|
|
eF-site ID
|
189l-A |
|
PDB Code
|
189l |
|
Chain
|
A |
|
click to enlarge
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Title
|
ENHANCEMENT OF PROTEIN STABILITY BY THE COMBINATION OF POINT MUTATIONS IN T4 LYSOZYME IS ADDITIVE |
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Classification
|
HYDROLASE (O-GLYCOSYL) |
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Compound
|
T4 LYSOZYME |
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Source
|
(LYS_BPT4) |
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Sequence
|
A: |
MNLFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPDLN
VAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILR
NPKLKPVYDSLDAVRRCALINMVFQMGETGVAGFTDSLRM
LQQKRWDEAAANLAKSRWYNQTPDRAKRVITTFRTGTWDA
YKNL
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Description
|
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Functional site
|
|
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1)
|
chain |
A |
| residue |
11 |
| type |
catalytic |
| sequence |
E
|
| description |
921
|
| source |
MCSA : MCSA1
|
|
|
2)
|
chain |
A |
| residue |
20 |
| type |
catalytic |
| sequence |
D
|
| description |
921
|
| source |
MCSA : MCSA1
|
|
|
3)
|
chain |
A |
| residue |
32 |
| type |
BINDING |
| sequence |
L
|
| description |
BINDING => ECO:0000269|PubMed:8266098
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
4)
|
chain |
A |
| residue |
104 |
| type |
BINDING |
| sequence |
F
|
| description |
BINDING => ECO:0000269|PubMed:8266098
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
5)
|
chain |
A |
| residue |
117 |
| type |
BINDING |
| sequence |
S
|
| description |
BINDING => ECO:0000303|PubMed:7831309
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
6)
|
chain |
A |
| residue |
132 |
| type |
BINDING |
| sequence |
N
|
| description |
BINDING => ECO:0000303|PubMed:7831309
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
7)
|
chain |
A |
| residue |
11 |
| type |
ACT_SITE |
| sequence |
E
|
| description |
Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
8)
|
chain |
A |
| residue |
20 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:1892846, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
|