Author results

4RED
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CRYSTAL STRUCTURE OF HUMAN AMPK ALPHA1 KD-AID WITH K43A MUTATION
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1
Authors:Zhou, X.E., Ke, J., Li, X., Wang, L., Gu, X., de Waal, P.W., Tan, M.H.E., Wang, D., Wu, D., Xu, H.E., Melcher, K.
Deposit date:2014-09-22
Release date:2014-12-10
Last modified:2015-03-11
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural basis of AMPK regulation by adenine nucleotides and glycogen.
Cell Res., 25, 2015
4RER
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CRYSTAL STRUCTURE OF THE PHOSPHORYLATED HUMAN ALPHA1 BETA2 GAMMA1 HOLO-AMPK COMPLEX BOUND TO AMP AND CYCLODEXTRIN
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Zhou, X.E., Ke, J., Li, X., Wang, L., Gu, X., de Waal, P.W., Tan, M.H.E., Wang, D., Wu, D., Xu, H.E., Melcher, K.
Deposit date:2014-09-23
Release date:2014-12-10
Last modified:2015-03-11
Method:X-RAY DIFFRACTION (4.047 Å)
Cite:Structural basis of AMPK regulation by adenine nucleotides and glycogen.
Cell Res., 25, 2015
4REW
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CRYSTAL STRUCTURE OF THE NON-PHOSPHORYLATED HUMAN ALPHA1 BETA2 GAMMA1 HOLO-AMPK COMPLEX
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Zhou, X.E., Ke, J., Li, X., Wang, L., Gu, X., de Waal, P.W., Tan, M.H.E., Wang, D., Wu, D., Xu, H.E., Melcher, K.
Deposit date:2014-09-24
Release date:2014-12-10
Last modified:2015-03-11
Method:X-RAY DIFFRACTION (4.58 Å)
Cite:Structural basis of AMPK regulation by adenine nucleotides and glycogen.
Cell Res., 25, 2015
4ZWJ
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CRYSTAL STRUCTURE OF RHODOPSIN BOUND TO ARRESTIN BY FEMTOSECOND X-RAY LASER
Descriptor:Chimera protein of human Rhodopsin, mouse S-arrestin, and T4 Endolysin
Authors:Kang, Y., Zhou, X.E., Gao, X., He, Y., Liu, W., Ishchenko, A., Barty, A., White, T.A., Yefanov, O., Han, G.W., Xu, Q., de Waal, P.W., Ke, J., Tan, M.H.E., Zhang, C., Moeller, A., West, G.M., Pascal, B., Eps, N.V., Caro, L.N., Vishnivetskiy, S.A., Lee, R.J., Suino-Powell, K.M., Gu, X., Pal, K., Ma, J., Zhi, X., Boutet, S., Williams, G.J., Messerschmidt, M., Gati, C., Zatsepin, N.A., Wang, D., James, D., Basu, S., Roy-Chowdhury, S., Conrad, C., Coe, J., Liu, H., Lisova, S., Kupitz, C., Grotjohann, I., Fromme, R., Jiang, Y., Tan, M., Yang, H., Li, J., Wang, M., Zheng, Z., Li, D., Howe, N., Zhao, Y., Standfuss, J., Diederichs, K., Dong, Y., Potter, C.S., Carragher, B., Caffrey, M., Jiang, H., Chapman, H.N., Spence, J.C.H., Fromme, P., Weierstall, U., Ernst, O.P., Katritch, V., Gurevich, V.V., Griffin, P.R., Hubbell, W.L., Stevens, R.C., Cherezov, V., Melcher, K., Xu, H.E., GPCR Network (GPCR)
Deposit date:2015-05-19
Release date:2015-07-29
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (3.302 Å)
Cite:Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser.
Nature, 523, 2015
5DGY
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CRYSTAL STRUCTURE OF RHODOPSIN BOUND TO VISUAL ARRESTIN
Descriptor:Endolysin,Rhodopsin,S-arrestin
Authors:Zhou, X.E., Gao, X., Kang, Y., He, Y., de Waal, P.W., Suino-Powell, K.M., Wang, M., Melcher, K., Xu, H.E.
Deposit date:2015-08-28
Release date:2016-03-23
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (7.7 Å)
Cite:X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex.
Sci Data, 3, 2016
5DJ5
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CRYSTAL STRUCTURE OF RICE DWARF14 IN COMPLEX WITH SYNTHETIC STRIGOLACTONE GR24
Descriptor:Probable strigolactone esterase D14, (3E,3aR,8bS)-3-({[(2R)-4-methyl-5-oxo-2,5-dihydrofuran-2-yl]oxy}methylidene)-3,3a,4,8b-tetrahydro-2H-indeno[1,2-b]furan-2-one
Authors:Zhou, X.E., Zhao, L.-H., Yi, W., Wu, Z.-S., Liu, Y., Kang, Y., Hou, L., de Waal, P.W., Li, S., Jiang, Y., Melcher, K., Xu, H.E.
Deposit date:2015-09-01
Release date:2015-10-28
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3.
Cell Res., 25, 2015
5TDH
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THE CRYSTAL STRUCTURE OF THE DOMINANT NEGATIVE MUTANT G PROTEIN ALPHA(I)-1-BETA-1-GAMMA-2 G203A/A326S
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Liu, P., Jia, M.-Z., Zhou, X.E., de Waal, P.W., Dickson, B.M., Liu, B., Hou, L., Yin, Y.-T., Kang, Y.-Y., Shi, Y., Melcher, K., Xu, H.E., Jiang, Y.
Deposit date:2016-09-19
Release date:2016-11-09
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structural basis of the dominant negative phenotype of the G alpha i1 beta 1 gamma 2 G203A/A326S heterotrimer
Acta Pharmacol.Sin., 37, 2016
5W0P
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CRYSTAL STRUCTURE OF RHODOPSIN BOUND TO VISUAL ARRESTIN DETERMINED BY X-RAY FREE ELECTRON LASER
Descriptor:Endolysin,Rhodopsin,S-arrestin, N-ACETYL-D-GLUCOSAMINE
Authors:Zhou, X.E., He, Y., de Waal, P.W., Gao, X., Kang, Y., Van Eps, N., Yin, Y., Pal, K., Goswami, D., White, T.A., Barty, A., Latorraca, N.R., Chapman, H.N., Hubbell, W.L., Dror, R.O., Stevens, R.C., Cherezov, V., Gurevich, V.V., Griffin, P.R., Ernst, O.P., Melcher, K., Xu, H.E.
Deposit date:2017-05-31
Release date:2017-08-09
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (3.013 Å)
Cite:Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors.
Cell, 170, 2017
6CMO
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RHODOPSIN-GI COMPLEX
Descriptor:chimera protein of Soluble cytochrome b562 and Rhodopsin, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Kang, Y., Kuybeda, O., de Waal, P.W., Mukherjee, S., Van Eps, N., Dutka, P., Zhou, X.E., Bartesaghi, A., Erramilli, S., Morizumi, T., Gu, X., Yin, Y., Liu, P., Jiang, Y., Meng, X., Zhao, G., Melcher, K., Earnst, O.P., Kossiakoff, A.A., Subramaniam, S., Xu, H.E.
Deposit date:2018-03-05
Release date:2018-06-20
Last modified:2019-04-17
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.
Nature, 558, 2018
5J9F
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HUMAN GAR TRANSFORMYLASE IN COMPLEX WITH GAR AND (4-{[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)ETHYL]AMINO}BENZOYL)-L-GLUTAMIC ACID (AGF183)
Descriptor:Trifunctional purine biosynthetic protein adenosine-3, GLYCINAMIDE RIBONUCLEOTIDE, N-(4-{[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)ethyl]amino}benzene-1-carbonyl)-L-glutamic acid
Authors:Wong, J., Deis, S.M., Dann III, C.E.
Deposit date:2016-04-09
Release date:2016-08-10
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor alpha and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.
J.Med.Chem., 59, 2016
5IZQ
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CRYSTAL STRUCTURE OF HUMAN FOLATE RECEPTOR ALPHA IN COMPLEX WITH NOVEL ANTIFOLATE AGF183
Descriptor:Folate receptor alpha, N-(4-{[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)ethyl]amino}benzene-1-carbonyl)-L-glutamic acid
Authors:Ke, J., Gu, X., Brunzelle, J.S., Xu, H.E., Melcher, K.
Deposit date:2016-03-25
Release date:2016-08-10
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor alpha and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.
J.Med.Chem., 59, 2016
6BD4
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CRYSTAL STRUCTURE OF HUMAN APO-FRIZZLED4 RECEPTOR
Descriptor:Frizzled-4/Rubredoxin chimeric protein, ZINC ION, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
Authors:Yang, S., Wu, Y., Pu, M., Chen, Y., Dong, S., Guo, Y., Han, G.Y., Stevens, R.C., Zhao, S., Xu, F.
Deposit date:2017-10-21
Release date:2018-08-22
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the Frizzled 4 receptor in a ligand-free state.
Nature, 560, 2018