eF-site ID 1a7k-ABCD PDB Code 1a7k Chain A, B, C, D click to enlarge Title GLYCOSOMAL GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE IN A MONOCLINIC CRYSTAL FORM Classification OXIDOREDUCTASE Compound GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE Source Leishmania mexicana (G3PG_LEIME) Sequence A:  APIKVGINGFGRIGRMVFQAICDQGLIGTEIDVVAVVDMS TNAEYFAYQMKHDTVHGRPKYTVEAVKSSPSVETADVLVV NGHRIKCVKAQRNPADLPWGKLGVDYVIESTGLFTDKLKA EGHIKGGAKKVVISAPASGGAKTIVMGVNQHEYSPASHHV VSNASCTTNCLAPIVHVLTKENFGIETGLMTTIHSYTATQ KTVDGVSLKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTK GKLTGMSFRVPTPDVSVVDLTFRATRDTSIQEIDKAIKKA AQTYMKGILGFTDEELVSADFINDNRSSVYDSKATLQNNL PGEKRFFKVVSWYDNEWAYSHRVVDLVRYMAAKDAASS B:  APIKVGINGFGRIGRMVFQAICDQGLIGTEIDVVAVVDMS TNAEYFAYQMKHDTVHGRPKYTVEAVKSSPSVETADVLVV NGHRIKCVKAQRNPADLPWGKLGVDYVIESTGLFTDKLKA EGHIKGGAKKVVISAPASGGAKTIVMGVNQHEYSPASHHV VSNASCTTNCLAPIVHVLTKENFGIETGLMTTIHSYTATQ KTVDGVSLKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTK GKLTGMSFRVPTPDVSVVDLTFRATRDTSIQEIDKAIKKA AQTYMKGILGFTDEELVSADFINDNRSSVYDSKATLQNNL PGEKRFFKVVSWYDNEWAYSHRVVDLVRYMAAKDAASS C:  APIKVGINGFGRIGRMVFQAICDQGLIGTEIDVVAVVDMS TNAEYFAYQMKHDTVHGRPKYTVEAVKSSPSVETADVLVV NGHRIKCVKAQRNPADLPWGKLGVDYVIESTGLFTDKLKA EGHIKGGAKKVVISAPASGGAKTIVMGVNQHEYSPASHHV VSNASCTTNCLAPIVHVLTKENFGIETGLMTTIHSYTATQ KTVDGVSLKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTK GKLTGMSFRVPTPDVSVVDLTFRATRDTSIQEIDKAIKKA AQTYMKGILGFTDEELVSADFINDNRSSVYDSKATLQNNL PGEKRFFKVVSWYDNEWAYSHRVVDLVRYMAAKDAASS D:  APIKVGINGFGRIGRMVFQAICDQGLIGTEIDVVAVVDMS TNAEYFAYQMKHDTVHGRPKYTVEAVKSSPSVETADVLVV NGHRIKCVKAQRNPADLPWGKLGVDYVIESTGLFTDKLKA EGHIKGGAKKVVISAPASGGAKTIVMGVNQHEYSPASHHV VSNASCTTNCLAPIVHVLTKENFGIETGLMTTIHSYTATQ KTVDGVSLKDWRGGRAAAVNIIPSTTGAAKAVGMVIPSTK GKLTGMSFRVPTPDVSVVDLTFRATRDTSIQEIDKAIKKA AQTYMKGILGFTDEELVSADFINDNRSSVYDSKATLQNNL PGEKRFFKVVSWYDNEWAYSHRVVDLVRYMAAKDAASS Description Functional site 1) chain A residue 165 type sequence S description BINDING SITE FOR RESIDUE PO4 A 361 source : AC1 2) chain A residue 166 type sequence C description BINDING SITE FOR RESIDUE PO4 A 361 source : AC1 3) chain A residue 167 type sequence T description BINDING SITE FOR RESIDUE PO4 A 361 source : AC1 4) chain A residue 194 type sequence H description BINDING SITE FOR RESIDUE PO4 A 361 source : AC1 5) chain A residue 225 type sequence T description BINDING SITE FOR RESIDUE PO4 A 361 source : AC1 6) chain A residue 226 type sequence T description BINDING SITE FOR RESIDUE PO4 A 361 source : AC1 7) chain A residue 227 type sequence G description BINDING SITE FOR RESIDUE PO4 A 361 source : AC1 8) chain A residue 228 type sequence A description BINDING SITE FOR RESIDUE PO4 A 361 source : AC1 9) chain A residue 197 type sequence T description BINDING SITE FOR RESIDUE PO4 A 362 source : AC2 10) chain A residue 199 type sequence T description BINDING SITE FOR RESIDUE PO4 A 362 source : AC2 11) chain A residue 249 type sequence R description BINDING SITE FOR RESIDUE PO4 A 362 source : AC2 12) chain B residue 165 type sequence S description BINDING SITE FOR RESIDUE PO4 B 361 source : AC3 13) chain B residue 166 type sequence C description BINDING SITE FOR RESIDUE PO4 B 361 source : AC3 14) chain B residue 167 type sequence T description BINDING SITE FOR RESIDUE PO4 B 361 source : AC3 15) chain B residue 194 type sequence H description BINDING SITE FOR RESIDUE PO4 B 361 source : AC3 16) chain B residue 226 type sequence T description BINDING SITE FOR RESIDUE PO4 B 361 source : AC3 17) chain B residue 227 type sequence G description BINDING SITE FOR RESIDUE PO4 B 361 source : AC3 18) chain B residue 228 type sequence A description BINDING SITE FOR RESIDUE PO4 B 361 source : AC3 19) chain B residue 197 type sequence T description BINDING SITE FOR RESIDUE PO4 B 362 source : AC4 20) chain B residue 199 type sequence T description BINDING SITE FOR RESIDUE PO4 B 362 source : AC4 21) chain C residue 165 type sequence S description BINDING SITE FOR RESIDUE PO4 C 361 source : AC5 22) chain C residue 166 type sequence C description BINDING SITE FOR RESIDUE PO4 C 361 source : AC5 23) chain C residue 167 type sequence T description BINDING SITE FOR RESIDUE PO4 C 361 source : AC5 24) chain C residue 194 type sequence H description BINDING SITE FOR RESIDUE PO4 C 361 source : AC5 25) chain C residue 226 type sequence T description BINDING SITE FOR RESIDUE PO4 C 361 source : AC5 26) chain C residue 227 type sequence G description BINDING SITE FOR RESIDUE PO4 C 361 source : AC5 27) chain C residue 228 type sequence A description BINDING SITE FOR RESIDUE PO4 C 361 source : AC5 28) chain C residue 197 type sequence T description BINDING SITE FOR RESIDUE PO4 C 362 source : AC6 29) chain C residue 199 type sequence T description BINDING SITE FOR RESIDUE PO4 C 362 source : AC6 30) chain C residue 249 type sequence R description BINDING SITE FOR RESIDUE PO4 C 362 source : AC6 31) chain D residue 165 type sequence S description BINDING SITE FOR RESIDUE PO4 D 361 source : AC7 32) chain D residue 166 type sequence C description BINDING SITE FOR RESIDUE PO4 D 361 source : AC7 33) chain D residue 167 type sequence T description BINDING SITE FOR RESIDUE PO4 D 361 source : AC7 34) chain D residue 226 type sequence T description BINDING SITE FOR RESIDUE PO4 D 361 source : AC7 35) chain D residue 227 type sequence G description BINDING SITE FOR RESIDUE PO4 D 361 source : AC7 36) chain D residue 228 type sequence A description BINDING SITE FOR RESIDUE PO4 D 361 source : AC7 37) chain D residue 197 type sequence T description BINDING SITE FOR RESIDUE PO4 D 362 source : AC8 38) chain D residue 199 type sequence T description BINDING SITE FOR RESIDUE PO4 D 362 source : AC8 39) chain D residue 249 type sequence R description BINDING SITE FOR RESIDUE PO4 D 362 source : AC8 40) chain A residue 8 type sequence N description BINDING SITE FOR RESIDUE NAD A 363 source : AC9 41) chain A residue 9 type sequence G description BINDING SITE FOR RESIDUE NAD A 363 source : AC9 42) chain A residue 11 type sequence G description BINDING SITE FOR RESIDUE NAD A 363 source : AC9 43) chain A residue 12 type sequence R description BINDING SITE FOR RESIDUE NAD A 363 source : AC9 44) chain A residue 13 type sequence I description BINDING SITE FOR RESIDUE NAD A 363 source : AC9 45) chain A residue 37 type sequence V description BINDING SITE FOR RESIDUE NAD A 363 source : AC9 46) chain A residue 38 type sequence D description BINDING SITE FOR RESIDUE NAD A 363 source : AC9 47) chain A residue 39 type sequence M description BINDING SITE FOR RESIDUE NAD A 363 source : AC9 48) chain A residue 90 type sequence A description BINDING SITE FOR RESIDUE NAD A 363 source : AC9 49) chain A residue 91 type sequence Q description BINDING SITE FOR RESIDUE NAD A 363 source : AC9 50) chain A residue 110 type sequence S description BINDING SITE FOR RESIDUE NAD A 363 source : AC9 51) chain A residue 111 type sequence T description BINDING SITE FOR RESIDUE NAD A 363 source : AC9 52) chain A residue 112 type sequence G description BINDING SITE FOR RESIDUE NAD A 363 source : AC9 53) chain A residue 113 type sequence L description BINDING SITE FOR RESIDUE NAD A 363 source : AC9 54) chain A residue 134 type sequence S description BINDING SITE FOR RESIDUE NAD A 363 source : AC9 55) chain A residue 135 type sequence A description BINDING SITE FOR RESIDUE NAD A 363 source : AC9 56) chain A residue 166 type sequence C description BINDING SITE FOR RESIDUE NAD A 363 source : AC9 57) chain A residue 197 type sequence T description BINDING SITE FOR RESIDUE NAD A 363 source : AC9 58) chain A residue 198 type sequence A description BINDING SITE FOR RESIDUE NAD A 363 source : AC9 59) chain A residue 335 type sequence N description BINDING SITE FOR RESIDUE NAD A 363 source : AC9 60) chain A residue 336 type sequence E description BINDING SITE FOR RESIDUE NAD A 363 source : AC9 61) chain A residue 339 type sequence Y description BINDING SITE FOR RESIDUE NAD A 363 source : AC9 62) chain B residue 8 type sequence N description BINDING SITE FOR RESIDUE NAD B 363 source : BC1 63) chain B residue 9 type sequence G description BINDING SITE FOR RESIDUE NAD B 363 source : BC1 64) chain B residue 11 type sequence G description BINDING SITE FOR RESIDUE NAD B 363 source : BC1 65) chain B residue 12 type sequence R description BINDING SITE FOR RESIDUE NAD B 363 source : BC1 66) chain B residue 13 type sequence I description BINDING SITE FOR RESIDUE NAD B 363 source : BC1 67) chain B residue 37 type sequence V description BINDING SITE FOR RESIDUE NAD B 363 source : BC1 68) chain B residue 38 type sequence D description BINDING SITE FOR RESIDUE NAD B 363 source : BC1 69) chain B residue 39 type sequence M description BINDING SITE FOR RESIDUE NAD B 363 source : BC1 70) chain B residue 90 type sequence A description BINDING SITE FOR RESIDUE NAD B 363 source : BC1 71) chain B residue 110 type sequence S description BINDING SITE FOR RESIDUE NAD B 363 source : BC1 72) chain B residue 111 type sequence T description BINDING SITE FOR RESIDUE NAD B 363 source : BC1 73) chain B residue 113 type sequence L description BINDING SITE FOR RESIDUE NAD B 363 source : BC1 74) chain B residue 134 type sequence S description BINDING SITE FOR RESIDUE NAD B 363 source : BC1 75) chain B residue 135 type sequence A description BINDING SITE FOR RESIDUE NAD B 363 source : BC1 76) chain B residue 166 type sequence C description BINDING SITE FOR RESIDUE NAD B 363 source : BC1 77) chain B residue 335 type sequence N description BINDING SITE FOR RESIDUE NAD B 363 source : BC1 78) chain C residue 8 type sequence N description BINDING SITE FOR RESIDUE NAD C 363 source : BC2 79) chain C residue 9 type sequence G description BINDING SITE FOR RESIDUE NAD C 363 source : BC2 80) chain C residue 10 type sequence F description BINDING SITE FOR RESIDUE NAD C 363 source : BC2 81) chain C residue 11 type sequence G description BINDING SITE FOR RESIDUE NAD C 363 source : BC2 82) chain C residue 12 type sequence R description BINDING SITE FOR RESIDUE NAD C 363 source : BC2 83) chain C residue 13 type sequence I description BINDING SITE FOR RESIDUE NAD C 363 source : BC2 84) chain C residue 37 type sequence V description BINDING SITE FOR RESIDUE NAD C 363 source : BC2 85) chain C residue 38 type sequence D description BINDING SITE FOR RESIDUE NAD C 363 source : BC2 86) chain C residue 91 type sequence Q description BINDING SITE FOR RESIDUE NAD C 363 source : BC2 87) chain C residue 110 type sequence S description BINDING SITE FOR RESIDUE NAD C 363 source : BC2 88) chain C residue 111 type sequence T description BINDING SITE FOR RESIDUE NAD C 363 source : BC2 89) chain C residue 112 type sequence G description BINDING SITE FOR RESIDUE NAD C 363 source : BC2 90) chain C residue 113 type sequence L description BINDING SITE FOR RESIDUE NAD C 363 source : BC2 91) chain C residue 134 type sequence S description BINDING SITE FOR RESIDUE NAD C 363 source : BC2 92) chain C residue 166 type sequence C description BINDING SITE FOR RESIDUE NAD C 363 source : BC2 93) chain C residue 335 type sequence N description BINDING SITE FOR RESIDUE NAD C 363 source : BC2 94) chain C residue 339 type sequence Y description BINDING SITE FOR RESIDUE NAD C 363 source : BC2 95) chain D residue 206 type sequence V description BINDING SITE FOR RESIDUE NAD C 363 source : BC2 96) chain D residue 8 type sequence N description BINDING SITE FOR RESIDUE NAD D 363 source : BC3 97) chain D residue 9 type sequence G description BINDING SITE FOR RESIDUE NAD D 363 source : BC3 98) chain D residue 11 type sequence G description BINDING SITE FOR RESIDUE NAD D 363 source : BC3 99) chain D residue 12 type sequence R description BINDING SITE FOR RESIDUE NAD D 363 source : BC3 100) chain D residue 13 type sequence I description BINDING SITE FOR RESIDUE NAD D 363 source : BC3 101) chain D residue 37 type sequence V description BINDING SITE FOR RESIDUE NAD D 363 source : BC3 102) chain D residue 38 type sequence D description BINDING SITE FOR RESIDUE NAD D 363 source : BC3 103) chain D residue 39 type sequence M description BINDING SITE FOR RESIDUE NAD D 363 source : BC3 104) chain D residue 90 type sequence A description BINDING SITE FOR RESIDUE NAD D 363 source : BC3 105) chain D residue 91 type sequence Q description BINDING SITE FOR RESIDUE NAD D 363 source : BC3 106) chain D residue 111 type sequence T description BINDING SITE FOR RESIDUE NAD D 363 source : BC3 107) chain D residue 112 type sequence G description BINDING SITE FOR RESIDUE NAD D 363 source : BC3 108) chain D residue 113 type sequence L description BINDING SITE FOR RESIDUE NAD D 363 source : BC3 109) chain D residue 134 type sequence S description BINDING SITE FOR RESIDUE NAD D 363 source : BC3 110) chain D residue 135 type sequence A description BINDING SITE FOR RESIDUE NAD D 363 source : BC3 111) chain D residue 166 type sequence C description BINDING SITE FOR RESIDUE NAD D 363 source : BC3 112) chain D residue 198 type sequence A description BINDING SITE FOR RESIDUE NAD D 363 source : BC3 113) chain D residue 335 type sequence N description BINDING SITE FOR RESIDUE NAD D 363 source : BC3 114) chain D residue 336 type sequence E description BINDING SITE FOR RESIDUE NAD D 363 source : BC3 115) chain D residue 339 type sequence Y description BINDING SITE FOR RESIDUE NAD D 363 source : BC3 116) chain A residue 167 type ACT_SITE sequence T description Nucleophile source Swiss-Prot : SWS_FT_FI1 117) chain B residue 167 type ACT_SITE sequence T description Nucleophile source Swiss-Prot : SWS_FT_FI1 118) chain C residue 167 type ACT_SITE sequence T description Nucleophile source Swiss-Prot : SWS_FT_FI1 119) chain D residue 167 type ACT_SITE sequence T description Nucleophile source Swiss-Prot : SWS_FT_FI1 120) chain A residue 13 type BINDING sequence I description BINDING => ECO:0000269|PubMed:7578111, ECO:0000269|PubMed:9571030 source Swiss-Prot : SWS_FT_FI2 121) chain B residue 336 type BINDING sequence E description BINDING => ECO:0000269|PubMed:7578111, ECO:0000269|PubMed:9571030 source Swiss-Prot : SWS_FT_FI2 122) chain C residue 13 type BINDING sequence I description BINDING => ECO:0000269|PubMed:7578111, ECO:0000269|PubMed:9571030 source Swiss-Prot : SWS_FT_FI2 123) chain C residue 39 type BINDING sequence M description BINDING => ECO:0000269|PubMed:7578111, ECO:0000269|PubMed:9571030 source Swiss-Prot : SWS_FT_FI2 124) chain C residue 92 type BINDING sequence R description BINDING => ECO:0000269|PubMed:7578111, ECO:0000269|PubMed:9571030 source Swiss-Prot : SWS_FT_FI2 125) chain C residue 135 type BINDING sequence A description BINDING => ECO:0000269|PubMed:7578111, ECO:0000269|PubMed:9571030 source Swiss-Prot : SWS_FT_FI2 126) chain C residue 336 type BINDING sequence E description BINDING => ECO:0000269|PubMed:7578111, ECO:0000269|PubMed:9571030 source Swiss-Prot : SWS_FT_FI2 127) chain D residue 13 type BINDING sequence I description BINDING => ECO:0000269|PubMed:7578111, ECO:0000269|PubMed:9571030 source Swiss-Prot : SWS_FT_FI2 128) chain D residue 39 type BINDING sequence M description BINDING => ECO:0000269|PubMed:7578111, ECO:0000269|PubMed:9571030 source Swiss-Prot : SWS_FT_FI2 129) chain D residue 92 type BINDING sequence R description BINDING => ECO:0000269|PubMed:7578111, ECO:0000269|PubMed:9571030 source Swiss-Prot : SWS_FT_FI2 130) chain D residue 135 type BINDING sequence A description BINDING => ECO:0000269|PubMed:7578111, ECO:0000269|PubMed:9571030 source Swiss-Prot : SWS_FT_FI2 131) chain A residue 39 type BINDING sequence M description BINDING => ECO:0000269|PubMed:7578111, ECO:0000269|PubMed:9571030 source Swiss-Prot : SWS_FT_FI2 132) chain D residue 336 type BINDING sequence E description BINDING => ECO:0000269|PubMed:7578111, ECO:0000269|PubMed:9571030 source Swiss-Prot : SWS_FT_FI2 133) chain A residue 92 type BINDING sequence R description BINDING => ECO:0000269|PubMed:7578111, ECO:0000269|PubMed:9571030 source Swiss-Prot : SWS_FT_FI2 134) chain A residue 135 type BINDING sequence A description BINDING => ECO:0000269|PubMed:7578111, ECO:0000269|PubMed:9571030 source Swiss-Prot : SWS_FT_FI2 135) chain A residue 336 type BINDING sequence E description BINDING => ECO:0000269|PubMed:7578111, ECO:0000269|PubMed:9571030 source Swiss-Prot : SWS_FT_FI2 136) chain B residue 13 type BINDING sequence I description BINDING => ECO:0000269|PubMed:7578111, ECO:0000269|PubMed:9571030 source Swiss-Prot : SWS_FT_FI2 137) chain B residue 39 type BINDING sequence M description BINDING => ECO:0000269|PubMed:7578111, ECO:0000269|PubMed:9571030 source Swiss-Prot : SWS_FT_FI2 138) chain B residue 92 type BINDING sequence R description BINDING => ECO:0000269|PubMed:7578111, ECO:0000269|PubMed:9571030 source Swiss-Prot : SWS_FT_FI2 139) chain B residue 135 type BINDING sequence A description BINDING => ECO:0000269|PubMed:7578111, ECO:0000269|PubMed:9571030 source Swiss-Prot : SWS_FT_FI2 140) chain A residue 166 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 141) chain C residue 198 type BINDING sequence A description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 142) chain C residue 227 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 143) chain C residue 250 type BINDING sequence V description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 144) chain D residue 166 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 145) chain D residue 198 type BINDING sequence A description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 146) chain D residue 227 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 147) chain D residue 250 type BINDING sequence V description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 148) chain A residue 198 type BINDING sequence A description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 149) chain A residue 227 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 150) chain A residue 250 type BINDING sequence V description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 151) chain B residue 166 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 152) chain B residue 198 type BINDING sequence A description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 153) chain B residue 227 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 154) chain B residue 250 type BINDING sequence V description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 155) chain C residue 166 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 156) chain A residue 195 type SITE sequence S description Activates thiol group during catalysis source Swiss-Prot : SWS_FT_FI4 157) chain B residue 195 type SITE sequence S description Activates thiol group during catalysis source Swiss-Prot : SWS_FT_FI4 158) chain C residue 195 type SITE sequence S description Activates thiol group during catalysis source Swiss-Prot : SWS_FT_FI4 159) chain D residue 195 type SITE sequence S description Activates thiol group during catalysis source Swiss-Prot : SWS_FT_FI4 160) chain A residue 164-171 type prosite sequence ASCTTNCL description GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL source prosite : PS00071

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