eF-site ID 1a27-A PDB Code 1a27 Chain A click to enlarge Title HUMAN 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 C-TERMINAL DELETION MUTANT COMPLEXED WITH ESTRADIOL AND NADP+ Classification DEHYDROGENASE Compound 17-BETA-HYDROXYSTEROID-DEHYDROGENASE Source null (DHB1_HUMAN) Sequence A:  ARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLK TQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVT EGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVR MLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKF ALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSP EEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEVF LTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMH REVFG Description Functional site 1) chain A residue 142 type sequence S description CATALYTIC SITE. source : CAT 2) chain A residue 155 type sequence Y description CATALYTIC SITE. source : CAT 3) chain A residue 159 type sequence K description CATALYTIC SITE. source : CAT 4) chain A residue 142 type sequence S description BINDING SITE FOR RESIDUE EST A 350 source : AC1 5) chain A residue 143 type sequence V description BINDING SITE FOR RESIDUE EST A 350 source : AC1 6) chain A residue 144 type sequence G description BINDING SITE FOR RESIDUE EST A 350 source : AC1 7) chain A residue 147 type sequence M description BINDING SITE FOR RESIDUE EST A 350 source : AC1 8) chain A residue 149 type sequence L description BINDING SITE FOR RESIDUE EST A 350 source : AC1 9) chain A residue 155 type sequence Y description BINDING SITE FOR RESIDUE EST A 350 source : AC1 10) chain A residue 193 type sequence M description BINDING SITE FOR RESIDUE EST A 350 source : AC1 11) chain A residue 225 type sequence V description BINDING SITE FOR RESIDUE EST A 350 source : AC1 12) chain A residue 259 type sequence F description BINDING SITE FOR RESIDUE EST A 350 source : AC1 13) chain A residue 279 type sequence M description BINDING SITE FOR RESIDUE EST A 350 source : AC1 14) chain A residue 9 type sequence G description BINDING SITE FOR RESIDUE NAP A 360 source : AC2 15) chain A residue 11 type sequence S description BINDING SITE FOR RESIDUE NAP A 360 source : AC2 16) chain A residue 12 type sequence S description BINDING SITE FOR RESIDUE NAP A 360 source : AC2 17) chain A residue 13 type sequence G description BINDING SITE FOR RESIDUE NAP A 360 source : AC2 18) chain A residue 14 type sequence I description BINDING SITE FOR RESIDUE NAP A 360 source : AC2 19) chain A residue 37 type sequence R description BINDING SITE FOR RESIDUE NAP A 360 source : AC2 20) chain A residue 64 type sequence L description BINDING SITE FOR RESIDUE NAP A 360 source : AC2 21) chain A residue 65 type sequence D description BINDING SITE FOR RESIDUE NAP A 360 source : AC2 22) chain A residue 66 type sequence V description BINDING SITE FOR RESIDUE NAP A 360 source : AC2 23) chain A residue 67 type sequence R description BINDING SITE FOR RESIDUE NAP A 360 source : AC2 24) chain A residue 90 type sequence N description BINDING SITE FOR RESIDUE NAP A 360 source : AC2 25) chain A residue 91 type sequence A description BINDING SITE FOR RESIDUE NAP A 360 source : AC2 26) chain A residue 92 type sequence G description BINDING SITE FOR RESIDUE NAP A 360 source : AC2 27) chain A residue 140 type sequence T description BINDING SITE FOR RESIDUE NAP A 360 source : AC2 28) chain A residue 141 type sequence G description BINDING SITE FOR RESIDUE NAP A 360 source : AC2 29) chain A residue 142 type sequence S description BINDING SITE FOR RESIDUE NAP A 360 source : AC2 30) chain A residue 155 type sequence Y description BINDING SITE FOR RESIDUE NAP A 360 source : AC2 31) chain A residue 159 type sequence K description BINDING SITE FOR RESIDUE NAP A 360 source : AC2 32) chain A residue 185 type sequence C description BINDING SITE FOR RESIDUE NAP A 360 source : AC2 33) chain A residue 186 type sequence G description BINDING SITE FOR RESIDUE NAP A 360 source : AC2 34) chain A residue 187 type sequence P description BINDING SITE FOR RESIDUE NAP A 360 source : AC2 35) chain A residue 188 type sequence V description BINDING SITE FOR RESIDUE NAP A 360 source : AC2 36) chain A residue 190 type sequence T description BINDING SITE FOR RESIDUE NAP A 360 source : AC2 37) chain A residue 192 type sequence F description BINDING SITE FOR RESIDUE NAP A 360 source : AC2 38) chain A residue 195 type sequence K description BINDING SITE FOR RESIDUE NAP A 360 source : AC2 39) chain A residue 156 type ACT_SITE sequence C description Proton acceptor source Swiss-Prot : SWS_FT_FI1 40) chain A residue 135 type MOD_RES sequence G description Phosphoserine; by PKA => ECO:0000269|PubMed:8994190 source Swiss-Prot : SWS_FT_FI3 41) chain A residue 142-170 type prosite sequence SVGGLMGLPFNDVYCASKFALEGLCESLA description ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvgglmglpfNdvYCASKFALeGLCeSLA source prosite : PS00061 42) chain A residue 10 type BINDING sequence C description BINDING => ECO:0000269|PubMed:8805577 source Swiss-Prot : SWS_FT_FI2 43) chain A residue 66 type BINDING sequence V description BINDING => ECO:0000269|PubMed:8805577 source Swiss-Prot : SWS_FT_FI2 44) chain A residue 143 type BINDING sequence V description BINDING => ECO:0000269|PubMed:8805577 source Swiss-Prot : SWS_FT_FI2 45) chain A residue 160 type BINDING sequence F description BINDING => ECO:0000269|PubMed:8805577 source Swiss-Prot : SWS_FT_FI2

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