|
|
eF-site ID
|
1a36-ABC |
|
PDB Code
|
1a36 |
|
Chain
|
A, B, C |
|
click to enlarge
|
|
|
Title
|
TOPOISOMERASE I/DNA COMPLEX |
|
Classification
|
ISOMERASE/DNA |
|
Compound
|
DNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*A P*TP*TP*TP*TP*T)- 3') |
|
Source
|
Homo sapiens (Human) (1A36) |
|
|
Sequence
|
A: |
IKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAE
EVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNII
TNLSKCDFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKL
LKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLK
RRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLV
SWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCV
DKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKE
EGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDS
IRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILN
KHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPA
KILSYNRANRAVAILCNHQEKSMMNLQTKIDAKKEQLADA
RRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKL
EVQATDREENKQIALGTSKLNFLDPRITVAWCKKWGVPIE
KIYNKTQREKFAWAIDMADEDYEF
|
| B: |
AAAAAGACTTAGAAAAATTTTT
|
| C: |
AAAAATTTTTCTAAGTCTTTTT
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
724 |
| type |
ACT_SITE |
| sequence |
L
|
| description |
O-(3'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01382, ECO:0000255|PROSITE-ProRule:PRU10130, ECO:0000269|PubMed:10841763, ECO:0000269|PubMed:12426403, ECO:0000269|PubMed:12533542, ECO:0000269|PubMed:15165849, ECO:0000269|PubMed:15801827, ECO:0000269|PubMed:16033260, ECO:0000269|PubMed:9488644
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
A |
| residue |
317 |
| type |
SITE |
| sequence |
K
|
| description |
Interaction with DNA
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
3)
|
chain |
A |
| residue |
365 |
| type |
SITE |
| sequence |
G
|
| description |
Interaction with DNA
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
A |
| residue |
413 |
| type |
SITE |
| sequence |
L
|
| description |
Interaction with DNA
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
5)
|
chain |
A |
| residue |
444 |
| type |
SITE |
| sequence |
Y
|
| description |
Interaction with DNA
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
6)
|
chain |
A |
| residue |
502 |
| type |
SITE |
| sequence |
V
|
| description |
Interaction with DNA
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
7)
|
chain |
A |
| residue |
533 |
| type |
SITE |
| sequence |
D
|
| description |
Interaction with DNA
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
8)
|
chain |
A |
| residue |
575 |
| type |
SITE |
| sequence |
K
|
| description |
Interaction with DNA
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
9)
|
chain |
A |
| residue |
633 |
| type |
SITE |
| sequence |
Q
|
| description |
Interaction with DNA
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
10)
|
chain |
A |
| residue |
651 |
| type |
SITE |
| sequence |
I
|
| description |
Interaction with DNA
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
11)
|
chain |
A |
| residue |
281 |
| type |
MOD_RES |
| sequence |
D
|
| description |
N6-acetyllysine => ECO:0007744|PubMed:19608861
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
12)
|
chain |
A |
| residue |
507 |
| type |
MOD_RES |
| sequence |
L
|
| description |
Phosphoserine; by CK2 => ECO:0000269|PubMed:23185622
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
13)
|
chain |
A |
| residue |
550 |
| type |
CROSSLNK |
| sequence |
N
|
| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
14)
|
chain |
A |
| residue |
643 |
| type |
CROSSLNK |
| sequence |
S
|
| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
15)
|
chain |
A |
| residue |
701 |
| type |
CROSSLNK |
| sequence |
L
|
| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
16)
|
chain |
A |
| residue |
713 |
| type |
CROSSLNK |
| sequence |
Q
|
| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
17)
|
chain |
A |
| residue |
337 |
| type |
CROSSLNK |
| sequence |
E
|
| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
|