eF-site ID 1a41-A PDB Code 1a41 Chain A click to enlarge Title TYPE 1-TOPOISOMERASE CATALYTIC FRAGMENT FROM VACCINIA VIRUS Classification ISOMERASE Compound TOPOISOMERASE I Source Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) (TOP1_VACCV) Sequence A:  NAKRDRIFVRVYNVMKRINCFINKNIKKSSTDSNYQLAVF MLMETMFFKENETVGLLTLKNKHIEISPDEIVIKFVGKDK VSHEFVVHKSNRLYKPLLKLTDDSSPEEFLFNKLSERKVY ECIKQFGIRIKDLRTYGVNYTFLYNFWTNVKSISPLPSPK KLIALTIKQTAEVVGHTPSISKRAYMATTILEMVKDKNFL DVVSKTTFDEFLSIVVDHVKS Description Functional site 1) chain A residue 84 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1 source : AC1 2) chain A residue 257 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1 source : AC1 3) chain A residue 268 type sequence S description BINDING SITE FOR RESIDUE SO4 A 1 source : AC1 4) chain A residue 270 type sequence S description BINDING SITE FOR RESIDUE SO4 A 1 source : AC1 5) chain A residue 271 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1 source : AC1 6) chain A residue 167 type catalytic sequence K description 232 source MCSA : MCSA1 7) chain A residue 223 type catalytic sequence R description 232 source MCSA : MCSA1 8) chain A residue 265 type catalytic sequence H description 232 source MCSA : MCSA1 9) chain A residue 274 type catalytic sequence Y description 232 source MCSA : MCSA1 10) chain A residue 168 type SITE sequence D description Involved in religation => ECO:0000250|UniProtKB:P32989 source Swiss-Prot : SWS_FT_FI2 11) chain A residue 261-279 type prosite sequence EVVGHTPSISKRAYMATTI description TOPO_IB_1 Topoisomerase (Topo) IB-type active site signature. EvvghtpSISKraYMattI source prosite : PS00176 12) chain A residue 274 type ACT_SITE sequence Y description O-(3'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01382, ECO:0000255|PROSITE-ProRule:PRU10130, ECO:0000269|PubMed:15755148 source Swiss-Prot : SWS_FT_FI1

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