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eF-site ID
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1a0h-ABDE |
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PDB Code
|
1a0h |
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Chain
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A, B, D, E |
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click to enlarge
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Title
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THE X-RAY CRYSTAL STRUCTURE OF PPACK-MEIZOTHROMBIN DESF1: KRINGLE/THROMBIN AND CARBOHYDRATE/KRINGLE/THROMBIN INTERACTIONS AND LOCATION OF THE LINKER CHAIN |
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Classification
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HYDROLASE/HYDROLASE INHIBITOR |
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Compound
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MEIZOTHROMBIN |
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Source
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ORGANISM_COMMON: cattle; ORGANISM_SCIENTIFIC: Bos taurus; |
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Sequence
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A: |
SPLLETCVPDRGREYRGRLAVTTHGSRCLAWSSEQAKALS
KDQDFNPAVPLAENFCRNPDGDEEGAWCYVADQPGDFEYC
DLNYCEEPVDGDLGDRLGEDPDPDAAIEGRTSEDHFQPFF
NEKTFGAGEADCGLRPLFEKKQVQDQTEKELFESYIEGR
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| B: |
IVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLT
AAHCLLYPPWDKNFTVDDLLVRIGKHSRTRYERKVEKISM
LDKIYIHPRYNWKENLDRDIALLKLKRPIELSDYIHPVCL
PDKQTAAKLLHAGFKGRVTGWGNRRETWTTSVAEVQPSVL
QVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDA
CEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFY
THVFRLKKWIQKVIDRLGS
|
| D: |
SPLLETCVPDRGREYRGRLAVTTHGSRCLAWSSEQAKALS
KDQDFNPAVPLAENFCRNPDGDEEGAWCYVADQPGDFEYC
DLNYCEEPVDGDLGDRLGEDPDPDAAIEGRTSEDHFQPFF
NEKTFGAGEADCGLRPLFEKKQVQDQTEKELFESYIEGR
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| E: |
IVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLT
AAHCLLYPPWDKNFTVDDLLVRIGKHSRTRYERKVEKISM
LDKIYIHPRYNWKENLDRDIALLKLKRPIELSDYIHPVCL
PDKQTAAKLLHAGFKGRVTGWGNRRETWTTSVAEVQPSVL
QVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDA
CEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFY
THVFRLKKWIQKVIDRLGS
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|
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Description
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Functional site
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|
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1)
|
chain |
B |
| residue |
373 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|Ref.4
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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2)
|
chain |
E |
| residue |
373 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|Ref.4
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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3)
|
chain |
B |
| residue |
359-364 |
| type |
prosite |
| sequence |
LTAAHC
|
| description |
TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC
|
| source |
prosite : PS00134
|
|
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4)
|
chain |
B |
| residue |
519-530 |
| type |
prosite |
| sequence |
DACEGDSGGPFV
|
| description |
TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV
|
| source |
prosite : PS00135
|
|
|
5)
|
chain |
A |
| residue |
218-231 |
| type |
prosite |
| sequence |
FCRNPDGDEEGAWC
|
| description |
KRINGLE_1 Kringle domain signature. FCRNpdgdeegaWC
|
| source |
prosite : PS00021
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|
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6)
|
chain |
B |
| residue |
363 |
| type |
ACT_SITE |
| sequence |
H
|
| description |
Charge relay system
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
7)
|
chain |
B |
| residue |
419 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Charge relay system
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
8)
|
chain |
B |
| residue |
525 |
| type |
ACT_SITE |
| sequence |
S
|
| description |
Charge relay system
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
9)
|
chain |
E |
| residue |
363 |
| type |
ACT_SITE |
| sequence |
H
|
| description |
Charge relay system
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
10)
|
chain |
E |
| residue |
419 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Charge relay system
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
11)
|
chain |
E |
| residue |
525 |
| type |
ACT_SITE |
| sequence |
S
|
| description |
Charge relay system
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|