eF-site ID 1a4i-A
PDB Code 1a4i
Chain A

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Title HUMAN TETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE
Classification OXIDOREDUCTASE
Compound METHYLENETETRAHYDROFOLATE DEHYDROGENASE / METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE
Source Homo sapiens (Human) (C1TC_HUMAN)
Sequence A:  APAEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAIL
QVGNRDDSNLYINVKLKAAEEIGIKATHIKLPRTTTESEV
MKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPE
KDVDGLTSINAGRLARGDLNDCFIPCTPKGCLELIKETGV
PIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTAH
LDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINYK
VVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESA
KRFLE
Description


Functional site

1) chain A
residue 148
type
sequence T
description BINDING SITE FOR RESIDUE NDP A 302
source : AC1

2) chain A
residue 172
type
sequence G
description BINDING SITE FOR RESIDUE NDP A 302
source : AC1

3) chain A
residue 173
type
sequence R
description BINDING SITE FOR RESIDUE NDP A 302
source : AC1

4) chain A
residue 174
type
sequence S
description BINDING SITE FOR RESIDUE NDP A 302
source : AC1

5) chain A
residue 177
type
sequence V
description BINDING SITE FOR RESIDUE NDP A 302
source : AC1

6) chain A
residue 196
type
sequence H
description BINDING SITE FOR RESIDUE NDP A 302
source : AC1

7) chain A
residue 197
type
sequence S
description BINDING SITE FOR RESIDUE NDP A 302
source : AC1

8) chain A
residue 215
type
sequence A
description BINDING SITE FOR RESIDUE NDP A 302
source : AC1

9) chain A
residue 216
type
sequence T
description BINDING SITE FOR RESIDUE NDP A 302
source : AC1

10) chain A
residue 217
type
sequence G
description BINDING SITE FOR RESIDUE NDP A 302
source : AC1

11) chain A
residue 218
type
sequence Q
description BINDING SITE FOR RESIDUE NDP A 302
source : AC1

12) chain A
residue 236
type
sequence C
description BINDING SITE FOR RESIDUE NDP A 302
source : AC1

13) chain A
residue 237
type
sequence G
description BINDING SITE FOR RESIDUE NDP A 302
source : AC1

14) chain A
residue 238
type
sequence I
description BINDING SITE FOR RESIDUE NDP A 302
source : AC1

15) chain A
residue 276
type
sequence G
description BINDING SITE FOR RESIDUE NDP A 302
source : AC1

16) chain A
residue 57
type catalytic
sequence L
description 389
source MCSA : MCSA1

17) chain A
residue 101
type catalytic
sequence L
description 389
source MCSA : MCSA1

18) chain A
residue 126
type catalytic
sequence G
description 389
source MCSA : MCSA1

19) chain A
residue 50
type catalytic
sequence N
description 458
source MCSA : MCSA2

20) chain A
residue 57
type catalytic
sequence L
description 458
source MCSA : MCSA2

21) chain A
residue 101
type catalytic
sequence L
description 458
source MCSA : MCSA2

22) chain A
residue 2
type MOD_RES
sequence A
description N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
source Swiss-Prot : SWS_FT_FI4

23) chain A
residue 57
type ACT_SITE
sequence L
description ACT_SITE => ECO:0000269|PubMed:10828945
source Swiss-Prot : SWS_FT_FI1

24) chain A
residue 53
type BINDING
sequence I
description BINDING => ECO:0000269|PubMed:10828945, ECO:0007744|PDB:1DIA, ECO:0007744|PDB:1DIB
source Swiss-Prot : SWS_FT_FI2

25) chain A
residue 100
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:10828945, ECO:0007744|PDB:1DIA, ECO:0007744|PDB:1DIB
source Swiss-Prot : SWS_FT_FI2

26) chain A
residue 273
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:10828945, ECO:0007744|PDB:1DIA, ECO:0007744|PDB:1DIB
source Swiss-Prot : SWS_FT_FI2

27) chain A
residue 173
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:10828945, ECO:0000269|PubMed:9519408, ECO:0007744|PDB:1A4I, ECO:0007744|PDB:1DIA, ECO:0007744|PDB:1DIB, ECO:0007744|PDB:1DIG
source Swiss-Prot : SWS_FT_FI3

28) chain A
residue 198
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:10828945, ECO:0000269|PubMed:9519408, ECO:0007744|PDB:1A4I, ECO:0007744|PDB:1DIA, ECO:0007744|PDB:1DIB, ECO:0007744|PDB:1DIG
source Swiss-Prot : SWS_FT_FI3

29) chain A
residue 78-103
type prosite
sequence ESEVMKYITSLNEDSTVHGFLVQLPL
description THF_DHG_CYH_1 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1. EsEVMkyItsLNeDstvhgFLVQLPL
source prosite : PS00766

30) chain A
residue 272-280
type prosite
sequence PGGVGPMTV
description THF_DHG_CYH_2 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. PGGVGPMTV
source prosite : PS00767


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