eF-site ID 1a6a-ABC
PDB Code 1a6a
Chain A, B, C

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Title THE STRUCTURE OF AN INTERMEDIATE IN CLASS II MHC MATURATION: CLIP BOUND TO HLA-DR3
Classification COMPLEX (TRANSMEMBRANE/GLYCOPROTEIN)
Compound HLA class II histocompatibility antigen, DR alpha chain
Source ORGANISM_COMMON: human; ORGANISM_SCIENTIFIC: Homo sapiens;
Sequence A:  HVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWR
LEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPITN
VPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWLRN
GKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDCR
VEHWGLDEPLLKHWEF
B:  PRFLEYSTSECHFFNGTERVRYLDRYFHNQEENVRFDSDV
GEFRAVTELGRPDAEYWNSQKDLLEQKRGRVDNYCRHNYG
VVESFTVQRRVHPKVTVYPSKTQPLQHHNLLVCSVSGFYP
GSIEVRWFRNGQEEKTGVVSTGLIHNGDWTFQTLVMLETV
PRSGEVYTCQVEHPSVTSPLTVEWRAR
C:  PVSKMRMATPLLMQA
Description


Functional site
1) chain B
residue 57
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI1
2) chain B
residue 61
type BINDING
sequence W
description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI1
3) chain B
residue 81
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI1
4) chain B
residue 82
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI1
5) chain B
residue 93
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI2
6) chain A
residue 52
type BINDING
sequence A
description BINDING => ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI2
7) chain A
residue 55
type SITE
sequence E
description Pathogen-derived peptide antigen => ECO:0000269|PubMed:23260142, ECO:0007744|PDB:4GBX
source Swiss-Prot : SWS_FT_FI5
8) chain A
residue 62
type SITE
sequence N
description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4GBX
source Swiss-Prot : SWS_FT_FI6
9) chain A
residue 69
type SITE
sequence N
description Pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX
source Swiss-Prot : SWS_FT_FI7
10) chain A
residue 76
type SITE
sequence R
description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX
source Swiss-Prot : SWS_FT_FI8
11) chain A
residue 78
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400
source Swiss-Prot : SWS_FT_FI9
12) chain A
residue 118
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400
source Swiss-Prot : SWS_FT_FI9
13) chain B
residue 19
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19303388, ECO:0000269|PubMed:24190431
source Swiss-Prot : SWS_FT_FI3
14) chain A
residue 53
type SITE
sequence S
description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819
source Swiss-Prot : SWS_FT_FI4
15) chain B
residue 171-177
type prosite
sequence YTCQVEH
description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCQVEH
source prosite : PS00290
16) chain A
residue 161-167
type prosite
sequence YDCRVEH
description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCQVEH
source prosite : PS00290

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