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6DMG
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BU of 6dmg by Molmil
A multiconformer ligand model of EK6 bound to ERK2
Descriptor: 1,2-ETHANEDIOL, Mitogen-activated protein kinase 1, SULFATE ION, ...
Authors:Hudson, B.M, van Zundert, G.C.P, Keedy, D.A, Fonseca, R, Heliou, A, Suresh, P, Borrelli, K, Day, T, Fraser, J.S, van den Bedem, H.
Deposit date:2018-06-05
Release date:2018-12-19
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:qFit-ligand Reveals Widespread Conformational Heterogeneity of Drug-Like Molecules in X-Ray Electron Density Maps.
J. Med. Chem., 61, 2018
6DMH
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BU of 6dmh by Molmil
A multiconformer ligand model of acylenzyme intermediate of meropenem bound to an SFC-1 E166A mutant
Descriptor: (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, 1,2-ETHANEDIOL, Beta-lactamase
Authors:Hudson, B.M, van Zundert, G, Keedy, D, Fonseca, R, Heliou, A, Suresh, P, Borrelli, K, Day, T, Fraser, J.S, van den Bedem, H.
Deposit date:2018-06-05
Release date:2018-12-19
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:qFit-ligand Reveals Widespread Conformational Heterogeneity of Drug-Like Molecules in X-Ray Electron Density Maps.
J. Med. Chem., 61, 2018
6DML
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BU of 6dml by Molmil
A multiconformer ligand model of 3,5 dimethylisoxaxole bound to the bromodomain of human BRD4
Descriptor: 1,2-ETHANEDIOL, 4-((2-(tert-butyl)phenyl)amino)-7-(3,5-dimethylisoxazol-4-yl)-6-methoxy-1,5-naphthyridine-3-carboxylic acid, Bromodomain-containing protein 4
Authors:Hudson, B.M, van Zundert, G, Keedy, D, Fonseca, R, Heliou, A, Suresh, P, Borrelli, K, Day, T, Fraser, J.S, van den Bedem, H.
Deposit date:2018-06-05
Release date:2018-12-19
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:qFit-ligand Reveals Widespread Conformational Heterogeneity of Drug-Like Molecules in X-Ray Electron Density Maps.
J. Med. Chem., 61, 2018
6DMJ
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BU of 6dmj by Molmil
A multiconformer ligand model of inhibitor 53W bound to CREB binding protein bromodomain
Descriptor: 5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[2-(4-methoxyphenyl)ethyl]-1-[2-(morpholin-4-yl)ethyl]-1H-benzimidazole, Bromodomain-containing protein 4
Authors:Hudson, B.M, van Zundert, G, Keedy, D, Fonseca, R, Heliou, A, Suresh, P, Borrelli, K, Day, T, Fraser, J.S, van den Bedem, H.
Deposit date:2018-06-05
Release date:2018-12-19
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:qFit-ligand Reveals Widespread Conformational Heterogeneity of Drug-Like Molecules in X-Ray Electron Density Maps.
J. Med. Chem., 61, 2018
6DMI
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BU of 6dmi by Molmil
A multiconformer ligand model of 5T5 bound to BACE-1
Descriptor: Beta-secretase 1, DIMETHYL SULFOXIDE, SODIUM ION, ...
Authors:Hudson, B.M, van Zundert, G, Keedy, D, Fonseca, R, Heliou, A, Suresh, P, Borrelli, K, Day, T, Fraser, J.S, van den Bedem, H.
Deposit date:2018-06-05
Release date:2018-12-19
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:qFit-ligand Reveals Widespread Conformational Heterogeneity of Drug-Like Molecules in X-Ray Electron Density Maps.
J. Med. Chem., 61, 2018
6DMK
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BU of 6dmk by Molmil
A multiconformer ligand model of an isoxazolyl-benzimidazole ligand bound to the bromodomain of human CREBBP
Descriptor: 1,2-ETHANEDIOL, 5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[2-(morpholin-4-yl)ethyl]-2-(2-phenylethyl)-1H-benzimidazole, CREB-binding protein, ...
Authors:Hudson, B.M, van Zundert, G, Keedy, D, Fonseca, R, Heliou, A, Suresh, P, Borrelli, K, Day, T, Fraser, J.S, van den Bedem, H.
Deposit date:2018-06-05
Release date:2018-12-19
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:qFit-ligand Reveals Widespread Conformational Heterogeneity of Drug-Like Molecules in X-Ray Electron Density Maps.
J. Med. Chem., 61, 2018
7VFX
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BU of 7vfx by Molmil
The structure of Formyl Peptide Receptor 1 in complex with Gi and peptide agonist fMIFL
Descriptor: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Wang, X.K, Chen, G, Liao, Q.W, Du, Y, Hu, H.L, Ye, D.Q.
Deposit date:2021-09-14
Release date:2022-09-21
Last modified:2022-12-07
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns.
Nat Commun, 13, 2022
7EUO
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BU of 7euo by Molmil
The structure of formyl peptide receptor 1 in complex with Gi and peptide agonist fMLF
Descriptor: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Wang, X.K, Chen, G, Liao, Q.W, Du, Y, Hu, H.L, Ye, D.Q.
Deposit date:2021-05-18
Release date:2022-05-25
Last modified:2022-12-07
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns.
Nat Commun, 13, 2022
7MIH
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BU of 7mih by Molmil
Human CTPS2 bound to inhibitor R80
Descriptor: CTP synthase 2, GLUTAMINE, MAGNESIUM ION, ...
Authors:Lynch, E.M, Dimattia, M.A, Kollman, J.M.
Deposit date:2021-04-16
Release date:2021-10-13
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis for isoform-specific inhibition of human CTPS1.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MIG
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BU of 7mig by Molmil
Human CTPS1 bound to inhibitor T35
Descriptor: 2-{2-[(cyclopropanesulfonyl)amino]-1,3-thiazol-4-yl}-2-methyl-N-{5-[6-(trifluoromethyl)pyrazin-2-yl]pyridin-2-yl}propanamide, CTP synthase 1, GLUTAMINE, ...
Authors:Lynch, E.M, Dimattia, M.A, Kollman, J.M.
Deposit date:2021-04-16
Release date:2021-10-13
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis for isoform-specific inhibition of human CTPS1.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MH0
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BU of 7mh0 by Molmil
Human CTPS1 bound to CTP
Descriptor: CTP synthase 1, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Lynch, E.M, Kollman, J.M.
Deposit date:2021-04-14
Release date:2021-10-13
Method:ELECTRON MICROSCOPY (6.2 Å)
Cite:Structural basis for isoform-specific inhibition of human CTPS1.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MIV
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BU of 7miv by Molmil
Mouse CTPS2-I250T bound to inhibitor R80
Descriptor: CTP synthase 2, GLUTAMINE, MAGNESIUM ION, ...
Authors:Lynch, E.M, Dimattia, M.A, Kollman, J.M.
Deposit date:2021-04-17
Release date:2021-10-13
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis for isoform-specific inhibition of human CTPS1.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MII
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BU of 7mii by Molmil
Human CTPS2 bound to inhibitor T35
Descriptor: 2-{2-[(cyclopropanesulfonyl)amino]-1,3-thiazol-4-yl}-2-methyl-N-{5-[6-(trifluoromethyl)pyrazin-2-yl]pyridin-2-yl}propanamide, CTP synthase 2, GLUTAMINE, ...
Authors:Lynch, E.M, Dimattia, M.A, Kollman, J.M.
Deposit date:2021-04-16
Release date:2021-10-13
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural basis for isoform-specific inhibition of human CTPS1.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MH1
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BU of 7mh1 by Molmil
Human CTPS2 bound to CTP
Descriptor: CTP synthase 2, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Lynch, E.M, Kollman, J.M.
Deposit date:2021-04-14
Release date:2021-10-13
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis for isoform-specific inhibition of human CTPS1.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MIU
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BU of 7miu by Molmil
Mouse CTPS2 bound to inhibitor R80
Descriptor: CTP synthase 2, GLUTAMINE, MAGNESIUM ION, ...
Authors:Lynch, E.M, Dimattia, M.A, Kollman, J.M.
Deposit date:2021-04-17
Release date:2021-10-13
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural basis for isoform-specific inhibition of human CTPS1.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MIP
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BU of 7mip by Molmil
Mouse CTPS1 bound to inhibitor R80
Descriptor: CTP synthase 1, GLUTAMINE, MAGNESIUM ION, ...
Authors:Lynch, E.M, Dimattia, M.A, Kollman, J.M.
Deposit date:2021-04-17
Release date:2021-10-13
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Structural basis for isoform-specific inhibition of human CTPS1.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MGZ
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BU of 7mgz by Molmil
Human CTPS1 bound to UTP, AMPPNP, and glutamine
Descriptor: CTP synthase 1, GLUTAMINE, MAGNESIUM ION, ...
Authors:Lynch, E.M, Dimattia, M.A, Kollman, J.M.
Deposit date:2021-04-14
Release date:2021-10-13
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis for isoform-specific inhibition of human CTPS1.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MIF
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BU of 7mif by Molmil
Human CTPS1 bound to inhibitor R80
Descriptor: CTP synthase 1, GLUTAMINE, MAGNESIUM ION, ...
Authors:Lynch, E.M, Dimattia, M.A, Kollman, J.M.
Deposit date:2021-04-16
Release date:2021-10-13
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for isoform-specific inhibition of human CTPS1.
Proc.Natl.Acad.Sci.USA, 118, 2021

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PDB entries from 2024-03-27

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