Author results

2WBJ
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TCR COMPLEX
Descriptor:HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN, DRB1-15 BETA CHAIN, ...
Authors:Harkiolaki, M., Holmes, S.L., Svendsen, P., Gregersen, J.W., Jensen, L.T., McMahon, R., Friese, M.A., van Boxel, G., Etzensperger, R., Tzartos, J.S., Kranc, K., Sainsbury, S., Harlos, K., Mellins, E.D., Palace, J., Esiri, M.M., van der Merwe, P.A., Jones, E.Y., Fugger, L.
Deposit date:2009-03-02
Release date:2009-04-07
Last modified:2012-08-22
Method:X-RAY DIFFRACTION (3 Å)
Cite:T Cell-Mediated Autoimmune Disease due to Low-Affinity Crossreactivity to Common Microbial Peptides.
Immunity, 30, 2009
1NAM
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MURINE ALLOREACTIVE SCFV TCR-PEPTIDE-MHC CLASS I MOLECULE COMPLEX
Descriptor:BM3.3 T Cell Receptor alpha-Chain, BM3.3 T Cell Receptor beta-Chain, H-2 class I histocompatibility antigen, ...
Authors:Reiser, J.-B., Darnault, C., Gregoire, C., Mosser, T., Mazza, G., Kearnay, A., van der Merwe, P.A., Fontecilla-Camps, J.C., Housset, D., Malissen, B.
Deposit date:2002-11-28
Release date:2003-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:CDR3 loop flexibility contributes to the degeneracy of TCR recognition
Nat.Immunol., 4, 2003
1CCZ
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CRYSTAL STRUCTURE OF THE CD2-BINDING DOMAIN OF CD58 (LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN 3) AT 1.8-A RESOLUTION
Descriptor:PROTEIN (CD58), N-ACETYL-D-GLUCOSAMINE
Authors:Ikemizu, S., Sparks, L.M., Van Der Merwe, P.A., Harlos, K., Stuart, D.I., Jones, E.Y., Davis, S.J.
Deposit date:1999-03-02
Release date:1999-04-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the CD2-binding domain of CD58 (lymphocyte function-associated antigen 3) at 1.8-A resolution.
Proc.Natl.Acad.Sci.USA, 96, 1999
1ERG
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THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE EXTRACELLULAR REGION OF THE COMPLEMENT REGULATORY PROTEIN, CD59, A NEW CELL SURFACE PROTEIN DOMAIN RELATED TO NEUROTOXINS
Descriptor:CD59
Authors:Kieffer, B., Driscoll, P.C., Campbell, I.D., Willis, A.C., Van Der Merwe, P.A., Davis, S.J.
Deposit date:1993-12-13
Release date:1994-04-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins.
Biochemistry, 33, 1994
1ERH
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THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE EXTRACELLULAR REGION OF THE COMPLEMENT REGULATORY PROTEIN, CD59, A NEW CELL SURFACE PROTEIN DOMAIN RELATED TO NEUROTOXINS
Descriptor:CD59
Authors:Kieffer, B., Driscoll, P.C., Campbell, I.D., Willis, A.C., Van Der Merwe, P.A., Davis, S.J.
Deposit date:1993-12-13
Release date:1994-04-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins.
Biochemistry, 33, 1994
1NAN
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MCH CLASS I H-2KB MOLECULE COMPLEXED WITH PBM1 PEPTIDE
Descriptor:H-2 class I histocompatibility antigen, K-B alpha chain, Beta-2-microglobulin, ...
Authors:Reiser, J.-B., Darnault, C., Gregoire, C., Mosser, T., Mazza, G., Kearnay, A., van der Merwe, P.A., Fontecilla-Camps, J.C., Housset, D., Malissen, B.
Deposit date:2002-11-28
Release date:2003-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:CDR3 loop flexibility contributes to the degeneracy of TCR recognition
Nat.Immunol., 4, 2003
1T6W
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RATIONAL DESIGN OF A CALCIUM-BINDING ADHESION PROTEIN NMR, 20 STRUCTURES
Descriptor:hypothetical protein XP_346638, CALCIUM ION
Authors:Yang, W., Wilkins, A.L., Ye, Y., Liu, Z.-R., Urbauer, J.L., Kearney, A., van der Merwe, P.A., Yang, J.J.
Deposit date:2004-05-07
Release date:2005-02-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Design of a calcium-binding protein with desired structure in a cell adhesion molecule.
J.Am.Chem.Soc., 127, 2005
2BNQ
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STRUCTURAL AND KINETIC BASIS FOR HEIGHTENED IMMUNOGENICITY OF T CELL VACCINES
Descriptor:HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, BETA-2-MICROGLOBULIN, SYNTHETIC PEPTIDE, ...
Authors:Chen, J.-L., Stewart-Jones, G., Bossi, G., Lissin, N.M., Wooldridge, L., Choi, E.M.L., Held, G., Dunbar, P.R., Esnouf, R.M., Sami, M., Boultier, J.M., Rizkallah, P.J., Renner, C., Sewell, A., van der Merwe, P.A., Jackobsen, B.K., Griffiths, G., Jones, E.Y., Cerundolo, V.
Deposit date:2005-03-31
Release date:2005-05-23
Last modified:2015-11-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and Kinetic Basis for Heightened Immunogenicity of T Cell Vaccines
J.Exp.Med., 201, 2005
2BNR
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STRUCTURAL AND KINETIC BASIS FOR HEIGHTENED IMMUNOGENICITY OF T CELL VACCINES
Descriptor:HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, BETA-2-MICROGLOBULIN, SYNTHETIC PEPTIDE, ...
Authors:Chen, J.-L., Stewart-Jones, G., Bossi, G., Lissin, N.M., Wooldridge, L., Choi, E.M.L., Held, G., Dunbar, P.R., Esnouf, R.M., Sami, M., Boultier, J.M., Rizkallah, P.J., Renner, C., Sewell, A., van der Merwe, P.A., Jackobsen, B.K., Griffiths, G., Jones, E.Y., Cerundolo, V.
Deposit date:2005-03-31
Release date:2005-05-23
Last modified:2015-11-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Kinetic Basis for Heightened Immunogenicity of T Cell Vaccines
J.Exp.Med., 201, 2005
2BNU
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STRUCTURAL AND KINETIC BASIS FOR HEIGHTENED IMMUNOGENICITY OF T CELL VACCINES
Descriptor:T-CELL RECEPTOR ALPHA CHAIN C REGION, T-CELL RECEPTOR BETA CHAIN C REGION
Authors:Chen, J.-L., Stewart-Jones, G., Bossi, G., Lissin, N.M., Wooldridge, L., Choi, E.M.L., Held, G., Dunbar, P.R., Esnouf, R.M., Sami, M., Boultier, J.M., Rizkallah, P.J., Renner, C., Sewell, A., Van Der Merwe, P.A., Jackobsen, B.K., Griffiths, G., Jones, E.Y., Cerundolo, V.
Deposit date:2005-04-04
Release date:2005-05-24
Last modified:2015-11-25
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural and Kinetic Basis for Heightened Immunogenicity of T Cell Vaccines.
J.Exp.Med., 201, 2005
2C7U
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CONFLICTING SELECTIVE FORCES AFFECT CD8 T-CELL RECEPTOR CONTACT SITES IN AN HLA-A2 IMMUNODOMINANT HIV EPITOPE.
Descriptor:HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A-2 ALPHA CHAIN, BETA-2-MICROGLOBULIN, ...
Authors:Iversen, A.K., Stewart-Jones, G., Learn, G.H., Christie, N., Sylvester-Hviid, C., Armitage, A.E., Kaul, R., Beattie, T., Lee, J.K., Li, Y., Chotiyarnwong, P., Dong, T., Xu, X., Luscher, M.A., MacDonald, K., Ullum, H., Klarlund-Pedersen, B., Skinhoj, P., Fugger, J.L., Buus, S., Mullins, J.I., Jones, E.Y., van der Merwe, P.A., McMichael, A.J.
Deposit date:2005-11-29
Release date:2006-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Conflicting Selective Forces Affect T Cell Receptor Contacts in an Immunodominant Human Immunodeficiency Virus Epitope.
Nat.Immunol., 7, 2006
2C9A
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CRYSTAL STRUCTURE OF THE MAM-IG MODULE OF RECEPTOR PROTEIN TYROSINE PHOSPHATASE MU
Descriptor:RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE MU, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Aricescu, A.R., Hon, W.C., Siebold, C., Lu, W., Van Der Merwe, P.A., Jones, E.Y.
Deposit date:2005-12-09
Release date:2006-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular Analysis of Receptor Protein Tyrosine Phosphatase Mu-Mediated Cell Adhesion.
Embo J., 25, 2006
2OL3
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CRYSTAL STRUCTURE OF BM3.3 SCFV TCR IN COMPLEX WITH PBM8-H-2KBM8 MHC CLASS I MOLECULE
Descriptor:BM3.3 T-CELL RECEPTOR ALPHA-CHAIN, BM3.3 T-CELL RECEPTOR BETA-CHAIN, ALLOGENEIC H-2KBM8 MHC CLASS I MOLECULE, ...
Authors:Mazza, C., Auphan-Anezin, N., Gregoire, C., Guimezanes, A., Kellenberger, C., Roussel, A., Kearney, A., Van der Merwe, P.A., Schmitt-Verhulst, A.M., Malissen, B.
Deposit date:2007-01-18
Release date:2007-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:How much can a T-cell antigen receptor adapt to structurally distinct antigenic peptides?
Embo J., 26, 2007
2V2W
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T CELL CROSS-REACTIVITY AND CONFORMATIONAL CHANGES DURING TCR ENGAGEMENT
Descriptor:HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A-2 ALPHA CHAIN, BETA-2 MICROGLOBULIN, ...
Authors:Lee, J.K., Stewart-Jones, G., Dong, T., Harlos, K., Di Gleria, K., Dorrell, L., Douek, D.C., Van Der Merwe, P.A., Jones, E.Y., Mcmichael, A.J.
Deposit date:2007-06-07
Release date:2007-11-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:T Cell Cross-Reactivity and Conformational Changes During Tcr Engagement.
J.Exp.Med., 200, 2004
2V2X
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T CELL CROSS-REACTIVITY AND CONFORMATIONAL CHANGES DURING TCR ENGAGEMENT.
Descriptor:HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A-2 ALPHA CHAIN, BETA-2 MICROGLOBULIN, ...
Authors:Lee, J.K., Stewart-Jones, G., Dong, T., harlos, K., Di Gleria, K., Dorrell, L., Douek, D.C., van der Merwe, P.A., Jones, E.Y., McMichael, A.J.
Deposit date:2007-06-07
Release date:2007-11-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:T Cell Cross-Reactivity and Conformational Changes During Tcr Engagement.
J.Exp.Med., 200, 2004
2V5Y
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CRYSTAL STRUCTURE OF THE RECEPTOR PROTEIN TYROSINE PHOSPHATASE MU ECTODOMAIN
Descriptor:RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE MU, N-ACETYL-D-GLUCOSAMINE, SODIUM ION
Authors:Aricescu, A.R., Siebold, C., Choudhuri, K., Chang, V.T., Lu, W., Davis, S.J., van der Merwe, P.A., Jones, E.Y.
Deposit date:2007-07-11
Release date:2007-09-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of a Tyrosine Phosphatase Adhesive Interaction Reveals a Spacer-Clamp Mechanism.
Science, 317, 2007
2YPK
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STRUCTURAL FEATURES UNDERLYING T-CELL RECEPTOR SENSITIVITY TO CONCEALED MHC CLASS I MICROPOLYMORPHISMS
Descriptor:HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, B-57 ALPHA CHAIN, BETA-2-MICROGLOBULIN, ...
Authors:Stewart-Jones, G.B., Simpson, P., Van Der Merwe, P.A., Easterbrook, P., Mcmichael, A.J., Rowland-Jones, S.L., Jones, E.Y., Gillespie, G.M.
Deposit date:2012-10-30
Release date:2012-11-28
Last modified:2013-01-16
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Features Underlying T-Cell Receptor Sensitivity to Concealed Mhc Class I Micropolymorphisms.
Proc.Natl.Acad.Sci.USA, 109, 2012
2YPL
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STRUCTURAL FEATURES UNDERLYING T-CELL RECEPTOR SENSITIVITY TO CONCEALED MHC CLASS I MICROPOLYMORPHISMS
Descriptor:HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, B-57 ALPHA CHAIN, BETA-2-MICROGLOBULIN, ...
Authors:Stewart-Jones, G.B., Simpson, P., van der Merwe, P.A., Easterbrook, P., McMichael, A.J., Rowland-Jones, S.L., Jones, E.Y., Gillespie, G.M.
Deposit date:2012-10-30
Release date:2012-11-28
Last modified:2013-01-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Features Underlying T-Cell Receptor Sensitivity to Concealed Mhc Class I Micropolymorphisms.
Proc.Natl.Acad.Sci.USA, 109, 2012
2DRU
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CRYSTAL STRUCTURE AND BINDING PROPERTIES OF THE CD2 AND CD244 (2B4) BINDING PROTEIN, CD48
Descriptor:chimera of CD48 antigen and T-cell surface antigen CD2, N-ACETYL-D-GLUCOSAMINE, GLYCEROL
Authors:Evans, E.J., Ikemizu, S., Davis, S.J.
Deposit date:2006-06-15
Release date:2006-07-04
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure and Binding Properties of the CD2 and CD244 (2B4)-binding Protein, CD48
J.Biol.Chem., 281, 2006
3KLA
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CA2+ RELEASE FROM THE ENDOPLASMIC RETICULUM OF NY-ESO-1 SPECIFIC T CELLS IS MODULATED BY THE AFFINITY OF T CELL RECEPTOR AND BY THE USE OF THE CD8 CO-RECEPTOR
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Chen, J.L., Morgan, A.J., Stewart-Jones, G., Shepherd, D., Bossi, G., Wooldridge, L.
Deposit date:2009-11-07
Release date:2010-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Ca2+ Release from the Endoplasmic Reticulum of NY-ESO-1-Specific T Cells Is Modulated by the Affinity of TCR and by the Use of the CD8 Coreceptor.
J.Immunol., 184, 2010
1HNF
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR REGION OF THE HUMAN CELL ADHESION MOLECULE CD2 AT 2.5 ANGSTROMS RESOLUTION
Descriptor:CD2, N-ACETYL-D-GLUCOSAMINE, SODIUM ION
Authors:Bodian, D.L., Jones, E.Y., Harlos, K., Stuart, D.I., Davis, S.J.
Deposit date:1994-08-10
Release date:1995-02-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the extracellular region of the human cell adhesion molecule CD2 at 2.5 A resolution.
Structure, 2, 1994
1HNG
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CRYSTAL STRUCTURE AT 2.8 ANGSTROMS RESOLUTION OF A SOLUBLE FORM OF THE CELL ADHESION MOLECULE CD2
Descriptor:CD2
Authors:Jones, E.Y., Davis, S.J., Williams, A.F., Harlos, K., Stuart, D.I.
Deposit date:1994-08-10
Release date:1995-02-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure at 2.8 A resolution of a soluble form of the cell adhesion molecule CD2.
Nature, 360, 1992
2CLV
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MHC CLASS I NATURAL MUTANT H-2KBM8 HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND PBM8 PEPTIDE
Descriptor:H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, K-B ALPHA CHAIN, BETA-2 MICROGLOBULIN, ...
Authors:Mazza, C., Auphan-Anezin, N., Guimezanes, A., Barrett-Wilt, G.A., Montero-Julian, F., Roussel, A., Hunt, D.F., Schmitt-Verhulst, A.M., Malissen, B.
Deposit date:2006-05-02
Release date:2006-06-14
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Distinct orientation of the alloreactive monoclonal CD8 T cell activation program by three different peptide/MHC complexes.
Eur. J. Immunol., 36, 2006
2CLZ
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MHC CLASS I NATURAL MUTANT H-2KBM8 HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND PBM1 PEPTIDE
Descriptor:H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, K-B ALPHA CHAIN, BETA-2 MICROGLOBULIN, ...
Authors:Mazza, C., Auphan-Anezin, N., Guimezanes, A., Barrett-Wilt, G.A., Montero-Julian, F., Roussel, A., Hunt, D.F., Schmitt-Verhulst, A.M., Malissen, B.
Deposit date:2006-05-03
Release date:2006-06-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Distinct Orientation of the Alloreactive Monoclonal Cd8 T Cell Activation Program by Three Different Peptide/Mhc Complexes.
Eur.J.Immunol., 36, 2006