eF-site ID 1a3o-D
PDB Code 1a3o
Chain D

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Title ARTIFICIAL MUTANT (ALPHA Y42H) OF DEOXY HEMOGLOBIN
Classification OXYGEN TRANSPORT
Compound HEMOGLOBIN (ALPHA CHAIN)
Source ORGANISM_COMMON: human; ORGANISM_SCIENTIFIC: Homo sapiens;
Sequence D:  HLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRF
FESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNL
KGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKE
FTPPVQAAYQKVVAGVANALAHKYH
Description


Functional site

1) chain D
residue 63
type
sequence H
description BINDING SITE FOR RESIDUE HEM D 147
source : AC4

2) chain D
residue 66
type
sequence K
description BINDING SITE FOR RESIDUE HEM D 147
source : AC4

3) chain D
residue 67
type
sequence V
description BINDING SITE FOR RESIDUE HEM D 147
source : AC4

4) chain D
residue 91
type
sequence L
description BINDING SITE FOR RESIDUE HEM D 147
source : AC4

5) chain D
residue 92
type
sequence H
description BINDING SITE FOR RESIDUE HEM D 147
source : AC4

6) chain D
residue 96
type
sequence L
description BINDING SITE FOR RESIDUE HEM D 147
source : AC4

7) chain D
residue 102
type
sequence N
description BINDING SITE FOR RESIDUE HEM D 147
source : AC4

8) chain D
residue 103
type
sequence F
description BINDING SITE FOR RESIDUE HEM D 147
source : AC4

9) chain D
residue 141
type
sequence L
description BINDING SITE FOR RESIDUE HEM D 147
source : AC4

10) chain D
residue 94
type MOD_RES
sequence D
description S-nitrosocysteine => ECO:0000269|PubMed:8637569, ECO:0000269|PubMed:9843411
source Swiss-Prot : SWS_FT_FI10

11) chain D
residue 145
type MOD_RES
sequence Y
description N6-acetyllysine; alternate => ECO:0000269|PubMed:4531009
source Swiss-Prot : SWS_FT_FI11

12) chain D
residue 2
type CARBOHYD
sequence H
description N-linked (Glc) (glycation) valine; in Hb A1c => ECO:0000269|PubMed:635569
source Swiss-Prot : SWS_FT_FI12

13) chain D
residue 9
type CARBOHYD
sequence S
description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI13

14) chain D
residue 18
type CARBOHYD
sequence V
description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI13

15) chain D
residue 67
type CARBOHYD
sequence V
description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI13

16) chain D
residue 121
type CARBOHYD
sequence E
description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI13

17) chain D
residue 145
type CARBOHYD
sequence Y
description N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI14

18) chain D
residue 93
type BINDING
sequence C
description proximal binding residue
source Swiss-Prot : SWS_FT_FI3

19) chain D
residue 8
type SITE
sequence K
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4

20) chain D
residue 26
type SITE
sequence E
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4

21) chain D
residue 30
type SITE
sequence R
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4

22) chain D
residue 36
type SITE
sequence P
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4

23) chain D
residue 38
type SITE
sequence T
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4

24) chain D
residue 46
type SITE
sequence G
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4

25) chain D
residue 53
type SITE
sequence A
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4

26) chain D
residue 57
type SITE
sequence N
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4

27) chain D
residue 72
type SITE
sequence S
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4

28) chain D
residue 75
type SITE
sequence L
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4

29) chain D
residue 85
type SITE
sequence F
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4

30) chain D
residue 93
type SITE
sequence C
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4

31) chain D
residue 105
type SITE
sequence L
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4

32) chain D
residue 111
type SITE
sequence V
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4

33) chain D
residue 120
type SITE
sequence K
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4

34) chain D
residue 123
type SITE
sequence T
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4

35) chain D
residue 129
type SITE
sequence A
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4

36) chain D
residue 141
type SITE
sequence L
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4

37) chain D
residue 145
type SITE
sequence Y
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4

38) chain D
residue 60
type SITE
sequence V
description Not glycated => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI5

39) chain D
residue 83
type SITE
sequence G
description Not glycated => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI5

40) chain D
residue 96
type SITE
sequence L
description Not glycated => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI5

41) chain D
residue 2
type MOD_RES
sequence H
description N-pyruvate 2-iminyl-valine; in Hb A1b
source Swiss-Prot : SWS_FT_FI6

42) chain D
residue 10
type MOD_RES
sequence A
description Phosphoserine => ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI7

43) chain D
residue 45
type MOD_RES
sequence F
description Phosphoserine => ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI7

44) chain D
residue 13
type MOD_RES
sequence A
description Phosphothreonine => ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI8

45) chain D
residue 51
type MOD_RES
sequence P
description Phosphothreonine => ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI8

46) chain D
residue 88
type MOD_RES
sequence L
description Phosphothreonine => ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI8

47) chain D
residue 60
type MOD_RES
sequence V
description N6-acetyllysine => ECO:0000269|PubMed:4531009
source Swiss-Prot : SWS_FT_FI9

48) chain D
residue 83
type MOD_RES
sequence G
description N6-acetyllysine => ECO:0000269|PubMed:4531009
source Swiss-Prot : SWS_FT_FI9

49) chain D
residue 64
type BINDING
sequence G
description distal binding residue
source Swiss-Prot : SWS_FT_FI2

50) chain D
residue 2
type BINDING
sequence H
description
source Swiss-Prot : SWS_FT_FI1

51) chain D
residue 3
type BINDING
sequence L
description
source Swiss-Prot : SWS_FT_FI1

52) chain D
residue 83
type BINDING
sequence G
description
source Swiss-Prot : SWS_FT_FI1

53) chain D
residue 144
type BINDING
sequence K
description
source Swiss-Prot : SWS_FT_FI1


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