Author results

4INR
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YEAST 20S PROTEASOME IN COMPLEX WITH THE VINYL SULFONE LU102
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Geurink, P.P., van der Linden, W.A., Mirabella, A.C., Gallastegui, N., de Bruin, G., Blom, A.E.M., Voges, M.J., Mock, E.D., Florea, B.I., van der Marel, G.A., Driessen, C., van der Stelt, M., Groll, M., Overkleeft, H.S., Kisselev, A.F.
Deposit date:2013-01-06
Release date:2013-01-30
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites.
J.Med.Chem., 56, 2013
4INT
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YEAST 20S PROTEASOME IN COMPLEX WITH THE VINYL SULFONE LU122
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Geurink, P.P., van der Linden, W.A., Mirabella, A.C., Gallastegui, N., de Bruin, G., Blom, A.E.M., Voges, M.J., Mock, E.D., Florea, B.I., van der Marel, G.A., Driessen, C., van der Stelt, M., Groll, M., Overkleeft, H.S., Kisselev, A.F.
Deposit date:2013-01-06
Release date:2013-01-30
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites.
J.Med.Chem., 56, 2013
4INU
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YEAST 20S PROTEASOME IN COMPLEX WITH THE VINYL SULFONE LU112
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Geurink, P.P., van der Linden, W.A., Mirabella, A.C., Gallastegui, N., de Bruin, G., Blom, A.E.M., Voges, M.J., Mock, E.D., Florea, B.I., van der Marel, G.A., Driessen, C., van der Stelt, M., Groll, M., Overkleeft, H.S., Kisselev, A.F.
Deposit date:2013-01-06
Release date:2013-01-30
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites.
J.Med.Chem., 56, 2013
1NDN
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MOLECULAR STRUCTURE OF NICKED DNA. MODEL T4
Descriptor:DNA (5'-D(*CP*GP*CP*GP*AP*AP*AP*AP*CP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*GP*TP*T)-3'), DNA (5'-D(*TP*TP*CP*GP*CP*G)-3')
Authors:Aymani, J., Coll, M., Van Der Marel, G.A., Van Boom, J.H., Wang, A.H.-J., Rich, A.
Deposit date:1992-01-15
Release date:1992-07-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Molecular structure of nicked DNA: a substrate for DNA repair enzymes.
Proc.Natl.Acad.Sci.USA, 87, 1990
1VTE
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MOLECULAR STRUCTURE OF NICKED DNA. MODEL A4
Descriptor:DNA (5'-D(*CP*GP*CP*GP*AP*AP*AP*AP*CP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*GP*TP*T)-3'), DNA (5'-D(*TP*TP*CP*GP*CP*G)-3')
Authors:Aymani, J., Coll, M., Van Der Marel, G.A., Van Boom, J.H., Wang, A.H.-J., Rich, A.
Deposit date:1990-05-21
Release date:2011-07-13
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Molecular structure of nicked DNA: a substrate for DNA repair enzymes.
Proc. Natl. Acad. Sci. U.S.A., 87, 1990
1VTG
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THE MOLECULAR STRUCTURE OF A DNA-TRIOSTIN A COMPLEX
Descriptor:DNA (5'-D(*CP*GP*TP*AP*CP*G)-3'), triostin A, 2-CARBOXYQUINOXALINE
Authors:Wang, A.H.-J., Ughetto, G., Quigley, G.J., Hakoshima, T., Van Der Marel, G.A., Van Boom, J.H., Rich, A.
Deposit date:1988-08-18
Release date:2011-07-13
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:The molecular structure of a DNA-triostin A complex.
Science, 225, 1984
264D
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THREE-DIMENSIONAL CRYSTAL STRUCTURE OF THE A-TRACT DNA DODECAMER D(CGCAAATTTGCG) COMPLEXED WITH THE MINOR-GROOVE-BINDING DRUG HOECHST 33258
Descriptor:DNA (5'-D(*CP*GP*CP*AP*AP*AP*TP*TP*TP*GP*CP*G)-3'), 2'-(4-HYDROXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE
Authors:Vega, M.C., Garcia-Saez, I., Aymami, J., Eritja, R., Van Der Marel, G.A., Van Boom, J.H., Rich, A., Coll, M.
Deposit date:1994-09-22
Release date:1995-03-31
Last modified:2016-12-14
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Three-dimensional crystal structure of the A-tract DNA dodecamer d(CGCAAATTTGCG) complexed with the minor-groove-binding drug Hoechst 33258.
Eur.J.Biochem., 222, 1994
1AC7
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STRUCTURAL FEATURES OF THE DNA HAIRPIN D(ATCCTAGTTATAGGAT): THE FORMATION OF A G-A BASE PAIR IN THE LOOP, NMR, 10 STRUCTURES
Descriptor:DNA (5'-D(*AP*TP*CP*CP*TP*AP*GP*TP*TP*AP*TP*AP*GP*GP*AP*T)-3')
Authors:Van Dongen, M.J.P., Mooren, M.M.W., Willems, E.F.A., Van Der Marel, G.A., Van Boom, J.H., Wijmenga, S.S., Hilbers, C.W.
Deposit date:1997-02-14
Release date:1997-07-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural features of the DNA hairpin d(ATCCTA-GTTA-TAGGAT): formation of a G-A base pair in the loop.
Nucleic Acids Res., 25, 1997
1B4Y
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STRUCTURE AND MECHANISM OF FORMATION OF THE H-Y5 ISOMER OF AN INTRAMOLECULAR DNA TRIPLE HELIX.
Descriptor:DNA (H-Y5 TRIPLE HELIX)
Authors:Van Dongen, M.J.P., Doreleijers, J.F., Van Der Marel, G.A., Van Boom, J.H., Hilbers, C.W., Wijmenga, S.S.
Deposit date:1998-12-30
Release date:1999-09-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and mechanism of formation of the H-y5 isomer of an intramolecular DNA triple helix.
Nat.Struct.Biol., 6, 1999
1D96
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MOLECULAR STRUCTURE OF R(GCG)D(TATACGC): A DNA-RNA HYBRID HELIX JOINED TO DOUBLE HELICAL DNA
Descriptor:DNA/RNA (5'-R(*GP*CP*GP*)-D(*TP*AP*TP*AP*CP*GP*C)-3')
Authors:Wang, A.H.-J., Fujii, S., Van Boom, J.H., Van Der Marel, G.A., Van Boeckel, S.A.A., Rich, A.
Deposit date:1992-10-17
Release date:1993-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular structure of r(GCG)d(TATACGC): a DNA--RNA hybrid helix joined to double helical DNA.
Nature, 299, 1982
1UZ6
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ANTI-LEWIS X FAB FRAGMENT UNCOMPLEXED
Descriptor:IGG FAB (IGG3, KAPPA) LIGHT CHAIN 291-2G3-A, KAPPA) HEAVY CHAIN 291-2G3-A, ...
Authors:Van Roon, A.M.M., Pannu, N.S., De Vrind, J.P.M., Hokke, C.H., Deelder, A.M., Van Der marel, G.A., Van Boom, J.H., Abrahams, J.P.
Deposit date:2004-03-05
Release date:2004-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure of an Anti-Lewis X Fab Fragment in Complex with its Lewis X Antigen
Structure, 12, 2004
1UZ8
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ANTI-LEWIS X FAB FRAGMENT IN COMPLEX WITH LEWIS X
Descriptor:IGG FAB (IGG3, KAPPA) LIGHT CHAIN 291-2G3-A, KAPPA) HEAVY CHAIN 291-2G3-A, ...
Authors:Van Roon, A.M.M., Pannu, N.S., De Vrind, J.P.M., Hokke, C.H., Deelder, A.M., Van Der marel, G.A., Van Boom, J.H., Abrahams, J.P.
Deposit date:2004-03-05
Release date:2004-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of an Anti-Lewis X Fab Fragment in Complex with its Lewis X Antigen
Structure, 12, 2004
121D
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MOLECULAR STRUCTURE OF THE A-TRACT DNA DODECAMER D(CGCAAATTTGCG) COMPLEXED WITH THE MINOR GROOVE BINDING DRUG NETROPSIN
Descriptor:DNA (5'-D(*CP*GP*CP*AP*AP*AP*TP*TP*TP*GP*CP*G)-3'), NETROPSIN
Authors:Tabernero, L., Verdaguer, N., Coll, M., Fita, I., Van Der Marel, G.A., Van Boom, J.H., Rich, A., Aymami, J.
Deposit date:1993-04-14
Release date:1994-01-15
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Molecular structure of the A-tract DNA dodecamer d(CGCAAATTTGCG) complexed with the minor groove binding drug netropsin.
Biochemistry, 32, 1993
127D
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DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3') COMPLEXED WITH HOECHST 33258
Descriptor:DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), 2'-(4-HYDROXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE
Authors:Sriram, M., Van Der Marel, G.A., Roelen, H.L.P.F., Van Boom, J.H., Wang, A.H.-J.
Deposit date:1993-06-30
Release date:1994-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Conformation of B-DNA containing O6-ethyl-G-C base pairs stabilized by minor groove binding drugs: molecular structure of d(CGC[e6G]AATTCGCG complexed with Hoechst 33258 or Hoechst 33342.
EMBO J., 11, 1992
128D
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MOLECULAR STRUCTURE OF D(CGC[E6G]AATTCGCG) COMPLEXED WITH HOECHST 33258
Descriptor:DNA (5'-D(*CP*GP*CP*(G36)P*AP*AP*TP*TP*CP*GP*CP*G)-3'), 2'-(4-HYDROXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE
Authors:Sriram, M., Van Der Marel, G.A., Roelen, H.L.P.F., Van Boom, J.H., Wang, A.H.-J.
Deposit date:1993-06-30
Release date:1994-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Conformation of B-DNA containing O6-ethyl-G-C base pairs stabilized by minor groove binding drugs: molecular structure of d(CGC[e6G]AATTCGCG complexed with Hoechst 33258 or Hoechst 33342.
EMBO J., 11, 1992
129D
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DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3') COMPLEXED WITH HOECHST 33342
Descriptor:DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), 2'-(4-ETHOXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE
Authors:Sriram, M., Van Der Marel, G.A., Roelen, H.L.P.F., Van Boom, J.H., Wang, A.H.-J.
Deposit date:1993-06-30
Release date:1994-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Conformation of B-DNA containing O6-ethyl-G-C base pairs stabilized by minor groove binding drugs: molecular structure of d(CGC[e6G]AATTCGCG complexed with Hoechst 33258 or Hoechst 33342.
EMBO J., 11, 1992
130D
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MOLECULAR STRUCTURE OF D(CGC[E6G]AATTCGCG) COMPLEXED WITH HOECHST 33342
Descriptor:DNA (5'-D(*CP*GP*CP*(G36)P*AP*AP*TP*TP*CP*GP*CP*G)-3'), 2'-(4-ETHOXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE
Authors:Sriram, M., Van Der Marel, G.A., Roelen, H.L.P.F., Van Boom, J.H., Wang, A.H.-J.
Deposit date:1993-06-30
Release date:1994-01-15
Last modified:2011-08-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Conformation of B-DNA containing O6-ethyl-G-C base pairs stabilized by minor groove binding drugs: molecular structure of d(CGC[e6G]AATTCGCG complexed with Hoechst 33258 or Hoechst 33342.
EMBO J., 11, 1992
1D10
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STRUCTURAL COMPARISON OF ANTICANCER DRUG-DNA COMPLEXES. ADRIAMYCIN AND DAUNOMYCIN
Descriptor:DNA (5'-D(*CP*GP*AP*TP*CP*G)-3'), DAUNOMYCIN, SPERMINE, ...
Authors:Frederick, C.A., Williams, L.D., Ughetto, G., Van Der Marel, G.A., Van Boom, J.H., Rich, A., Wang, A.H.-J.
Deposit date:1989-10-20
Release date:1990-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural comparison of anticancer drug-DNA complexes: adriamycin and daunomycin.
Biochemistry, 29, 1990
1D12
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STRUCTURAL COMPARISON OF ANTICANCER DRUG-DNA COMPLEXES. ADRIAMYCIN AND DAUNOMYCIN
Descriptor:DNA (5'-D(*CP*GP*AP*TP*CP*G)-3'), DOXORUBICIN, SPERMINE, ...
Authors:Frederick, C.A., Williams, L.D., Ughetto, G., Van Der Marel, G.A., Van Boom, J.H., Rich, A., Wang, A.H.-J.
Deposit date:1989-10-20
Release date:1990-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural comparison of anticancer drug-DNA complexes: adriamycin and daunomycin.
Biochemistry, 29, 1990
1D13
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MOLECULAR STRUCTURE OF AN A-DNA DECAMER D(ACCGGCCGGT)
Descriptor:DNA (5'-D(*AP*CP*CP*GP*GP*CP*CP*GP*GP*T)-3')
Authors:Frederick, C.A., Quigley, G.J., Teng, M.-K., Coll, M., Van Der Marel, G.A., Van Boom, J.H., Rich, A., Wang, A.H.-J.
Deposit date:1989-10-20
Release date:1990-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular structure of an A-DNA decamer d(ACCGGCCGGT).
Eur.J.Biochem., 181, 1989
1D14
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STRUCTURE OF 11-DEOXYDAUNOMYCIN BOUND TO DNA CONTAINING A PHOSPHOROTHIOATE
Descriptor:DNA (5'-D(*CP*GP*TP*(AS)P*CP*G)-3'), 6-DEOXYDAUNOMYCIN
Authors:Williams, L.D., Egli, M., Ughetto, G., Van Der Marel, G.A., Van Boom, J.H., Quigley, G.J., Wang, A.H.-J., Rich, A., Frederick, C.A.
Deposit date:1989-10-20
Release date:1990-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of 11-deoxydaunomycin bound to DNA containing a phosphorothioate.
J.Mol.Biol., 215, 1990
1D35
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FACILE FORMATION OF A CROSSLINKED ADDUCT BETWEEN DNA AND THE DAUNORUBICIN DERIVATIVE MAR70 MEDIATED BY FORMALDEHYDE: MOLECULAR STRUCTURE OF THE MAR70-D(CGTNACG) COVALENT ADDUC
Descriptor:DNA (5'-D(*CP*GP*TP*(A40)P*CP*G)-3'), 4'-EPI-4'-(2-DEOXYFUCOSE)DAUNOMYCIN, MAGNESIUM ION
Authors:Gao, Y.-G., Liaw, Y.-C., Li, Y.-K., Van Der Marel, G.A., Van Boom, J.H., Wang, A.H.-J.
Deposit date:1991-04-23
Release date:1992-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Facile formation of a crosslinked adduct between DNA and the daunorubicin derivative MAR70 mediated by formaldehyde: molecular structure of the MAR70-d(CGTnACG) covalent adduct.
Proc.Natl.Acad.Sci.USA, 88, 1991
1D36
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FACILE FORMATION OF A CROSSLINKED ADDUCT BETWEEN DNA AND THE DAUNORUBICIN DERIVATIVE MAR70 MEDIATED BY FORMALDEHYDE: MOLECULAR STRUCTURE OF THE MAR70-D(CGTNACG) COVALENT ADDUC
Descriptor:DNA (5'-D(*CP*GP*TP*AP*CP*G)-3'), 4'-EPI-4'-(2-DEOXYFUCOSE)DAUNOMYCIN, MAGNESIUM ION
Authors:Gao, Y.-G., Liaw, Y.-C., Li, Y.-K., Van Der Marel, G.A., Van Boom, J.H., Wang, A.H.-J.
Deposit date:1991-04-23
Release date:1992-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Facile formation of a crosslinked adduct between DNA and the daunorubicin derivative MAR70 mediated by formaldehyde: molecular structure of the MAR70-d(CGTnACG) covalent adduct.
Proc.Natl.Acad.Sci.USA, 88, 1991
1D85
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STRUCTURAL CONSEQUENCES OF A CARCINOGENIC ALKYLATION LESION ON DNA: EFFECT OF O6-ETHYL-GUANINE ON THE MOLECULAR STRUCTURE OF D(CGC[E6G]AATTCGCG)-NETROPSIN COMPLEX
Descriptor:DNA (5'-D(*CP*GP*CP*(G36)P*AP*AP*TP*TP*CP*GP*CP*G)-3'), NETROPSIN
Authors:Sriram, M., Van Der Marel, G.A., Roelen, H.L.P.F., Van Boom, J.H., Wang, A.H.-J.
Deposit date:1992-08-24
Release date:1993-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural consequences of a carcinogenic alkylation lesion on DNA: effect of O6-ethylguanine on the molecular structure of the d(CGC[e6G]AATTCGCG)-netropsin complex.
Biochemistry, 31, 1992
1D86
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STRUCTURAL CONSEQUENCES OF A CARCINOGENIC ALKYLATION LESION ON DNA: EFFECT OF O6-ETHYL-GUANINE ON THE MOLECULAR STRUCTURE OF D(CGC[E6G]AATTCGCG)-NETROPSIN COMPLEX
Descriptor:DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), NETROPSIN
Authors:Sriram, M., Van Der Marel, G.A., Roelen, H.L.P.F., Van Boom, J.H., Wang, A.H.-J.
Deposit date:1992-08-24
Release date:1993-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural consequences of a carcinogenic alkylation lesion on DNA: effect of O6-ethylguanine on the molecular structure of the d(CGC[e6G]AATTCGCG)-netropsin complex.
Biochemistry, 31, 1992