eF-site ID 1a0j-ABCD PDB Code 1a0j Chain A, B, C, D click to enlarge Title CRYSTAL STRUCTURE OF A NON-PSYCHROPHILIC TRYPSIN FROM A COLD-ADAPTED FISH SPECIES. Classification SERINE PROTEASE Compound TRYPSIN Source ORGANISM_COMMON: Atlantic salmon; ORGANISM_SCIENTIFIC: Salmo salar; Sequence A:  IVGGYECRKNSASYQASLQSGYHFCGGSLISSTWVVSAAH CYKSRIQVRLGEHNIAVNEGTEQFIDSVKVIMHPSYNSRN LDNDIMLIKLSKPASLNSYVSTVALPSSCASSGTRCLVSG WGNLSGSSSNYPDTLRCLDLPILSSSSCNSAYPGQITSNM FCAGFMEGGKDSCQGDSGGPVVCNGQLQGVVSWGYGCAQR NKPGVYTKVCNYRSWISSTMSSN B:  IVGGYECRKNSASYQASLQSGYHFCGGSLISSTWVVSAAH CYKSRIQVRLGEHNIAVNEGTEQFIDSVKVIMHPSYNSRN LDNDIMLIKLSKPASLNSYVSTVALPSSCASSGTRCLVSG WGNLSGSSSNYPDTLRCLDLPILSSSSCNSAYPGQITSNM FCAGFMEGGKDSCQGDSGGPVVCNGQLQGVVSWGYGCAQR NKPGVYTKVCNYRSWISSTMSSN C:  IVGGYECRKNSASYQASLQSGYHFCGGSLISSTWVVSAAH CYKSRIQVRLGEHNIAVNEGTEQFIDSVKVIMHPSYNSRN LDNDIMLIKLSKPASLNSYVSTVALPSSCASSGTRCLVSG WGNLSGSSSNYPDTLRCLDLPILSSSSCNSAYPGQITSNM FCAGFMEGGKDSCQGDSGGPVVCNGQLQGVVSWGYGCAQR NKPGVYTKVCNYRSWISSTMSSN D:  IVGGYECRKNSASYQASLQSGYHFCGGSLISSTWVVSAAH CYKSRIQVRLGEHNIAVNEGTEQFIDSVKVIMHPSYNSRN LDNDIMLIKLSKPASLNSYVSTVALPSSCASSGTRCLVSG WGNLSGSSSNYPDTLRCLDLPILSSSSCNSAYPGQITSNM FCAGFMEGGKDSCQGDSGGPVVCNGQLQGVVSWGYGCAQR NKPGVYTKVCNYRSWISSTMSSN Description Functional site 1) chain A residue 70 type sequence E description BINDING SITE FOR RESIDUE CA A 247 source : AC1 2) chain A residue 72 type sequence N description BINDING SITE FOR RESIDUE CA A 247 source : AC1 3) chain A residue 75 type sequence V description BINDING SITE FOR RESIDUE CA A 247 source : AC1 4) chain A residue 77 type sequence E description BINDING SITE FOR RESIDUE CA A 247 source : AC1 5) chain A residue 80 type sequence E description BINDING SITE FOR RESIDUE CA A 247 source : AC1 6) chain A residue 40 type sequence H description BINDING SITE FOR RESIDUE SO4 A 248 source : AC2 7) chain A residue 57 type sequence H description BINDING SITE FOR RESIDUE SO4 A 248 source : AC2 8) chain A residue 192 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 248 source : AC2 9) chain A residue 193 type sequence G description BINDING SITE FOR RESIDUE SO4 A 248 source : AC2 10) chain A residue 195 type sequence S description BINDING SITE FOR RESIDUE SO4 A 248 source : AC2 11) chain A residue 152 type sequence P description BINDING SITE FOR RESIDUE SO4 A 249 source : AC3 12) chain A residue 153 type sequence D description BINDING SITE FOR RESIDUE SO4 A 249 source : AC3 13) chain A residue 154 type sequence T description BINDING SITE FOR RESIDUE SO4 A 249 source : AC3 14) chain A residue 156 type sequence R description BINDING SITE FOR RESIDUE SO4 A 249 source : AC3 15) chain B residue 57 type sequence H description BINDING SITE FOR RESIDUE SO4 B 248 source : AC4 16) chain B residue 192 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 248 source : AC4 17) chain B residue 193 type sequence G description BINDING SITE FOR RESIDUE SO4 B 248 source : AC4 18) chain B residue 195 type sequence S description BINDING SITE FOR RESIDUE SO4 B 248 source : AC4 19) chain B residue 152 type sequence P description BINDING SITE FOR RESIDUE SO4 B 249 source : AC5 20) chain B residue 153 type sequence D description BINDING SITE FOR RESIDUE SO4 B 249 source : AC5 21) chain B residue 154 type sequence T description BINDING SITE FOR RESIDUE SO4 B 249 source : AC5 22) chain B residue 156 type sequence R description BINDING SITE FOR RESIDUE SO4 B 249 source : AC5 23) chain C residue 57 type sequence H description BINDING SITE FOR RESIDUE SO4 C 248 source : AC6 24) chain C residue 192 type sequence Q description BINDING SITE FOR RESIDUE SO4 C 248 source : AC6 25) chain C residue 193 type sequence G description BINDING SITE FOR RESIDUE SO4 C 248 source : AC6 26) chain C residue 195 type sequence S description BINDING SITE FOR RESIDUE SO4 C 248 source : AC6 27) chain C residue 21 type sequence E description BINDING SITE FOR RESIDUE SO4 C 249 source : AC7 28) chain C residue 152 type sequence P description BINDING SITE FOR RESIDUE SO4 C 249 source : AC7 29) chain C residue 153 type sequence D description BINDING SITE FOR RESIDUE SO4 C 249 source : AC7 30) chain C residue 154 type sequence T description BINDING SITE FOR RESIDUE SO4 C 249 source : AC7 31) chain C residue 156 type sequence R description BINDING SITE FOR RESIDUE SO4 C 249 source : AC7 32) chain A residue 39 type sequence Y description BINDING SITE FOR RESIDUE SO4 D 248 source : AC8 33) chain D residue 57 type sequence H description BINDING SITE FOR RESIDUE SO4 D 248 source : AC8 34) chain D residue 192 type sequence Q description BINDING SITE FOR RESIDUE SO4 D 248 source : AC8 35) chain D residue 193 type sequence G description BINDING SITE FOR RESIDUE SO4 D 248 source : AC8 36) chain D residue 195 type sequence S description BINDING SITE FOR RESIDUE SO4 D 248 source : AC8 37) chain A residue 76 type sequence N description BINDING SITE FOR RESIDUE SO4 D 249 source : AC9 38) chain B residue 235 type sequence R description BINDING SITE FOR RESIDUE SO4 D 249 source : AC9 39) chain D residue 152 type sequence P description BINDING SITE FOR RESIDUE SO4 D 249 source : AC9 40) chain D residue 153 type sequence D description BINDING SITE FOR RESIDUE SO4 D 249 source : AC9 41) chain D residue 154 type sequence T description BINDING SITE FOR RESIDUE SO4 D 249 source : AC9 42) chain D residue 156 type sequence R description BINDING SITE FOR RESIDUE SO4 D 249 source : AC9 43) chain A residue 148 type sequence S description BINDING SITE FOR RESIDUE SO4 D 250 source : BC1 44) chain A residue 149 type sequence S description BINDING SITE FOR RESIDUE SO4 D 250 source : BC1 45) chain C residue 95 type sequence N description BINDING SITE FOR RESIDUE SO4 D 250 source : BC1 46) chain C residue 97 type sequence R description BINDING SITE FOR RESIDUE SO4 D 250 source : BC1 47) chain D residue 62 type sequence R description BINDING SITE FOR RESIDUE SO4 D 250 source : BC1 48) chain C residue 96 type sequence S description BINDING SITE FOR RESIDUE SO4 D 251 source : BC2 49) chain D residue 60 type sequence K description BINDING SITE FOR RESIDUE SO4 D 251 source : BC2 50) chain D residue 61 type sequence S description BINDING SITE FOR RESIDUE SO4 D 251 source : BC2 51) chain A residue 189 type sequence D description BINDING SITE FOR RESIDUE BEN A 246 source : BC3 52) chain A residue 190 type sequence S description BINDING SITE FOR RESIDUE BEN A 246 source : BC3 53) chain A residue 195 type sequence S description BINDING SITE FOR RESIDUE BEN A 246 source : BC3 54) chain A residue 219 type sequence G description BINDING SITE FOR RESIDUE BEN A 246 source : BC3 55) chain A residue 220 type sequence C description BINDING SITE FOR RESIDUE BEN A 246 source : BC3 56) chain A residue 226 type sequence G description BINDING SITE FOR RESIDUE BEN A 246 source : BC3 57) chain B residue 189 type sequence D description BINDING SITE FOR RESIDUE BEN B 246 source : BC4 58) chain B residue 190 type sequence S description BINDING SITE FOR RESIDUE BEN B 246 source : BC4 59) chain B residue 195 type sequence S description BINDING SITE FOR RESIDUE BEN B 246 source : BC4 60) chain B residue 219 type sequence G description BINDING SITE FOR RESIDUE BEN B 246 source : BC4 61) chain B residue 226 type sequence G description BINDING SITE FOR RESIDUE BEN B 246 source : BC4 62) chain C residue 189 type sequence D description BINDING SITE FOR RESIDUE BEN C 246 source : BC5 63) chain C residue 190 type sequence S description BINDING SITE FOR RESIDUE BEN C 246 source : BC5 64) chain C residue 191 type sequence C description BINDING SITE FOR RESIDUE BEN C 246 source : BC5 65) chain C residue 195 type sequence S description BINDING SITE FOR RESIDUE BEN C 246 source : BC5 66) chain C residue 219 type sequence G description BINDING SITE FOR RESIDUE BEN C 246 source : BC5 67) chain C residue 226 type sequence G description BINDING SITE FOR RESIDUE BEN C 246 source : BC5 68) chain D residue 189 type sequence D description BINDING SITE FOR RESIDUE BEN D 246 source : BC6 69) chain D residue 190 type sequence S description BINDING SITE FOR RESIDUE BEN D 246 source : BC6 70) chain D residue 191 type sequence C description BINDING SITE FOR RESIDUE BEN D 246 source : BC6 71) chain D residue 195 type sequence S description BINDING SITE FOR RESIDUE BEN D 246 source : BC6 72) chain D residue 219 type sequence G description BINDING SITE FOR RESIDUE BEN D 246 source : BC6 73) chain D residue 226 type sequence G description BINDING SITE FOR RESIDUE BEN D 246 source : BC6 74) chain A residue 57 type ACT_SITE sequence H description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 75) chain D residue 57 type ACT_SITE sequence H description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 76) chain D residue 102 type ACT_SITE sequence D description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 77) chain D residue 195 type ACT_SITE sequence S description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 78) chain A residue 102 type ACT_SITE sequence D description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 79) chain A residue 195 type ACT_SITE sequence S description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 80) chain B residue 57 type ACT_SITE sequence H description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 81) chain B residue 102 type ACT_SITE sequence D description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 82) chain B residue 195 type ACT_SITE sequence S description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 83) chain C residue 57 type ACT_SITE sequence H description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 84) chain C residue 102 type ACT_SITE sequence D description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 85) chain C residue 195 type ACT_SITE sequence S description Charge relay system => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 86) chain A residue 70 type BINDING sequence E description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 87) chain D residue 70 type BINDING sequence E description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 88) chain D residue 72 type BINDING sequence N description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 89) chain D residue 80 type BINDING sequence E description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 90) chain A residue 72 type BINDING sequence N description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 91) chain A residue 80 type BINDING sequence E description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 92) chain B residue 70 type BINDING sequence E description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 93) chain B residue 72 type BINDING sequence N description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 94) chain B residue 80 type BINDING sequence E description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 95) chain C residue 70 type BINDING sequence E description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 96) chain C residue 72 type BINDING sequence N description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 97) chain C residue 80 type BINDING sequence E description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 98) chain A residue 75 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI3 99) chain B residue 75 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI3 100) chain C residue 75 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI3 101) chain D residue 75 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI3 102) chain A residue 189 type SITE sequence D description Required for specificity => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 103) chain B residue 189 type SITE sequence D description Required for specificity => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 104) chain C residue 189 type SITE sequence D description Required for specificity => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 105) chain D residue 189 type SITE sequence D description Required for specificity => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 106) chain A residue 53-58 type prosite sequence VSAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC source prosite : PS00134 107) chain A residue 189-200 type prosite sequence DSCQGDSGGPVV description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPVV source prosite : PS00135

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