eF-site ID 1a94-ABDE PDB Code 1a94 Chain A, B, D, E click to enlarge Title STRUCTURAL BASIS FOR SPECIFICITY OF RETROVIRAL PROTEASES Classification HYDROLASE/HYDROLASE INHIBITOR Compound PROTEASE Source null (POL_HV1BR) Sequence A:  PQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPG RWEPKMIGGIGGFIKVRQYDQIIIEIAGHKAIGTVLVGPT PVNIIGRNLLTQIGATLNF B:  PQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPG RWEPKMIGGIGGFIKVRQYDQIIIEIAGHKAIGTVLVGPT PVNIIGRNLLTQIGATLNF D:  PQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPG RWEPKMIGGIGGFIKVRQYDQIIIEIAGHKAIGTVLVGPT PVNIIGRNLLTQIGATLNF E:  PQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPG RWEPKMIGGIGGFIKVRQYDQIIIEIAGHKAIGTVLVGPT PVNIIGRNLLTQIGATLNF Description Functional site 1) chain A residue 8 type sequence R description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 2) chain A residue 23 type sequence L description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 3) chain A residue 25 type sequence D description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 4) chain A residue 27 type sequence G description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 5) chain A residue 28 type sequence A description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 6) chain A residue 29 type sequence D description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 7) chain A residue 30 type sequence D description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 8) chain A residue 46 type sequence M description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 9) chain A residue 47 type sequence I description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 10) chain A residue 48 type sequence G description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 11) chain A residue 49 type sequence G description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 12) chain A residue 81 type sequence P description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 13) chain A residue 82 type sequence V description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 14) chain B residue 25 type sequence D description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 15) chain B residue 27 type sequence G description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 16) chain B residue 28 type sequence A description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 17) chain B residue 29 type sequence D description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 18) chain B residue 30 type sequence D description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 19) chain B residue 48 type sequence G description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 20) chain B residue 49 type sequence G description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 21) chain B residue 84 type sequence I description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 22) chain E residue 6 type sequence W description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 23) chain B residue 6 type sequence W description BINDING SITE FOR RESIDUE 0Q4 E 100 source : AC2 24) chain D residue 8 type sequence R description BINDING SITE FOR RESIDUE 0Q4 E 100 source : AC2 25) chain D residue 23 type sequence L description BINDING SITE FOR RESIDUE 0Q4 E 100 source : AC2 26) chain D residue 25 type sequence D description BINDING SITE FOR RESIDUE 0Q4 E 100 source : AC2 27) chain D residue 27 type sequence G description BINDING SITE FOR RESIDUE 0Q4 E 100 source : AC2 28) chain D residue 28 type sequence A description BINDING SITE FOR RESIDUE 0Q4 E 100 source : AC2 29) chain D residue 29 type sequence D description BINDING SITE FOR RESIDUE 0Q4 E 100 source : AC2 30) chain D residue 46 type sequence M description BINDING SITE FOR RESIDUE 0Q4 E 100 source : AC2 31) chain D residue 48 type sequence G description BINDING SITE FOR RESIDUE 0Q4 E 100 source : AC2 32) chain D residue 49 type sequence G description BINDING SITE FOR RESIDUE 0Q4 E 100 source : AC2 33) chain D residue 50 type sequence I description BINDING SITE FOR RESIDUE 0Q4 E 100 source : AC2 34) chain D residue 81 type sequence P description BINDING SITE FOR RESIDUE 0Q4 E 100 source : AC2 35) chain D residue 82 type sequence V description BINDING SITE FOR RESIDUE 0Q4 E 100 source : AC2 36) chain D residue 84 type sequence I description BINDING SITE FOR RESIDUE 0Q4 E 100 source : AC2 37) chain E residue 25 type sequence D description BINDING SITE FOR RESIDUE 0Q4 E 100 source : AC2 38) chain E residue 27 type sequence G description BINDING SITE FOR RESIDUE 0Q4 E 100 source : AC2 39) chain E residue 28 type sequence A description BINDING SITE FOR RESIDUE 0Q4 E 100 source : AC2 40) chain E residue 29 type sequence D description BINDING SITE FOR RESIDUE 0Q4 E 100 source : AC2 41) chain E residue 30 type sequence D description BINDING SITE FOR RESIDUE 0Q4 E 100 source : AC2 42) chain E residue 45 type sequence K description BINDING SITE FOR RESIDUE 0Q4 E 100 source : AC2 43) chain E residue 46 type sequence M description BINDING SITE FOR RESIDUE 0Q4 E 100 source : AC2 44) chain E residue 47 type sequence I description BINDING SITE FOR RESIDUE 0Q4 E 100 source : AC2 45) chain E residue 48 type sequence G description BINDING SITE FOR RESIDUE 0Q4 E 100 source : AC2 46) chain E residue 49 type sequence G description BINDING SITE FOR RESIDUE 0Q4 E 100 source : AC2 47) chain E residue 50 type sequence I description BINDING SITE FOR RESIDUE 0Q4 E 100 source : AC2 48) chain E residue 53 type sequence F description BINDING SITE FOR RESIDUE 0Q4 E 100 source : AC2 49) chain A residue 64 type SITE sequence I description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 50) chain B residue 64 type SITE sequence I description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 51) chain D residue 64 type SITE sequence I description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 52) chain E residue 64 type SITE sequence I description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 53) chain A residue 64 type MOD_RES sequence I description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 54) chain B residue 64 type MOD_RES sequence I description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 55) chain D residue 64 type MOD_RES sequence I description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 56) chain E residue 64 type MOD_RES sequence I description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 57) chain A residue 22-33 type prosite sequence ALLDTGADDTVI description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI source prosite : PS00141

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