eF-site ID 1a5v-A PDB Code 1a5v Chain A click to enlarge Title ASV INTEGRASE CORE DOMAIN WITH HIV-1 INTEGRASE INHIBITOR Y3 AND MN CATION Classification HYDROLASE Compound INTEGRASE Source Rous sarcoma virus (strain Prague C) (RSV-PrC) (POL_RSVP) Sequence A:  GLGPLQIWQTDFTLEPRMAPRSWLAVTVDTASSAIVVTQH GRVTSVAAQHHWATAIAVLGRPKAIKTDNGSCFTSKSTRE WLARWGIAHTTGIPGNSQGQAMVERANRLLKDKIRVLAEG DGFMKRIPTSKQGELLAKAMYALNHF Description Functional site 1) chain A residue 64 type sequence D description ACTIVE SITE. source : ACT 2) chain A residue 121 type sequence D description ACTIVE SITE. source : ACT 3) chain A residue 157 type sequence E description ACTIVE SITE. source : ACT 4) chain A residue 64 type sequence D description BINDING SITE FOR RESIDUE MN A 2 source : AC1 5) chain A residue 121 type sequence D description BINDING SITE FOR RESIDUE MN A 2 source : AC1 6) chain A residue 62 type sequence Q description BINDING SITE FOR RESIDUE Y3 A 1 source : AC2 7) chain A residue 119 type sequence K description BINDING SITE FOR RESIDUE Y3 A 1 source : AC2 8) chain A residue 119 type sequence K description BINDING SITE FOR RESIDUE Y3 A 1 source : AC2 9) chain A residue 145 type sequence G description BINDING SITE FOR RESIDUE Y3 A 1 source : AC2 10) chain A residue 146 type sequence I description BINDING SITE FOR RESIDUE Y3 A 1 source : AC2 11) chain A residue 154 type sequence A description BINDING SITE FOR RESIDUE Y3 A 1 source : AC2 12) chain A residue 155 type sequence M description BINDING SITE FOR RESIDUE Y3 A 1 source : AC2 13) chain A residue 136 type SITE sequence A description Cleavage; by viral protease p15 => ECO:0000303|PubMed:15102858 source Swiss-Prot : SWS_FT_FI1 14) chain A residue 64 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00457, ECO:0000269|PubMed:8805516, ECO:0000269|PubMed:9218451 source Swiss-Prot : SWS_FT_FI2 15) chain A residue 121 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU00457, ECO:0000269|PubMed:8805516, ECO:0000269|PubMed:9218451 source Swiss-Prot : SWS_FT_FI2 16) chain A residue 157 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P03354, ECO:0000269|PubMed:8805516, ECO:0000269|PubMed:9218451 source Swiss-Prot : SWS_FT_FI3

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