:9020983, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9Q, ECO:0007744|PDB:1A9R, ECO:0007744|PDB:1VFN
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
|