eF-site ID 1a5g-H PDB Code 1a5g Chain H click to enlarge Title HUMAN THROMBIN COMPLEXED WITH NOVEL SYNTHETIC PEPTIDE MIMETIC INHIBITOR AND HIRUGEN Classification HYDROLASE/HYDROLASE INHIBITOR Compound ALPHA-THROMBIN (SMALL SUBUNIT) Source ORGANISM_COMMON: human; ORGANISM_SCIENTIFIC: Homo sapiens; Sequence H:  IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLT AAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISM LEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCL PDRETAASLLQAGYKGRVTGWGNLKEGQPSVLQVVNLPIV ERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGP FVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKK WIQKVIDQFG Description (1)  ALPHA-THROMBIN, HIRUGEN, MOL126, N-PHENETHYL-FORMAMIDE Functional site 1) chain H residue 57 type sequence H description ACTIVE SITE. source : CAT 2) chain H residue 102 type sequence D description ACTIVE SITE. source : CAT 3) chain H residue 195 type sequence S description ACTIVE SITE. source : CAT 4) chain H residue 221 type sequence D description BINDING SITE FOR RESIDUE NA H 391 source : AC1 5) chain H residue 224 type sequence K description BINDING SITE FOR RESIDUE NA H 391 source : AC1 6) chain H residue 169 type sequence K description BINDING SITE FOR RESIDUE NA H 392 source : AC2 7) chain H residue 172 type sequence T description BINDING SITE FOR RESIDUE NA H 392 source : AC2 8) chain H residue 204 type sequence P description BINDING SITE FOR RESIDUE NA H 392 source : AC2 9) chain H residue 40 type sequence L description BINDING SITE FOR RESIDUE 00L H 372 source : AC3 10) chain H residue 41 type sequence L description BINDING SITE FOR RESIDUE 00L H 372 source : AC3 11) chain H residue 57 type sequence H description BINDING SITE FOR RESIDUE 00L H 372 source : AC3 12) chain H residue 60 type sequence L description BINDING SITE FOR RESIDUE 00L H 372 source : AC3 13) chain H residue 60 type sequence L description BINDING SITE FOR RESIDUE 00L H 372 source : AC3 14) chain H residue 97 type sequence R description BINDING SITE FOR RESIDUE 00L H 372 source : AC3 15) chain H residue 189 type sequence D description BINDING SITE FOR RESIDUE 00L H 372 source : AC3 16) chain H residue 190 type sequence A description BINDING SITE FOR RESIDUE 00L H 372 source : AC3 17) chain H residue 191 type sequence C description BINDING SITE FOR RESIDUE 00L H 372 source : AC3 18) chain H residue 192 type sequence E description BINDING SITE FOR RESIDUE 00L H 372 source : AC3 19) chain H residue 193 type sequence G description BINDING SITE FOR RESIDUE 00L H 372 source : AC3 20) chain H residue 194 type sequence D description BINDING SITE FOR RESIDUE 00L H 372 source : AC3 21) chain H residue 195 type sequence S description BINDING SITE FOR RESIDUE 00L H 372 source : AC3 22) chain H residue 214 type sequence S description BINDING SITE FOR RESIDUE 00L H 372 source : AC3 23) chain H residue 215 type sequence W description BINDING SITE FOR RESIDUE 00L H 372 source : AC3 24) chain H residue 216 type sequence G description BINDING SITE FOR RESIDUE 00L H 372 source : AC3 25) chain H residue 219 type sequence G description BINDING SITE FOR RESIDUE 00L H 372 source : AC3 26) chain H residue 220 type sequence C description BINDING SITE FOR RESIDUE 00L H 372 source : AC3 27) chain H residue 226 type sequence G description BINDING SITE FOR RESIDUE 00L H 372 source : AC3 28) chain H residue 34 type sequence F description BINDING SITE FOR CHAIN I OF HIRUGEN source : AC4 29) chain H residue 36 type sequence K description BINDING SITE FOR CHAIN I OF HIRUGEN source : AC4 30) chain H residue 38 type sequence Q description BINDING SITE FOR CHAIN I OF HIRUGEN source : AC4 31) chain H residue 65 type sequence L description BINDING SITE FOR CHAIN I OF HIRUGEN source : AC4 32) chain H residue 73 type sequence R description BINDING SITE FOR CHAIN I OF HIRUGEN source : AC4 33) chain H residue 74 type sequence T description BINDING SITE FOR CHAIN I OF HIRUGEN source : AC4 34) chain H residue 75 type sequence R description BINDING SITE FOR CHAIN I OF HIRUGEN source : AC4 35) chain H residue 75 type sequence R description BINDING SITE FOR CHAIN I OF HIRUGEN source : AC4 36) chain H residue 76 type sequence Y description BINDING SITE FOR CHAIN I OF HIRUGEN source : AC4 37) chain H residue 81 type sequence K description BINDING SITE FOR CHAIN I OF HIRUGEN source : AC4 38) chain H residue 82 type sequence I description BINDING SITE FOR CHAIN I OF HIRUGEN source : AC4 39) chain H residue 153 type sequence S description BINDING SITE FOR CHAIN I OF HIRUGEN source : AC4 40) chain H residue 102 type MOD_RES sequence D description Sulfotyrosine => ECO:0000269|PubMed:3513162 source Swiss-Prot : SWS_FT_FI1 41) chain H residue 195 type MOD_RES sequence S description Sulfotyrosine => ECO:0000269|PubMed:3513162 source Swiss-Prot : SWS_FT_FI1 42) chain H residue 60 type CARBOHYD sequence L description N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:873923 source Swiss-Prot : SWS_FT_FI2 43) chain H residue 53-58 type prosite sequence LTAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC source prosite : PS00134 44) chain H residue 189-200 type prosite sequence DACEGDSGGPFV description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV source prosite : PS00135

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