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4V3P
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BU of 4v3p by Molmil
The molecular structure of the left-handed supra-molecular helix of eukaryotic polyribosomes
Descriptor: 18S ribosomal RNA, 26S ribosomal RNA, 40S WHEAT GERM RIBOSOME protein 4, ...
Authors:Myasnikov, A.G, Afonina, Z.A, Menetret, J.F, Shirokov, V.A, Spirin, A.S, Klaholz, B.P.
Deposit date:2014-10-20
Release date:2015-04-22
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (34 Å)
Cite:The molecular structure of the left-handed supra-molecular helix of eukaryotic polyribosomes.
Nat Commun, 5, 2014
5LKS
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BU of 5lks by Molmil
Structure-function insights reveal the human ribosome as a cancer target for antibiotics
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ...
Authors:Myasnikov, A.G, Natchiar, S.K, Nebout, M, Hazemann, I, Imbert, V, Khatter, H, Peyron, J.-F, Klaholz, B.P.
Deposit date:2016-07-23
Release date:2017-04-26
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure-function insights reveal the human ribosome as a cancer target for antibiotics.
Nat Commun, 7, 2016
5OEJ
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BU of 5oej by Molmil
Structure of Tra1 subunit within the chromatin modifying complex SAGA
Descriptor: Tra1 subunit within the chromatin modifying complex SAGA
Authors:Sharov, G, Voltz, K, Durand, A, Kolesnikova, O, Papai, G, Myasnikov, A.G, Dejaegere, A, Ben-Shem, A, Schultz, P.
Deposit date:2017-07-07
Release date:2017-08-02
Last modified:2017-11-29
Method:ELECTRON MICROSCOPY (5.7 Å)
Cite:Structure of the transcription activator target Tra1 within the chromatin modifying complex SAGA.
Nat Commun, 8, 2017
8GLP
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BU of 8glp by Molmil
mRNA decoding in human is kinetically and structurally distinct from bacteria (Consensus LSU focused refined structure)
Descriptor: 1,4-DIAMINOBUTANE, 18S rRNA, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Watson, Z.L, Altman, R.B, Blanchard, S.C.
Deposit date:2023-03-22
Release date:2023-04-19
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (1.67 Å)
Cite:mRNA decoding in human is kinetically and structurally distinct from bacteria.
Nature, 617, 2023
2VAZ
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BU of 2vaz by Molmil
Model of the S15-mRNA complex fitted into the cryo-EM map of the 70S entrapment complex.
Descriptor: 30S RIBOSOMAL PROTEIN S15, RPSO MRNA OPERATOR
Authors:Marzi, S, Myasnikov, A.G, Serganov, A, Ehresmann, C, Romby, P, Yusupov, M, Klaholz, B.P.
Deposit date:2007-09-05
Release date:2007-10-02
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (10 Å)
Cite:Structured Mrnas Regulate Translation Initiation by Binding to the Platform of the Ribosome.
Cell(Cambridge,Mass.), 130, 2007
1ML5
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BU of 1ml5 by Molmil
Structure of the E. coli ribosomal termination complex with release factor 2
Descriptor: 30S 16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, 30S RIBOSOMAL PROTEIN S11, ...
Authors:Klaholz, B.P, Pape, T, Zavialov, A.V, Myasnikov, A.G, Orlova, E.V, Vestergaard, B, Ehrenberg, M, van Heel, M.
Deposit date:2002-08-30
Release date:2003-01-14
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (14 Å)
Cite:Structure of the Escherichia coli ribosomal termination complex with release factor 2
Nature, 421, 2003
5K1H
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BU of 5k1h by Molmil
eIF3b relocated to the intersubunit face to interact with eIF1 and below the eIF2 ternary-complex. from the structure of a partial yeast 48S preinitiation complex in closed conformation.
Descriptor: Eukaryotic translation initiation factor 3 subunit B, eIF3a C-terminal tail
Authors:Simonetti, A, Brito Querido, J, Myasnikov, A.G, Mancera-Martinez, E, Renaud, A, Kuhn, L, Hashem, Y.
Deposit date:2016-05-18
Release date:2016-07-13
Last modified:2018-01-31
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon Recognition.
Mol.Cell, 63, 2016
5K0Y
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BU of 5k0y by Molmil
m48S late-stage initiation complex, purified from rabbit reticulocytes lysates, displaying eIF2 ternary complex and eIF3 i and g subunits relocated to the intersubunit face
Descriptor: 18S ribosomal RNA, 40S ribosomal protein S12, 40S ribosomal protein S21, ...
Authors:Simonetti, A, Brito Querido, J, Myasnikov, A.G, Mancera-Martinez, E, Renaud, A, Kuhn, L, Hashem, Y.
Deposit date:2016-05-17
Release date:2016-07-13
Last modified:2018-04-18
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon Recognition.
Mol.Cell, 63, 2016
6BQR
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BU of 6bqr by Molmil
Human TRPM4 ion channel in lipid nanodiscs in a calcium-free state
Descriptor: CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 4
Authors:Autzen, H.E, Myasnikov, A.G, Campbell, M.G, Asarnow, D, Julius, D, Cheng, Y.
Deposit date:2017-11-28
Release date:2017-12-20
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of the human TRPM4 ion channel in a lipid nanodisc.
Science, 359, 2018
6BQV
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BU of 6bqv by Molmil
Human TRPM4 ion channel in lipid nanodiscs in a calcium-bound state
Descriptor: CALCIUM ION, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 4
Authors:Autzen, H.E, Myasnikov, A.G, Campbell, M.G, Asarnow, D, Julius, D, Cheng, Y.
Deposit date:2017-11-28
Release date:2017-12-20
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structure of the human TRPM4 ion channel in a lipid nanodisc.
Science, 359, 2018
6XZA
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BU of 6xza by Molmil
E. coli 70S ribosome in complex with dirithromycin, and deacylated tRNA(iMet) (focused classification).
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
Authors:Pichkur, E.B, Polikanov, Y.S, Myasnikov, A.G, Konevega, A.L.
Deposit date:2020-02-03
Release date:2020-11-04
Method:ELECTRON MICROSCOPY (2.66 Å)
Cite:Insights into the improved macrolide inhibitory activity from the high-resolution cryo-EM structure of dirithromycin bound to the E. coli 70S ribosome.
Rna, 26, 2020
6XZB
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BU of 6xzb by Molmil
E. coli 70S ribosome in complex with dirithromycin, fMet-Phe-tRNA(Phe) and deacylated tRNA(iMet) (focused classification).
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
Authors:Pichkur, E.B, Polikanov, Y.S, Myasnikov, A.G, Konevega, A.L.
Deposit date:2020-02-03
Release date:2020-11-04
Method:ELECTRON MICROSCOPY (2.54 Å)
Cite:Insights into the improved macrolide inhibitory activity from the high-resolution cryo-EM structure of dirithromycin bound to the E. coli 70S ribosome.
Rna, 26, 2020
6XZ7
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BU of 6xz7 by Molmil
E. coli 50S ribosomal subunit in complex with dirithromycin, fMet-Phe-tRNA(Phe) and deacylated tRNA(iMet).
Descriptor: 23S rRNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ...
Authors:Pichkur, E.B, Polikanov, Y.S, Myasnikov, A.G, Konevega, A.L.
Deposit date:2020-02-03
Release date:2020-07-22
Method:ELECTRON MICROSCOPY (2.1 Å)
Cite:Insights into the improved macrolide inhibitory activity from the high-resolution cryo-EM structure of dirithromycin bound to theE. coli70S ribosome.
Rna, 26, 2020
8G60
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BU of 8g60 by Molmil
mRNA decoding in human is kinetically and structurally distinct from bacteria (CR state)
Descriptor: 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ...
Authors:Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C.
Deposit date:2023-02-14
Release date:2023-04-19
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.54 Å)
Cite:mRNA decoding in human is kinetically and structurally distinct from bacteria.
Nature, 617, 2023
8G5Z
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BU of 8g5z by Molmil
mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state)
Descriptor: 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ...
Authors:Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C.
Deposit date:2023-02-14
Release date:2023-04-19
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.64 Å)
Cite:mRNA decoding in human is kinetically and structurally distinct from bacteria.
Nature, 617, 2023
8G5Y
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BU of 8g5y by Molmil
mRNA decoding in human is kinetically and structurally distinct from bacteria (IC state)
Descriptor: 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ...
Authors:Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C.
Deposit date:2023-02-14
Release date:2023-04-19
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.29 Å)
Cite:mRNA decoding in human is kinetically and structurally distinct from bacteria.
Nature, 617, 2023
8G6J
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BU of 8g6j by Molmil
mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state 2)
Descriptor: (3R,6R,9S,12S,15S,18S,20R,24aR)-6-[(2S)-butan-2-yl]-3,12-bis[(1R)-1-hydroxy-2-methylpropyl]-8,9,11,17,18-pentamethyl-15-[(2S)-2-methylbutyl]hexadecahydropyrido[1,2-a][1,4,7,10,13,16,19]heptaazacyclohenicosine-1,4,7,10,13,16,19(21H)-heptone, (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 1,4-DIAMINOBUTANE, ...
Authors:Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C.
Deposit date:2023-02-15
Release date:2023-04-19
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:mRNA decoding in human is kinetically and structurally distinct from bacteria.
Nature, 617, 2023
8G61
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BU of 8g61 by Molmil
mRNA decoding in human is kinetically and structurally distinct from bacteria (AC state)
Descriptor: 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ...
Authors:Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C.
Deposit date:2023-02-14
Release date:2023-04-19
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.94 Å)
Cite:mRNA decoding in human is kinetically and structurally distinct from bacteria.
Nature, 617, 2023
6QZP
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BU of 6qzp by Molmil
High-resolution cryo-EM structure of the human 80S ribosome
Descriptor: (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 18S rRNA (1740-MER), 28S rRNA (3773-MER), ...
Authors:Natchiar, S.K, Myasnikov, A.G, Kratzat, H, Hazemann, I, Klaholz, B.P.
Deposit date:2019-03-12
Release date:2019-04-24
Last modified:2021-08-04
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Visualization of chemical modifications in the human 80S ribosome structure.
Nature, 551, 2017
6XLF
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BU of 6xlf by Molmil
Full-length Hsc82 in complex with Aha1 in the presence of AMP-PNP
Descriptor: ATP-dependent molecular chaperone HSC82, Hsp90 co-chaperone AHA1, MAGNESIUM ION, ...
Authors:Liu, Y.X, Sun, M, Myasnikov, A.G, Elnatan, D, Agard, D.A.
Deposit date:2020-06-28
Release date:2021-06-30
Method:ELECTRON MICROSCOPY (3.15 Å)
Cite:Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1
To Be Published
6XLC
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BU of 6xlc by Molmil
Full-length Hsc82 bound to AMPPNP
Descriptor: ATP-dependent molecular chaperone HSC82, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Liu, Y.X, Sun, M, Myasnikov, A.G, Elnatan, D, Agard, D.A.
Deposit date:2020-06-28
Release date:2021-06-30
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.66 Å)
Cite:Full-length Hsc82 bound to AMPPNP
To Be Published
6XLB
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BU of 6xlb by Molmil
Apo full-length Hsc82 in complex with Aha1
Descriptor: ATP-dependent molecular chaperone HSC82, Hsp90 co-chaperone AHA1
Authors:Liu, Y.X, Sun, M, Myasnikov, A.G, Elnatan, D, Agard, D.A.
Deposit date:2020-06-28
Release date:2021-06-30
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Apo full-length Hsc82 in complex with Aha1
To Be Published
6XLG
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BU of 6xlg by Molmil
Full-length Hsc82 in complex with two Aha1 CTD in the presence of ATPgammaS
Descriptor: ATP-dependent molecular chaperone HSC82, Hsp90 co-chaperone AHA1, MAGNESIUM ION, ...
Authors:Liu, Y.X, Sun, M, Myasnikov, A.G, Elnatan, D, Agard, D.A.
Deposit date:2020-06-28
Release date:2021-06-30
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (2.71 Å)
Cite:Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1
To Be Published
6XLE
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BU of 6xle by Molmil
Full-length Hsc82 in complex with two Aha1 CTD in the presence of AMP-PNP
Descriptor: ATP-dependent molecular chaperone HSC82, Hsp90 co-chaperone AHA1, MAGNESIUM ION, ...
Authors:Liu, Y.X, Sun, M, Myasnikov, A.G, Elnatan, D, Agard, D.A.
Deposit date:2020-06-28
Release date:2021-06-30
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (2.74 Å)
Cite:Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1
To Be Published
6XLH
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BU of 6xlh by Molmil
Asymmetric hydrolysis state of Hsc82 in complex with Aha1 bound with ADP and ATPgammaS
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent molecular chaperone HSC82, Hsp90 co-chaperone AHA1, ...
Authors:Liu, Y.X, Sun, M, Myasnikov, A.G, Elnatan, D, Agard, D.A.
Deposit date:2020-06-28
Release date:2021-06-30
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1
To Be Published

 

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