|
eF-site ID
|
1a31-ACD |
PDB Code
|
1a31 |
Chain
|
A, C, D |
|
click to enlarge
|
|
Title
|
HUMAN RECONSTITUTED DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX |
Classification
|
ISOMERASE/DNA |
Compound
|
DNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*5IUP*5IU*TP*GP*AP*AP*AP*AP*AP*5IUP*5IUP*5IUP*5IUP*T)-3') |
Source
|
Homo sapiens (Human) (1A31) |
|
Sequence
|
A: |
IKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAE
EVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNII
TNLSKCDFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKL
LKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLK
RRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLV
SWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCV
DKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKE
EGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDS
IRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILN
KHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPA
KILSYNRANRAVKLNXLDPRITVAWCKKWGVPIEKIYNKT
QREKFAWAIDMADEDYEF
|
C: |
AAAAAGACXXTGAAAAAXXXXT
|
D: |
AAAAATXXXXCAAAGTCTTTTT
|
|
Description
|
(1) |
TOPOISOMERASE I (E.C.5.99.1.2)/DNA COMPLEX
|
|
Functional site
|
|
1)
|
chain |
A |
residue |
723 |
type |
ACT_SITE |
sequence |
X
|
description |
O-(3'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01382, ECO:0000255|PROSITE-ProRule:PRU10130, ECO:0000269|PubMed:10841763, ECO:0000269|PubMed:12426403, ECO:0000269|PubMed:12533542, ECO:0000269|PubMed:15165849, ECO:0000269|PubMed:15801827, ECO:0000269|PubMed:16033260, ECO:0000269|PubMed:9488644
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
2)
|
chain |
A |
residue |
316 |
type |
SITE |
sequence |
R
|
description |
Interaction with DNA
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
3)
|
chain |
A |
residue |
364 |
type |
SITE |
sequence |
R
|
description |
Interaction with DNA
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
4)
|
chain |
A |
residue |
412 |
type |
SITE |
sequence |
W
|
description |
Interaction with DNA
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
5)
|
chain |
A |
residue |
443 |
type |
SITE |
sequence |
K
|
description |
Interaction with DNA
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
6)
|
chain |
A |
residue |
501 |
type |
SITE |
sequence |
T
|
description |
Interaction with DNA
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
7)
|
chain |
A |
residue |
532 |
type |
SITE |
sequence |
K
|
description |
Interaction with DNA
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
8)
|
chain |
A |
residue |
574 |
type |
SITE |
sequence |
N
|
description |
Interaction with DNA
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
9)
|
chain |
A |
residue |
280 |
type |
MOD_RES |
sequence |
K
|
description |
N6-acetyllysine => ECO:0007744|PubMed:19608861
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
10)
|
chain |
A |
residue |
506 |
type |
MOD_RES |
sequence |
S
|
description |
Phosphoserine; by CK2 => ECO:0000269|PubMed:23185622
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
11)
|
chain |
A |
residue |
549 |
type |
CROSSLNK |
sequence |
K
|
description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
|
source |
Swiss-Prot : SWS_FT_FI5
|
|
12)
|
chain |
A |
residue |
336 |
type |
CROSSLNK |
sequence |
K
|
description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733
|
source |
Swiss-Prot : SWS_FT_FI6
|
|
|
|