eF-site ID 1a50-AB PDB Code 1a50 Chain A, B click to enlarge Title CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASE COMPLEXED WITH 5-FLUOROINDOLE PROPANOL PHOSPHATE Classification LYASE Compound TRYPTOPHAN SYNTHASE (ALPHA CHAIN) Source ORGANISM_SCIENTIFIC: Salmonella typhimurium; Sequence A:  ERYENLFAQLNDRREGAFVPFVTLGDPGIEQSLKIIDTLI DAGADALELGVPFSDPLADGPTIQNANLRAFAAGVTPAQC FEMLALIREKHPTIPIGLLMYANLVFNNGIDAFYARCEQV GVDSVLVADVPVEESAPFRQAALRHNIAPIFICPPNADDD LLRQVASYGRGYTYLLSRSGVTGAENHHLIEKLKEYHAAP ALQGFGISSPEQVSAAVRAGAAGAISGSAIVKIIEKNLAS PKQMLAELRSFVSAMKAASR B:  TTLLNPYFGEFGGMYVPQILMPALNQLEEAFVRAQKDPEF QAQFADLLKNYAGRPTALTKCQNITAGTRTTLYLKREDLL HGGAHKTNQVLGQALLAKRMGKSEIIAETGAGQHGVASAL ASALLGLKCRIYMGAKDVERQSPNVFRMRLMGAEVIPVHS GSATLKDACNEALRDWSGSYETAHYMLGTAAGPHPYPTIV REFQRMIGEETKAQILDKEGRLPDAVIACVGGGSNAIGMF ADFINDTSVGLIGVEPGGHGIETGEHGAPLKHGRVGIYFG MKAPMMQTADGQIEESYSISAGLDFPSVGPQHAYLNSIGR ADYVSITDDEALEAFKTLCRHEGIIPALESSHALAHALKM MREQPEKEQLLVVNLSGRGDKDIFTVHDIL Description Functional site 1) chain B residue 232 type sequence G description BINDING SITE FOR RESIDUE NA B 2000 source : AC1 2) chain B residue 306 type sequence F description BINDING SITE FOR RESIDUE NA B 2000 source : AC1 3) chain B residue 308 type sequence S description BINDING SITE FOR RESIDUE NA B 2000 source : AC1 4) chain B residue 86 type sequence H description BINDING SITE FOR RESIDUE PLP B 901 source : AC2 5) chain B residue 87 type sequence K description BINDING SITE FOR RESIDUE PLP B 901 source : AC2 6) chain B residue 114 type sequence Q description BINDING SITE FOR RESIDUE PLP B 901 source : AC2 7) chain B residue 190 type sequence T description BINDING SITE FOR RESIDUE PLP B 901 source : AC2 8) chain B residue 230 type sequence C description BINDING SITE FOR RESIDUE PLP B 901 source : AC2 9) chain B residue 232 type sequence G description BINDING SITE FOR RESIDUE PLP B 901 source : AC2 10) chain B residue 233 type sequence G description BINDING SITE FOR RESIDUE PLP B 901 source : AC2 11) chain B residue 234 type sequence G description BINDING SITE FOR RESIDUE PLP B 901 source : AC2 12) chain B residue 235 type sequence S description BINDING SITE FOR RESIDUE PLP B 901 source : AC2 13) chain B residue 236 type sequence N description BINDING SITE FOR RESIDUE PLP B 901 source : AC2 14) chain B residue 303 type sequence G description BINDING SITE FOR RESIDUE PLP B 901 source : AC2 15) chain B residue 350 type sequence E description BINDING SITE FOR RESIDUE PLP B 901 source : AC2 16) chain B residue 377 type sequence S description BINDING SITE FOR RESIDUE PLP B 901 source : AC2 17) chain B residue 378 type sequence G description BINDING SITE FOR RESIDUE PLP B 901 source : AC2 18) chain A residue 22 type sequence F description BINDING SITE FOR RESIDUE FIP A 270 source : AC3 19) chain A residue 60 type sequence D description BINDING SITE FOR RESIDUE FIP A 270 source : AC3 20) chain A residue 64 type sequence I description BINDING SITE FOR RESIDUE FIP A 270 source : AC3 21) chain A residue 153 type sequence I description BINDING SITE FOR RESIDUE FIP A 270 source : AC3 22) chain A residue 175 type sequence Y description BINDING SITE FOR RESIDUE FIP A 270 source : AC3 23) chain A residue 183 type sequence T description BINDING SITE FOR RESIDUE FIP A 270 source : AC3 24) chain A residue 184 type sequence G description BINDING SITE FOR RESIDUE FIP A 270 source : AC3 25) chain A residue 212 type sequence F description BINDING SITE FOR RESIDUE FIP A 270 source : AC3 26) chain A residue 213 type sequence G description BINDING SITE FOR RESIDUE FIP A 270 source : AC3 27) chain A residue 234 type sequence G description BINDING SITE FOR RESIDUE FIP A 270 source : AC3 28) chain A residue 235 type sequence S description BINDING SITE FOR RESIDUE FIP A 270 source : AC3 29) chain B residue 88 type MOD_RES sequence T description N6-(pyridoxal phosphate)lysine source Swiss-Prot : SWS_FT_FI1 30) chain A residue 60 type MOD_RES sequence D description N6-(pyridoxal phosphate)lysine source Swiss-Prot : SWS_FT_FI1 31) chain B residue 88 type catalytic sequence T description 383 source MCSA : MCSA1 32) chain B residue 378 type catalytic sequence G description 383 source MCSA : MCSA1 33) chain B residue 110 type catalytic sequence T description 383 source MCSA : MCSA1 34) chain B residue 190 type catalytic sequence T description 383 source MCSA : MCSA1 35) chain B residue 232 type catalytic sequence G description 383 source MCSA : MCSA1 36) chain B residue 233 type catalytic sequence G description 383 source MCSA : MCSA1 37) chain B residue 234 type catalytic sequence G description 383 source MCSA : MCSA1 38) chain B residue 235 type catalytic sequence S description 383 source MCSA : MCSA1 39) chain B residue 236 type catalytic sequence N description 383 source MCSA : MCSA1 40) chain B residue 351 type catalytic sequence S description 383 source MCSA : MCSA1 41) chain A residue 48-61 type prosite sequence LELGVPFSDPLADG description TRP_SYNTHASE_ALPHA Tryptophan synthase alpha chain signature. LELGvPFSDPLADG source prosite : PS00167 42) chain B residue 80-94 type prosite sequence LLHGGAHKTNQVLGQ description TRP_SYNTHASE_BETA Tryptophan synthase beta chain pyridoxal-phosphate attachment site. LlHgGAHKtNqvLgQ source prosite : PS00168

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