eF-site ID 173d-AC
PDB Code 173d
Chain A, C

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Title MULTIPLE BINDING MODES OF ANTICANCER DRUG ACTINOMYCIN D: X-RAY, MOLECULAR MODELING, AND SPECTROSCOPIC STUDIES OF D(GAAGCTTC)2-ACTINOMYCIN D COMPLEXES AND ITS HOST DNA
Classification DNA/ANTIBIOTIC
Compound DNA (5'-D(*GP*AP*AP*GP*CP*TP*TP*C)-3')
Source ORGANISM_SCIENTIFIC: STREPTOMYCES ANTIBIOTICUS;
Sequence A:  GAAGCTTC
C:  TXPXXX
Description (1)  ACTINOMYCIN D/DNA Complex


Functional site

1) chain A
residue 4
type
ligand
sequence G
description BINDING SITE FOR CHAIN C OF ACTINOMYCIN D
source : AC1

2) chain A
residue 4
type
ligand
sequence G
description BINDING SITE FOR CHAIN C OF ACTINOMYCIN D
source : AC1

3) chain A
residue 5
type
ligand
sequence C
description BINDING SITE FOR CHAIN C OF ACTINOMYCIN D
source : AC1

4) chain A
residue 5
type
ligand
sequence C
description BINDING SITE FOR CHAIN C OF ACTINOMYCIN D
source : AC1

5) chain A
residue 6
type
ligand
sequence T
description BINDING SITE FOR CHAIN C OF ACTINOMYCIN D
source : AC1

6) chain A
residue 3-4
type binding
ligand MVA: N-METHYLVALINE
sequence AG
description N-METHYLVALINE binding site
source pdb_hetatom : MVA_173d_C_5

7) chain C
residue 1
type binding
ligand MVA: N-METHYLVALINE
sequence T
description N-METHYLVALINE binding site
source pdb_hetatom : MVA_173d_C_5

8) chain C
residue 3
type binding
ligand MVA: N-METHYLVALINE
sequence P
description N-METHYLVALINE binding site
source pdb_hetatom : MVA_173d_C_5

9) chain A
residue 4-5
type binding
ligand PXZ: 2-AMINO-1,9-DICARBONYL-4,6-DIMETHYL-10-DEHYDRO-PHENOXAZIN-3-ONE
sequence GC
description 2-AMINO-1,9-DICARBONYL-4,6-DIMETHYL-10-DEHYDRO-PHENOXAZIN-3-ONE binding site
source pdb_hetatom : PXZ_173d_C_6

10) chain C
residue 1
type binding
ligand PXZ: 2-AMINO-1,9-DICARBONYL-4,6-DIMETHYL-10-DEHYDRO-PHENOXAZIN-3-ONE
sequence T
description 2-AMINO-1,9-DICARBONYL-4,6-DIMETHYL-10-DEHYDRO-PHENOXAZIN-3-ONE binding site
source pdb_hetatom : PXZ_173d_C_6

11) chain C
residue 1
type binding
ligand DVA: D-VALINE
sequence T
description D-VALINE binding site
source pdb_hetatom : DVA_173d_C_2

12) chain C
residue 3
type binding
ligand DVA: D-VALINE
sequence P
description D-VALINE binding site
source pdb_hetatom : DVA_173d_C_2

13) chain C
residue 1
type binding
ligand SAR: SARCOSINE
sequence T
description SARCOSINE binding site
source pdb_hetatom : SAR_173d_C_4

14) chain C
residue 3
type binding
ligand SAR: SARCOSINE
sequence P
description SARCOSINE binding site
source pdb_hetatom : SAR_173d_C_4


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