eF-site ID 1a94-A PDB Code 1a94 Chain A click to enlarge Title STRUCTURAL BASIS FOR SPECIFICITY OF RETROVIRAL PROTEASES Classification HYDROLASE/HYDROLASE INHIBITOR Compound PROTEASE Source Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1) (POL_HV1BR) Sequence A:  PQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPG RWEPKMIGGIGGFIKVRQYDQIIIEIAGHKAIGTVLVGPT PVNIIGRNLLTQIGATLNF Description Functional site 1) chain A residue 8 type sequence R description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 2) chain A residue 23 type sequence L description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 3) chain A residue 25 type sequence D description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 4) chain A residue 27 type sequence G description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 5) chain A residue 28 type sequence A description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 6) chain A residue 29 type sequence D description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 7) chain A residue 30 type sequence D description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 8) chain A residue 46 type sequence M description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 9) chain A residue 47 type sequence I description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 10) chain A residue 48 type sequence G description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 11) chain A residue 49 type sequence G description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 12) chain A residue 81 type sequence P description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 13) chain A residue 82 type sequence V description BINDING SITE FOR RESIDUE 0Q4 A 100 source : AC1 14) chain A residue 64 type SITE sequence I description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 15) chain A residue 64 type MOD_RES sequence I description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 16) chain A residue 22-33 type prosite sequence ALLDTGADDTVI description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI source prosite : PS00141

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