eF-site ID 19gs-B PDB Code 19gs Chain B click to enlarge Title Glutathione s-transferase p1-1 Classification TRANSFERASE Compound GLUTATHIONE S-TRANSFERASE Source Homo sapiens (Human) (GSTP1_HUMAN) Sequence B:  PYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEG SLKASCLYGQLPKFQDGDLTLYQSNTILRHLGRTLGLYGK DQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYVKA LPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLI HEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYVNL PINGNGKQ Description Functional site 1) chain B residue 98 type sequence D description BINDING SITE FOR RESIDUE GSH A 211 source : AC2 2) chain B residue 171 type sequence D description BINDING SITE FOR RESIDUE MES A 212 source : AC3 3) chain B residue 35 type sequence V description BINDING SITE FOR RESIDUE BSP B 210 source : AC4 4) chain B residue 51 type sequence Q description BINDING SITE FOR RESIDUE BSP B 210 source : AC4 5) chain B residue 108 type sequence Y description BINDING SITE FOR RESIDUE BSP B 210 source : AC4 6) chain B residue 7 type sequence Y description BINDING SITE FOR RESIDUE GSH B 211 source : AC5 7) chain B residue 8 type sequence F description BINDING SITE FOR RESIDUE GSH B 211 source : AC5 8) chain B residue 13 type sequence R description BINDING SITE FOR RESIDUE GSH B 211 source : AC5 9) chain B residue 38 type sequence W description BINDING SITE FOR RESIDUE GSH B 211 source : AC5 10) chain B residue 44 type sequence K description BINDING SITE FOR RESIDUE GSH B 211 source : AC5 11) chain B residue 51 type sequence Q description BINDING SITE FOR RESIDUE GSH B 211 source : AC5 12) chain B residue 52 type sequence L description BINDING SITE FOR RESIDUE GSH B 211 source : AC5 13) chain B residue 64 type sequence Q description BINDING SITE FOR RESIDUE GSH B 211 source : AC5 14) chain B residue 65 type sequence S description BINDING SITE FOR RESIDUE GSH B 211 source : AC5 15) chain B residue 22 type sequence A description BINDING SITE FOR RESIDUE MES B 212 source : AC6 16) chain B residue 28 type sequence W description BINDING SITE FOR RESIDUE MES B 212 source : AC6 17) chain B residue 30 type sequence E description BINDING SITE FOR RESIDUE MES B 212 source : AC6 18) chain B residue 197 type sequence E description BINDING SITE FOR RESIDUE MES B 212 source : AC6 19) chain B residue 128 type MOD_RES sequence P description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI5 20) chain B residue 45 type BINDING sequence A description BINDING => ECO:0000269|PubMed:1522586, ECO:0000269|PubMed:19396894, ECO:0000269|PubMed:19808963, ECO:0000269|PubMed:9012673, ECO:0000269|PubMed:9245401, ECO:0000269|PubMed:9351803, ECO:0000269|PubMed:9398518 source Swiss-Prot : SWS_FT_FI1 21) chain B residue 52 type BINDING sequence L description BINDING => ECO:0000269|PubMed:1522586, ECO:0000269|PubMed:19396894, ECO:0000269|PubMed:19808963, ECO:0000269|PubMed:9012673, ECO:0000269|PubMed:9245401, ECO:0000269|PubMed:9351803, ECO:0000269|PubMed:9398518 source Swiss-Prot : SWS_FT_FI1 22) chain B residue 65 type BINDING sequence S description BINDING => ECO:0000269|PubMed:1522586, ECO:0000269|PubMed:19396894, ECO:0000269|PubMed:19808963, ECO:0000269|PubMed:9012673, ECO:0000269|PubMed:9245401, ECO:0000269|PubMed:9351803, ECO:0000269|PubMed:9398518 source Swiss-Prot : SWS_FT_FI1 23) chain B residue 8 type BINDING sequence F description BINDING => ECO:0000269|PubMed:1522586, ECO:0000269|PubMed:19396894, ECO:0000269|PubMed:19808963, ECO:0000269|PubMed:9012673, ECO:0000269|PubMed:9245401, ECO:0000269|PubMed:9351803, ECO:0000269|PubMed:9398518 source Swiss-Prot : SWS_FT_FI1 24) chain B residue 14 type BINDING sequence C description BINDING => ECO:0000269|PubMed:1522586, ECO:0000269|PubMed:19396894, ECO:0000269|PubMed:19808963, ECO:0000269|PubMed:9012673, ECO:0000269|PubMed:9245401, ECO:0000269|PubMed:9351803, ECO:0000269|PubMed:9398518 source Swiss-Prot : SWS_FT_FI1 25) chain B residue 39 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:1522586, ECO:0000269|PubMed:19396894, ECO:0000269|PubMed:19808963, ECO:0000269|PubMed:9012673, ECO:0000269|PubMed:9245401, ECO:0000269|PubMed:9351803, ECO:0000269|PubMed:9398518 source Swiss-Prot : SWS_FT_FI1 26) chain B residue 4 type MOD_RES sequence T description Phosphotyrosine; by EGFR => ECO:0000269|PubMed:19254954 source Swiss-Prot : SWS_FT_FI2 27) chain B residue 199 type MOD_RES sequence V description Phosphotyrosine; by EGFR => ECO:0000269|PubMed:19254954 source Swiss-Prot : SWS_FT_FI2 28) chain B residue 62 type MOD_RES sequence L description Phosphothreonine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI3 29) chain B residue 103 type MOD_RES sequence Y description N6-succinyllysine => ECO:0000250|UniProtKB:P19157 source Swiss-Prot : SWS_FT_FI4 30) chain B residue 116 type MOD_RES sequence D description N6-succinyllysine => ECO:0000250|UniProtKB:P19157 source Swiss-Prot : SWS_FT_FI4

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